(Z)-C-(1-pyrenyl)-N-benzyl nitrone | 835628-04-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: (Z)-C-(1-pyrenyl)-N-benzyl nitrone
• 英文别名: N-benzyl-1-pyren-1-ylmethanimine oxide
• CAS: 835628-04-1；875119-97-4
• 化学式: C₂₄H₁₇NO
• 分子量: 335.405
• InChiKey: YWGSUSQCNUZVQM-XYGWBWBKSA-N

物化性质

• 沸点：
  582.0±43.0 °C(Predicted)
• 密度：
  1.277±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  28.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (Z)-C-(1-pyrenyl)-N-benzyl nitrone 、 丙烯基-1,3-磺酸内酯 在 叔丁基对羟基茴香醚 作用下， 以 甲苯 为溶剂， 反应 48.0h， 以72%的产率得到
  参考文献：
  名称：

  A Ratiometric Fluorescent Sensor for Ag^I with High Selectivity and Sensitivity

  摘要：

  A bicyclic cycloadduct 1 bearing a pyrenyl moiety has been synthesized and investigated as a ratiometric fluorescent sensor for AgI. In an aqueous ethanol solution of 1, the presence of silver ion induces the formation of a 1:2 metal-ligand complex, which exhibits a strong intensity enhancement of the pyrene excimer emission at the expense of the emission of monomeric pyrene.

  DOI：

  10.1021/ja029253d
• 作为产物：
  描述：

  苯甲醛肟 在 盐酸 、 sodium cyanoborohydride 作用下， 以 甲醇 、 苯 为溶剂， 反应 6.0h， 生成 (Z)-C-(1-pyrenyl)-N-benzyl nitrone
  参考文献：
  名称：

  A Ratiometric Fluorescent Sensor for Ag^I with High Selectivity and Sensitivity

  摘要：

  A bicyclic cycloadduct 1 bearing a pyrenyl moiety has been synthesized and investigated as a ratiometric fluorescent sensor for AgI. In an aqueous ethanol solution of 1, the presence of silver ion induces the formation of a 1:2 metal-ligand complex, which exhibits a strong intensity enhancement of the pyrene excimer emission at the expense of the emission of monomeric pyrene.

  DOI：

  10.1021/ja029253d

文献信息

• Synthesis and Biological Activity of Isoxazolidinyl Polycyclic Aromatic Hydrocarbons:  Potential DNA Intercalators
  作者：Antonio Rescifina、Maria A. Chiacchio、Antonino Corsaro、Erik De Clercq、Daniela Iannazzo、Antonio Mastino、Anna Piperno、Giovanni Romeo、Roberto Romeo、Vincenza Valveri

  DOI：10.1021/jm050772b

  日期：2006.1.1

  Isoxazolidinyl polycyclic aromatic hydrocarbons (isoxazolidinyl-PAHs) have been synthesized in good yields by 1,3-dipolar cycloaddition methodology promoted by microwave irradiation. The structures of the obtained cycloadducts have been determined by NOE experiments and supported by computational studies at the AMI level. The cytotoxicity and antiviral activity of the synthesized compounds have been investigated. In particular, compounds 7c and 7e show high levels of cytotoxicity on MOLT-3 leukemia cells;, 7e exerts a remarkable enhancing activity on apoptosis caused by anti-fas antibody addition. Furthermore, compounds 7b and 8b exhibit specific antiviral effects against the Punta Toro virus.
• A Ratiometric Fluorescent Sensor for Ag^I with High Selectivity and Sensitivity
  作者：Rong-Hua Yang、Wing-Hong Chan、Albert W. M. Lee、Ping-Fang Xia、Hong-Kui Zhang、L

  DOI：10.1021/ja029253d

  日期：2003.3.1

  A bicyclic cycloadduct 1 bearing a pyrenyl moiety has been synthesized and investigated as a ratiometric fluorescent sensor for AgI. In an aqueous ethanol solution of 1, the presence of silver ion induces the formation of a 1:2 metal-ligand complex, which exhibits a strong intensity enhancement of the pyrene excimer emission at the expense of the emission of monomeric pyrene.