benzoic acid pirrolidin-3-yl ester | 51285-23-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzoic acid pirrolidin-3-yl ester
• 英文别名: benzoic acid pyrrolidin-3yl ester；pyrrolidin-3-yl benzoate
• CAS: 51285-23-5
• 化学式: C₁₁H₁₃NO₂
• 分子量: 191.23
• InChiKey: RSCLTAHCZHPGHS-UHFFFAOYSA-N

物化性质

• 沸点：
  294.9±33.0 °C(Predicted)
• 密度：
  1.15±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Boc-D-苯丙氨酸 、 benzoic acid pirrolidin-3-yl ester 在 TEA 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 作用下， 以 二氯甲烷 为溶剂， 以84%的产率得到
  参考文献：
  名称：

  Syntheses of new modified Phe-Pro peptides. Use of proline replacements in potential HIV inhibitors

  摘要：

  The syntheses consisting of replacement of proline amino acid by a 3-pyrrolidinone ring in Phe-Pro analogues are described. Preliminary anti-HIV studies demonstrated the potential activity of this new class of compounds. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00006-7
• 作为产物：
  描述：

  tert-butyl 3-(benzoyloxy)pyrrolidine-1-carboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以100%的产率得到benzoic acid pirrolidin-3-yl ester
  参考文献：
  名称：

  Syntheses of new modified Phe-Pro peptides. Use of proline replacements in potential HIV inhibitors

  摘要：

  The syntheses consisting of replacement of proline amino acid by a 3-pyrrolidinone ring in Phe-Pro analogues are described. Preliminary anti-HIV studies demonstrated the potential activity of this new class of compounds. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00006-7

文献信息

• ORGANIC COMPOUNDS
  申请人：Mogi Muneto

  公开号：US20090118287A1

  公开（公告）日：2009-05-07

  The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.

  本发明提供了一种化合物，其化学式为（I）：其中变体R1、R2、R3、R4、R5、R6、R7如本文所定义，并且所述化合物是CETP的抑制剂，因此可用于治疗由CETP介导或对CETP抑制响应的疾病或疾病。
• The use of borane–amine adducts as versatile palladium-catalyzed hydrogen-transfer reagents in methanol
  作者：Michel Couturier、Brian M Andresen、John L Tucker、Pascal Dubé、Steven J Brenek、Joanna T Negri

  DOI：10.1016/s0040-4039(01)00300-8

  日期：2001.4

  reducing agents is broadened through palladium-catalyzed methanolysis capable of reducing a wide variety of functional groups. Hence, borane mediated reduction of a benzamide followed by a tandem methanolysis/hydrogenolysis of the resulting borane–benzylamine adduct allows chemoselective removal of an N-benzoyl in the presence of an O-benzoyl.

  硼烷-胺加合物作为还原剂的范围通过钯催化的甲醇分解反应得以扩大，该反应能够还原多种官能团。因此，硼烷介导的苯甲酰胺还原，然后串联甲醇分解/氢解所得的硼烷-苄胺加合物，可以在O-苯甲酰基存在下化学选择性除去N-苯甲酰基。
• [EN] PROCESS FOR THE PREPARATION OF PYRROLIDINYL ETHYLAMINE COMPOUNDS VIA A COPPER-MEDIATED ARYL AMINATION<br/>[FR] PROCEDE SERVANT A PREPARER DES COMPOSES DE PYROLIDINYLE ETHYLAMINE PAR L'INTERMEDIAIRE D'UNE ARYLAMINATION PROVOQUEE PAR DU CUIVRE
  申请人：PFIZER PROD INC

  公开号：WO2004039785A1

  公开（公告）日：2004-05-13

  The invention provides a new process for the preparation of compounds of formula (XI) which are useful as kappa agonists. The process involves, as a key step, a copper-mediated aryl amination.

  这项发明提供了一种新的制备公式（XI）化合物的方法，这些化合物作为kappa受体激动剂具有用途。该方法的关键步骤是铜介导的芳基胺化反应。
• Aminocyclohexyl ether compounds and uses thereof
  申请人：Barrett G.M.

  公开号：US20070099983A1

  公开（公告）日：2007-05-03

  Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.

  本发明公开了氨基环己醚化合物。本发明的化合物可纳入组合物和套件中。本发明还公开了化合物和组合物的用途，包括治疗心律失常。
• Process for pyrrolidinyl hydroxamic acid compounds
  申请人：Pfizer Inc.

  公开号：US06031114A1

  公开（公告）日：2000-02-29

  A method for preparing hydroxamic acid derivatives which are useful as analgesic, antiinflammatory, or neuroprotective agents.

  一种制备羟肟酸衍生物的方法，其可用作镇痛剂、抗炎剂或神经保护剂。