2-(phenylamino)-2-thiooxoacetamide | 90345-46-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(phenylamino)-2-thiooxoacetamide
• 英文别名: N¹-phenyl-thiooxalamide；N¹-Phenyl-thiooxalamid；Thiooxanilsaeure-amid；Thiooxalsaeure-amid-anilid；Thiooxanilamid；2-(Phenylamino)-2-thioxoacetamide；2-anilino-2-sulfanylideneacetamide
• CAS: 90345-46-3
• 化学式: C₈H₈N₂OS
• mdl: MFCD00490775
• 分子量: 180.23
• InChiKey: OXZFBJIZFIIAKX-UHFFFAOYSA-N

物化性质

• 熔点：
  167 °C(Solv: ethanol (64-17-5))
• 沸点：
  318.4±25.0 °C(Predicted)
• 密度：
  1.373±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(phenylamino)-2-thiooxoacetamide 在 sodium hydroxide 、 potassium hexacyanoferrate(III) 作用下， 以 水 为溶剂， 反应 1.0h， 以70%的产率得到2-苯并噻唑甲酰胺
  参考文献：
  名称：

  用于OLED的新型hetero杂芳族羧酸酯的设计

  摘要：

  提出了定向合成镧系元素芳族羧酸盐（电致发光材料的前体）的方法，即增加共轭长度和在适当位置结合中性配体引入杂原子。这导致了一系列新的镧系元素络合物的分离，其中在溶液加工的OLED中混合配体苯并噻唑-2-羧酸carboxy与邻菲咯啉获得了最高的电致发光效率。能量传递过程的特殊性允许获得基于该系统的发光温度计材料，这在生理范围内使灵敏度降低了2.8％/ K。

  DOI：

  10.1016/j.dyepig.2019.107604
• 作为产物：
  描述：

  oxanilic acid thioamide 在 diphosphorus pentasulfide 、 xylene 、 potassium hexacyanoferrate(III) 作用下， 生成 2-(phenylamino)-2-thiooxoacetamide
  参考文献：
  名称：

  Reissert, Chemische Berichte, 1904, vol. 37, p. 3730

  摘要：

  DOI：

文献信息

• Aminophenoxyacetamide derivatives and pharmaceutical composition containing thereof
  申请人：——

  公开号：US20030139447A1

  公开（公告）日：2003-07-24

  There is provided an aminophenoxyacetamide derivative of the formula (I): wherein, R 1 to R 4 are, independent from each other, hydrogen atom; optionally substituted alkyl group; E 1 is —NR 4 — and E 2 is oxygen atom or —NR 10 ; Q is group —X—Y—Q′ (X and Y are connecting bond; X is alkylene or alkenylene group, etc.; Y is selected from the groups consisting of C═O, NHC(═O), C(═O)NH, etc.; Q′ is hydrogen atom or pheny, pyridyl groups which may be substituted, etc.), or a pharmaceutically acceptable salt thereof. These compounds have neuroprotective effect by introducing the CalbindinD-28k, one of Ca 2+ -binding proteins. 11

  提供了一种氨基苯氧乙酰胺衍生物，其化学式为(I)：其中，R1至R4独立地为氢原子；可选择取代的烷基基团；E1为—NR4—，E2为氧原子或—NR10；Q为基团—X—Y—Q′（X和Y为连接键；X为烷基或烯基基团等；Y选自由C═O、NHC(═O)、C(═O)NH等组成的基团；Q′为氢原子或苯基、可取代的吡啶基团等），或其药学上可接受的盐。这些化合物通过引入钙结合蛋白之一的CalbindinD-28k具有神经保护作用。
• Non-toxic corrosion-protection pigments based on manganese
  申请人：——

  公开号：US20040011252A1

  公开（公告）日：2004-01-22

  Corrosion-inhibiting pigments based on manganese are described that contain a trivalent or tetravalent manganese/valence stabilizer complex. An inorganic or organic material is used to stabilize the trivalent or tetravalent manganese ion to form a compound that is sparingly soluble, exhibits low solubility, or is insoluble in water, depending upon the intended usage. Specific stabilizers are chosen to control the release rate of trivalent or tetravalent manganese during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Manganese/valence stabilizer combinations are chosen based on the well-founded principles of manganese coordination chemistry. Many manganese-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium or tetravalent lead systems. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

  以锰为基础的缓蚀颜料含有三价或四价锰/价稳定剂复合物。一种无机或有机材料可用于稳定三价或四价锰离子，从而形成一种可少量溶解、溶解度低或不溶于水的化合物，具体取决于预期用途。选择特定的稳定剂是为了控制三价锰或四价锰在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。锰/价稳定剂组合的选择是基于锰配位化学的基本原理。文中介绍了许多锰价稳定剂组合，其性能与传统的六价铬或四价铅体系相当。需要强调的是，提供本摘要是为了符合要求提供摘要的规则，以便检索者或其他读者快速确定技术公开的主题。提交本摘要的前提是，本摘要不用于解释或限制权利要求的范围或含义。
• Non-toxic corrosion-protection pigments based on rare earth elements
  申请人：——

  公开号：US20040104377A1

  公开（公告）日：2004-06-03

  A corrosion-inhibiting pigment comprising a rare earth element and a valence stabilizer combinded to form a rare earth/valence stabilizer complex. The rare earth element is selected from cerium, terbium, praseodymium, or a combination thereof, and at least one rare earth element is in the tetravalent oxidation state. An inorganic or organic material is used to stabilize the tetravalent rare earth ion to form a compound that is sparingly soluble in water. Specific stabilizers are chosen to control the release rate of tetravalent cerium, terbium, or praseodymium during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Many rare earth-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium systems.

  一种缓蚀颜料，由稀土元素和价态稳定剂结合形成稀土/价态稳定剂复合物。稀土元素选自铈、铽、镨或它们的组合，至少有一种稀土元素处于四价氧化态。使用无机或有机材料来稳定四价稀土离子，以形成稀溶于水的化合物。选择特定的稳定剂是为了控制四价铈、铽或镨在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。本文介绍了许多稀土-价稳定剂组合，其性能可与传统的六价铬体系媲美。
• Thiel, W.; Mayer, R., Journal fur praktische Chemie (Leipzig 1954), 1989, vol. 331, # 2, p. 243 - 262
  作者：Thiel, W.、Mayer, R.

  DOI：——

  日期：——
• 594. The conversion of carbamoylmethyl thiolsulphates into thio-oxamides; a new variant of the Willgerodt–Kindler reaction
  作者：Brian Milligan、J. M. Swan

  DOI：10.1039/jr9590002969

  日期：——