2-imidazole-1-yl-N-(4-methoxyphenyl)acetamide | 72502-30-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-imidazole-1-yl-N-(4-methoxyphenyl)acetamide
• 英文别名: 2-imidazol-1-yl-N-(4-methoxyphenyl)acetamide
• CAS: 72502-30-8
• 化学式: C₁₂H₁₃N₃O₂
• mdl: MFCD11783420
• 分子量: 231.254
• InChiKey: PYFQBOCNOXVNPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  56.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-imidazole-1-yl-N-(4-methoxyphenyl)acetamide 、 二溴甲烷 以 四氢呋喃 为溶剂， 反应 72.0h， 以60.8%的产率得到1,1'-methylene-bis(3-N-(4-methoxyphenyl)acetamide-1H-imidazolium) dibromide
  参考文献：
  名称：

  Platinum(II) complexes with amide-functionalized NHC ligands

  摘要：

  We present the synthesis of neutral, amide-functionalized N-heterocyclic carbene (NHC) platinum(II) complexes with dianionic -N-C-NHC-C-NHC-N- (NC*C*N) tetradentate ligands. The imidazolium- and bisimidazolium bromide NHC ligand precursors with amide functionality in the side chain are reported together with the corresponding biscarbene bromido complexes and, after deprotonation, of the neutral NHC complexes without counterions. All compounds have been thoroughly characterized by standard techniques. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2012.05.019
• 作为产物：
  描述：

  甲氧苯胺 在 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 2.0h， 生成 2-imidazole-1-yl-N-(4-methoxyphenyl)acetamide
  参考文献：
  名称：

  Platinum(II) complexes with amide-functionalized NHC ligands

  摘要：

  We present the synthesis of neutral, amide-functionalized N-heterocyclic carbene (NHC) platinum(II) complexes with dianionic -N-C-NHC-C-NHC-N- (NC*C*N) tetradentate ligands. The imidazolium- and bisimidazolium bromide NHC ligand precursors with amide functionality in the side chain are reported together with the corresponding biscarbene bromido complexes and, after deprotonation, of the neutral NHC complexes without counterions. All compounds have been thoroughly characterized by standard techniques. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2012.05.019

文献信息

• Bisamidate-functionalized NHC ligands: Electronic and steric influences of N-substituents on the bisamidate moieties
  作者：Yurina Hirota、Shin Ando、Tadao Ishizuka

  DOI：10.1016/j.tet.2022.132668

  日期：2022.2

  DHASIs, to synthesize various bisamide functionalized NHC pincer ligand precursors, and their Pd complexes also were successfully obtained. The structures of the synthesized complexes were unambiguously confirmed via XRD study, which showed that the N-substituents had a structural affect via the coordination modes of the resultant complexes. We applied the obtained pincer complexes to a Suzuki Miyaura

  双阴离子束缚 NHC 配体已广泛用作稳定和有用的催化剂。阴离子供体位点的特性使其可用于调节金属配合物与 NHC 配体，并且由于酰胺配体可以在其氮元素上官能化，它们也已被用作催化剂。然而，很少有关于各种 N-取代基对双酰胺酸酯官能化 NHC 中双酰胺酸酯部分的影响的研究。在本研究中，我们使用原始的NHCs，我们称之为DHASIs，合成了各种双酰胺功能化的NHC钳形配体前体，并成功获得了它们的Pd配合物。通过XRD研究明确证实了合成配合物的结构，这表明N-取代基通过所得配合物的配位模式具有结构影响。我们将获得的钳形配合物应用于 Suzuki Miyaura 偶联反应，发现阴离子 N 供体的强路易斯碱性提高了 Pd-NCN 钳形配合物的催化性能。
• Platinum(II) complexes with amide-functionalized NHC ligands
  作者：Yvonne Unger、Thomas Strassner

  DOI：10.1016/j.jorganchem.2012.05.019

  日期：2012.8

  We present the synthesis of neutral, amide-functionalized N-heterocyclic carbene (NHC) platinum(II) complexes with dianionic -N-C-NHC-C-NHC-N- (NC*C*N) tetradentate ligands. The imidazolium- and bisimidazolium bromide NHC ligand precursors with amide functionality in the side chain are reported together with the corresponding biscarbene bromido complexes and, after deprotonation, of the neutral NHC complexes without counterions. All compounds have been thoroughly characterized by standard techniques. (C) 2012 Elsevier B. V. All rights reserved.