catechol monopropanoate | 131625-34-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: catechol monopropanoate
• 英文别名: methyl 2-hydroxyphenyl acetate；Propionsaeure-o-hydroxyphenylester；Hydroxyphenylpropionate；(2-hydroxyphenyl) propanoate
• CAS: 131625-34-8
• 化学式: C₉H₁₀O₃
• 分子量: 166.177
• InChiKey: YAPRWCFMWHUXRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,3-二氯丙烯 、 catechol monopropanoate 在 potassium carbonate 作用下， 以 甲醇 、 乙酸乙酯 为溶剂， 生成 methyl 2-(2-chloroprop-2-enyloxy)phenyl acetate
  参考文献：
  名称：

  Fungicides

  摘要：

  化学式为##STR1##及其立体异构体的化合物，其中A为氧或硫；Z和Y独立地为氢、卤素、可选取代的烷基、硝基或氰基；R含有至少一个卤素原子，是群##STR2##其中R.sup.1和R.sup.2独立地为氢或烷基；而R.sup.3、R.sup.4和R.sup.5独立地为氢、卤素、烷基、卤代烷基或烷氧基。

  公开号：

  US04895974A1
• 作为产物：
  描述：

  catechol dipropanoate 在 porcine pancreatic lipase 作用下， 以 苯 为溶剂， 反应 2.0h， 以20%的产率得到catechol monopropanoate
  参考文献：
  名称：

  Hydrolytic reactions on polyphenolic perpropanoates by porcine pancreatic lipase immobilized in microemulsion-based gels

  摘要：

  Porcine pancreatic lipase (PPL) has been immobilized in microemulsion-based gels (MBGs). Highly selective and efficient deacylation of di/trihydric phenolic perpropanoates has been observed on incubating them with immobilized PPL. These reactions can find general utility in Synthetic Organic Chemistry. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00411-8

文献信息

• [EN] NEW THIENOPYRIMIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVEAUX DÉRIVÉS DE THIÉNOPYRIMIDINE, PROCÉDÉ POUR LEUR PRÉPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：SERVIER LAB

  公开号：WO2015097123A1

  公开（公告）日：2015-07-02

  Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R12, X, A and n are as defined in the description.

  式（I）的化合物：其中R1、R2、R3、R4、R5、R6、R7、R12、X、A和n的定义如描述中所述。
• 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle
  申请人：Sekiguchi Yoshinori

  公开号：US20080318923A1

  公开（公告）日：2008-12-25

  It is intended to provide a drug which is efficacious against pathological conditions relating to arginine-vasopressin V1b receptor. More particularly speaking, it is intended to provide a drug which has a therapeutic or preventive effect on depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, hypertension, digestive diseases, drug addiction, epilepsy, brain infarction, brain ischemia, brain edema, head injury, inflammation, immune diseases, alopecia and so on. As the results of intensive studies, a novel 1,3-dihydro-2H-indol-2-one compound and a pyrrolidin-2-one compound fused with a heteroaromatic ring, which are highly selective antagonists of arginine-vasopressin V1b receptor, have high metabolic stabilities and show favorable brain penetration and high plasma concentrations, are found, thereby achieving the above objective.

  旨在提供一种对与精氨酸加压素V1b受体相关的病理状况具有疗效的药物。更具体地说，旨在提供一种对抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、消化系统疾病、药物成瘾、癫痫、脑梗死、脑缺血、脑水肿、头部损伤、炎症、免疫疾病、脱发等具有治疗或预防作用的药物。经过深入研究，发现了一种新颖的1,3-二氢-2H-吲哚-2-酮化合物和与杂芳环融合的吡咯烷-2-酮化合物，它们是高度选择性的精氨酸加压素V1b受体拮抗剂，具有高代谢稳定性，表现出有利的血脑屏障穿透和高血浆浓度，从而实现了上述目标。
• PYRROLO[2,3-d]PYRIMIDINE TROPOMYSIN-RELATED KINASE INHIBITORS
  申请人：Andrews Mark David

  公开号：US20120258950A1

  公开（公告）日：2012-10-11

  The present invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as Trk antagonists.

  本发明涉及式(I)化合物及其药学上可接受的盐，其中取代基如本文所述，并且它们在医学上的用途，特别是作为Trk拮抗剂。
• NOVEL POLY(ARALKYL KETONE)S AND METHODS OF PREPARING THE SAME
  申请人：Parthiban Anbanandam

  公开号：US20050272905A1

  公开（公告）日：2005-12-08

  Disclosed are processes for preparing modifiable poly(aralkyl ketone)s having active methylene group(s) in the main chain comprising reacting an aralkanoic acid or mixtures thereof in the presence of one alkane or aryl sulfonic acid and a condensing agent. Also disclosed are novel modifiable poly(aralkyl ketone)s obtainable by the processes of the inventions.

  揭示了一种制备具有主链中活性亚甲基基团的可修改聚芳基酮的方法，包括在一烷烃或芳基磺酸和缩合剂的存在下，反应芳基酸或其混合物。还揭示了通过所述发明的方法获得的新型可修改聚芳基酮。
• Hydroformylation of acyclic monoethylenically unsaturated compounds to corresponding terminal aldehydes
  申请人：——

  公开号：US20020013503A1

  公开（公告）日：2002-01-31

  A process for hydroformylatiog acyclic monoethylenically unsaturated compounds to corresponding terminal aldehydes using a Group VIII transition metal and selected multidentate phosphite ligands.

  一种使用第VIII族过渡金属和选择的多齿膦配体将无环单乙烯不饱和化合物氢甲酰化为相应的末端醛的方法。