3-Amino-6-methyl-4-phenylthieno[2,3-b]pyridine-2-carboxamide | 94638-98-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-Amino-6-methyl-4-phenylthieno[2,3-b]pyridine-2-carboxamide
• CAS: 94638-98-9
• 化学式: C₁₅H₁₃N₃OS
• 分子量: 283.354
• InChiKey: FISLKDJWUZKKNJ-UHFFFAOYSA-N

物化性质

• 熔点：
  209-210 °C(Solvent: Ethyl acetate)
• 沸点：
  531.1±50.0 °C(Predicted)
• 密度：
  1.357±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-Amino-6-methyl-4-phenylthieno[2,3-b]pyridine-2-carboxamide 生成 ethyl 11-methyl-6-oxo-13-phenyl-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),4,9,11-pentaene-4-carboxylate
  参考文献：
  名称：

  VIEWEG, HELMUT;LEISTNER, SIEGFRIED;WAGNER, GUNTHER;KRASSELT, UWE;LOHMANN,+

  摘要：

  DOI：
• 作为产物：
  描述：

  6-methyl-4-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile 在 氢氧化钾 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.25h， 生成 3-Amino-6-methyl-4-phenylthieno[2,3-b]pyridine-2-carboxamide
  参考文献：
  名称：

  Condensed pyridines

  摘要：

  DOI：

  10.1007/bf00960275

文献信息

• [EN] SUBSTITUTED 3-AMINO-THIENO[2,3-B] PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AS IKK INHIBITORS<br/>[FR] COMPOSES AMIDE D'ACIDE 3-AMINO-THIENO[2,3-B] PYRIDINE-2-CARBOXYLIQUE SUBSTITUE SERVANT D'INHIBITEURS D'IKK
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2005056562A1

  公开（公告）日：2005-06-23

  Disclosed are compounds of formula (I): wherein the variables R1, R2, R3 and Z are described herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

  披露了公式(I)的化合物：其中变量R1、R2、R3和Z如本文所述，它们作为IκB激酶(IKK)复合物的激酶活性的抑制剂是有用的。因此，这些化合物在治疗IKK介导的疾病，包括自身免疫性疾病、炎症性疾病和癌症方面是有用的。还披露了包含这些化合物的药物组合物以及制备这些化合物的方法。
• [EN] SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES<br/>[FR] COMPOSES AMIDE D'ACIDE 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIQUE SUBSTITUES ET PROCESSUS DE PREPARATION ET D'UTILISATION DE CES COMPOSES
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2003103661A1

  公开（公告）日：2003-12-18

  Disclosed are compounds of formula (I), wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

  公开的是式(I)的化合物，其中R1和R2如本文所定义，这些化合物可用作IκB激酶（IKK）复合物激酶活性的抑制剂。因此，这些化合物在治疗IKK介导的疾病，包括自身免疫疾病、炎症性疾病和癌症方面是有用的。还公开了包含这些化合物的药物组合物以及制备这些化合物的方法。
• SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES
  申请人：GINN David John

  公开号：US20070293533A1

  公开（公告）日：2007-12-20

  Disclosed are compounds of formula (I): wherein R 1 and R 4 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases, cardiovascular disease and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

  公开了以下化合物的结构（I）：其中R1和R4如本文所定义，这些化合物可用作IκB激酶（IKK）复合物的激酶活性抑制剂。因此，这些化合物在治疗IKK介导的疾病中具有用途，包括自身免疫性疾病、炎症性疾病、心血管疾病和癌症。还公开了包含这些化合物的药物组合物和制备这些化合物的方法。
• Therapeutic agents
  申请人：Alstermark Lindstedt Eva-Lotte

  公开号：US20050131068A1

  公开（公告）日：2005-06-16

  The present invention provides the S enantiomer of a compound of formula I wherein R 1 represents chloro, trifluoromethyl or trifluoromethoxy, R 2 represents H or fluoro and R 3 represents a C 2-4 alkyl group as well as pharmaceutically acceptable salts, solvates and prodrugs thereof, to processes for preparing such compounds, to their the utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.

  本发明提供了公式I的化合物的S对映体，其中R1代表氯、三氟甲基或三氟甲氧基，R2代表H或氟，R3代表C2-4烷基，以及其药学上可接受的盐、溶剂化合物和前药。本发明还提供了制备这些化合物的方法，它们在治疗包括脂质紊乱（失调）的临床病症中的用途，无论是否与胰岛素抵抗相关，以及它们的治疗用途的方法和包含它们的制药组合物。
• Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
  申请人：Chen Zhidong

  公开号：US20050182053A1

  公开（公告）日：2005-08-18

  Disclosed are compounds of formula (I): wherein the variables R 1 , R 2 , R 3 and Z are described herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

  本发明公开了式（I）的化合物：其中变量R1，R2，R3和Z如下所述，其可用作IκB激酶（IKK）复合物的激酶活性抑制剂。 因此，这些化合物可用于治疗IKK介导的疾病，包括自身免疫性疾病、炎症性疾病和癌症。 还公开了包含这些化合物的制药组合物和制备这些化合物的过程。