3-tert-butyldiphenylsilyloxybenzyl bromide | 271580-83-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-tert-butyldiphenylsilyloxybenzyl bromide
• 英文别名: [3-(Bromomethyl)phenoxy]-tert-butyl-diphenylsilane；[3-(bromomethyl)phenoxy]-tert-butyl-diphenylsilane
• CAS: 271580-83-7
• 化学式: C₂₃H₂₅BrOSi
• 分子量: 425.44
• InChiKey: KCGQDYVOGMJBQD-UHFFFAOYSA-N

物化性质

• 沸点：
  447.0±37.0 °C(predicted)
• 密度：
  1.22±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.52
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-tert-butyldiphenylsilyloxybenzyl bromide 在 正丁基锂 、 W-2 Raney nickel 、 四丁基氟化铵 、 potassium carbonate 、 potassium iodide 作用下， 以 四氢呋喃 、 乙醇 、 正己烷 、 丙酮 为溶剂， 反应 15.0h， 生成 (+/-)-2-(3-ethoxycarbonylmethoxybenzyl)-3-(3'-hydroxybenzyl)butyrolactone
  参考文献：
  名称：

  Development of a Novel Hapten for Radioimmunoassay of the Lignan, Enterolactone in Plasma (Serum). Total Synthesis of (±)-trans-5-Carboxymethoxyenterolactone and Several Analogues

  摘要：

  A recently developed method for the analysis of the mammalian lignan, enterolactone 1, is based on time-resolved fluoroimmunoassay (TR-FIA) using an europium chelate as a label. This RIA utilizes enterolactone derivatives carrying a carboxylic acid appendage for the production of antiserum and tracer. The synthesis of 5-carboxymethoxyenterolactone 6 and analogues 5, 7 and 8 is described, and their suitability for the method are discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00078-8
• 作为产物：
  描述：

  3-((tert-butyldiphenylsilyl)oxy)benzaldehyde 在 sodium tetrahydroborate 、 三溴化磷 作用下， 以 乙醚 、 乙醇 为溶剂， 反应 52.0h， 生成 3-tert-butyldiphenylsilyloxybenzyl bromide
  参考文献：
  名称：

  Development of a Novel Hapten for Radioimmunoassay of the Lignan, Enterolactone in Plasma (Serum). Total Synthesis of (±)-trans-5-Carboxymethoxyenterolactone and Several Analogues

  摘要：

  A recently developed method for the analysis of the mammalian lignan, enterolactone 1, is based on time-resolved fluoroimmunoassay (TR-FIA) using an europium chelate as a label. This RIA utilizes enterolactone derivatives carrying a carboxylic acid appendage for the production of antiserum and tracer. The synthesis of 5-carboxymethoxyenterolactone 6 and analogues 5, 7 and 8 is described, and their suitability for the method are discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00078-8

文献信息

• Development of a Novel Hapten for Radioimmunoassay of the Lignan, Enterolactone in Plasma (Serum). Total Synthesis of (±)-trans-5-Carboxymethoxyenterolactone and Several Analogues
  作者：Taru Mäkelä、Jorma Matikainen、Kristiina Wähälä、Tapio Hase

  DOI：10.1016/s0040-4020(00)00078-8

  日期：2000.3

  A recently developed method for the analysis of the mammalian lignan, enterolactone 1, is based on time-resolved fluoroimmunoassay (TR-FIA) using an europium chelate as a label. This RIA utilizes enterolactone derivatives carrying a carboxylic acid appendage for the production of antiserum and tracer. The synthesis of 5-carboxymethoxyenterolactone 6 and analogues 5, 7 and 8 is described, and their suitability for the method are discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.