vinyl phenyl selenide | 35167-28-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: vinyl phenyl selenide
• 英文别名: phenyl vinyl selenide；phenyl(vinyl)selane；Benzene, (ethenylseleno)-；ethenylselanylbenzene
• CAS: 35167-28-3
• 化学式: C₈H₈Se
• 分子量: 183.112
• InChiKey: NBMSKGMDYVDYLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.16
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  vinyl phenyl selenide 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 0.17h， 生成
  参考文献：
  名称：

  Selenium stabilized carbanions. Acidity of allyl and vinyl sulfides and selenides

  摘要：

  DOI：

  10.1021/jo01313a050
• 作为产物：
  描述：

  ethynyl(phenyl)selane 在 Schwartz's reagent 、 水 作用下， 生成 vinyl phenyl selenide
  参考文献：
  名称：

  Hydrozirconation of acetylenic chalcogenides. Synthesis and reactions of zirconated vinyl chalcogenide intermediates

  摘要：

  Acetylenic tellurides react with Cp2Zr(H)Cl in THF at room temperature to give the alpha-zirconated vinyl telluride intermediates 39, which react with a wide range of electrophiles to give several types of trisubstituted olefins, such as alpha-halo vinyl tellurides, ketene telluro(seleno) acetals, ketene telluro acetals, and vinylic tellurides of Z configuration. Acetylenic selenides undergo similar reactions, but a lack of regioselectivity results in the formation of a mixture of alpha-zirconated 19 and beta- zirconated 20 vinylic selenide intermediates. After a derailed study was established that the use of 2.0 equivalents of Cp2Zr(H)Cl is crucial to perform the total hydrozirconation of acetylenic selenides or tellurides. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00014-3

文献信息

• An efficient metal-free pathway to vinyl thioesters with calcium carbide as the acetylene source
  作者：Konstantin S. Rodygin、Valentine P. Ananikov

  DOI：10.1039/c5gc01552a

  日期：——

  Chemical reactions involving high-pressure acetylene are not easily performed in a standard laboratory setup. The risk of explosion and technical difficulties drastically complicate the equipment and greatly increase the cost....

  在标准实验室设置中，不容易进行涉及高压乙炔的化学反应。爆炸的危险和技术难题极大地使设备复杂化，并大大增加了成本。
• [EN] MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE<br/>[FR] INHIBITEURS DE MCL-1 MACROCYCLIQUE ET PROCÉDÉS D'UTILISATION
  申请人：ABBVIE INC

  公开号：WO2019035927A1

  公开（公告）日：2019-02-21

  The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

  本公开提供了Formula (I)中A2、A3、A4、A6、A7、A8、A15、RA、R5、R9、R10A、R10B、R11、R12、R13、R14、R16、W、X和Y的化合物，这些化合物的任何值均在规范中定义，并且其药学上可接受的盐，可用作治疗疾病和病况，包括癌症的药物。还提供了包含Formula (I)中化合物的药物组合物。
• One-Pot Synthesis of Pyrrolo[2,1-α]isoquinolines via Tandem Reactions of Vinylselenonium Salt, 2-Bromoethanones, and Isoquinoline
  作者：E Tang、Deshou Mao、Qi Sun、Minghong Liao、Yunxia Li、Shanshan Liu

  DOI：10.3987/com-19-14162

  日期：——

  3-unsubstituted pyrrolo[2,1-a]isoquinolines efficiently. Herein, we report a tandem reaction of the methyl(phenyl)vinylselenonium salt with isoquinoline and 2-bromoethanones to access 2,3-unsubstituted pyrrolo[2,1-α]isoquinolines efficiently and conveniently under mild conditions and in moderate to good yields. To the best of our knowledge, this is the first reported one-pot synthesis of the pyrrolo[2,1-a]isoquinolines

  通过甲基(苯基)乙烯基硒盐与异喹啉和2-溴乙酮的串联反应，开发了一种方便的一锅法合成吡咯并[2,1-a]异喹啉，具有条件温和、底物可用、实验步骤简单等特点。 ，中等至良好的产量，以及广泛的官能团耐受性。吡咯并[2,1-a]异喹啉衍生物作为一类重要的含氮杂环化合物，广泛存在于海藻毒素、1e片层碱、1f和果酱1g等海洋生物碱中，并具有广泛的生物活性，2a-d如抗炎、心血管、抗抑郁、抗癌和 HIV-1 整合酶抑制活性。吡咯并[2,1-a]异喹啉在材料科学中也有应用，如有机发光器件、生物标记和染料。2e-g 因此，1-a]异喹啉很少，通常需要多个步骤和特殊的烯烃底物，如硝基烯酮二硫缩醛。 5g,h 徐氏课题组通过级联反应得到2,3-未取代的1-酰基吡咯并[2,1-a]异喹啉异喹啉叶立德和马来酸酐之间的关系，包括 1,3-偶极环加成反应、氧化双脱羧反应和随后的脱氢芳构化反应。9 然而，这种优雅的方法
• [EN] MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE<br/>[FR] INHIBITEURS MACROCYCLIQUES DE MCL-1 ET MÉTHODES D'UTILISATION
  申请人：ABBVIE INC

  公开号：WO2019035911A1

  公开（公告）日：2019-02-21

  The present disclosure provides for compounds of formula (I), wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).

  本公开提供了式(I)的化合物，其中A2、A3、A4、A6、A7、A8、A15、RA、R5、R9、R10A、R10B、R11、R12、R13、R14、R16、W、X和Y具有规范中定义的任何值，以及其药学上可接受的盐，这些化合物在治疗疾病和病况，包括癌症方面是有用的。还提供了包含式(I)化合物的药物组合物。
• Synthesis of Enantiopure 1,4-Dioxanes, Morpholines, and Piperazines from the Reaction of Chiral 1,2-Diols, Amino Alcohols, and Diamines with Vinyl Selenones
  作者：Luana Bagnoli、Catalina Scarponi、Maria Giovanna Rossi、Lorenzo Testaferri、Marcello Tiecco

  DOI：10.1002/chem.201002593

  日期：2011.1.17

  selenones with enantiopure 1,2‐diols, N‐protected‐1,2‐aminoalcohols, and diamines gave substituted enantiopure 1,4‐dioxanes, morpholines, and piperazines, respectively, in good to excellent yields. The same procedure was extended to the synthesis of thiomorpholine, benzodiazepine, and benzoxazepine. The reactions proceeded in one pot, in the presence of base, through a simple and novel application of the

  容易获得的乙烯基硒酮与对映纯1,2-二醇，N-保护的1,2-氨基醇和二胺的反应分别得到了对映体纯的1,4-二恶烷，吗啉和哌嗪，收率良好至极佳。相同的程序扩展到了硫吗啉，苯并二氮杂卓和苯并x氮平的合成。通过简单，新颖地应用迈克尔引发的闭环（MIRC）反应，在碱存在的情况下，该反应在一个罐中进行。形成的杂环构成在许多药物化合物中观察到的骨架。