2,3-Dimethylbutan-2-yl-[1-[2,3-dimethylbutan-2-yl(dimethyl)silyl]oxy-3-phenylmethoxypropan-2-yl]oxy-dimethylsilane | 196494-09-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-Dimethylbutan-2-yl-[1-[2,3-dimethylbutan-2-yl(dimethyl)silyl]oxy-3-phenylmethoxypropan-2-yl]oxy-dimethylsilane
• CAS: 196494-09-4
• 化学式: C₂₆H₅₀O₃Si₂
• 分子量: 466.852
• InChiKey: FMFZCIXCTNBDEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.89
• 重原子数：
  31
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  月桂酰氯 、 2,3-Dimethylbutan-2-yl-[1-[2,3-dimethylbutan-2-yl(dimethyl)silyl]oxy-3-phenylmethoxypropan-2-yl]oxy-dimethylsilane 在 四丁基氯化铵 作用下， 以 氯仿 为溶剂， 反应 5.0h， 以69%的产率得到
  参考文献：
  名称：

  Synthesis of Esters from Silyl Ethers and Acyl Chlorides: Catalysis by Quaternary Ammonium Chlorides.

  摘要：

  The formation of esters from silyl ethers and acyl chlorides is catalysed by quaternary ammonium chlorides, the other halide ions being less efficient. Evidence for the intermediacy of the alcohol formed by protodesilylation of the silyl ether is presented. Excellent regioselectivities (>99%) were obtained in the monoacylations of the bis-silyl ether 3 made from 1-O-benzylglycerol.

  DOI：

  10.3891/acta.chem.scand.51-0953
• 作为产物：
  描述：

  1-苄基-2,3-异亚丙基-rac-甘油 在 咪唑 、 水 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 19.0h， 生成 2,3-Dimethylbutan-2-yl-[1-[2,3-dimethylbutan-2-yl(dimethyl)silyl]oxy-3-phenylmethoxypropan-2-yl]oxy-dimethylsilane
  参考文献：
  名称：

  Synthesis of Esters from Silyl Ethers and Acyl Chlorides: Catalysis by Quaternary Ammonium Chlorides.

  摘要：

  The formation of esters from silyl ethers and acyl chlorides is catalysed by quaternary ammonium chlorides, the other halide ions being less efficient. Evidence for the intermediacy of the alcohol formed by protodesilylation of the silyl ether is presented. Excellent regioselectivities (>99%) were obtained in the monoacylations of the bis-silyl ether 3 made from 1-O-benzylglycerol.

  DOI：

  10.3891/acta.chem.scand.51-0953

文献信息

• Synthesis of Esters from Silyl Ethers and Acyl Chlorides: Catalysis by Quaternary Ammonium Chlorides.
  作者：Svante Brandänge、Hans Leijonmarck、Teclay Minassie、Steinar Husebye、Jose Maria Moreno、Antonio Romerosa、Ward T. Robinson、Björn O. Roos、Claire Vallance、Bryan R. Wood

  DOI：10.3891/acta.chem.scand.51-0953

  日期：——

  The formation of esters from silyl ethers and acyl chlorides is catalysed by quaternary ammonium chlorides, the other halide ions being less efficient. Evidence for the intermediacy of the alcohol formed by protodesilylation of the silyl ether is presented. Excellent regioselectivities (>99%) were obtained in the monoacylations of the bis-silyl ether 3 made from 1-O-benzylglycerol.