1-Tert-butoxy-4-methyl-2-nitrobenzene | 142596-55-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Tert-butoxy-4-methyl-2-nitrobenzene
• 英文别名: 4-methyl-1-[(2-methylpropan-2-yl)oxy]-2-nitrobenzene
• CAS: 142596-55-2
• 化学式: C₁₁H₁₅NO₃
• 分子量: 209.245
• InChiKey: YFDINFAXPXAYFW-UHFFFAOYSA-N

物化性质

• 沸点：
  311.8±22.0 °C(Predicted)
• 密度：
  1.094±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氟-3-硝基甲苯 、 potassium tert-butylate 以 四氢呋喃 为溶剂， 反应 2.0h， 以92%的产率得到1-Tert-butoxy-4-methyl-2-nitrobenzene
  参考文献：
  名称：

  A Simple and Efficient Method for the Preparation of Hindered Alkyl−Aryl Ethers

  摘要：

  DOI：

  10.1021/jo981647t

文献信息

• Hydrogel Prodrugs
  申请人：ASCENDIS PHARMA A/S

  公开号：US20150258205A1

  公开（公告）日：2015-09-17

  The present invention relates to a process for the preparation of a hydrogel and to a hydrogel obtainable by said process. The present invention further relates to a process for the preparation of a hydrogel-spacer conjugate, to a hydrogel-spacer conjugate obtainable by said process, to a process for the preparation of a carrier-linked prodrug and to carrier-linked prodrugs obtainable by said process, in particular to carrier-linked prodrugs that provide for a controlled or sustained release of a drug from a carrier. In addition, the invention relates to the use of the hydrogel for the preparation of a carrier-linked prodrug.

  本发明涉及一种制备水凝胶的方法，以及通过该方法可获得的水凝胶。本发明还涉及一种制备水凝胶-间隔物共轭物的方法，以及通过该方法可获得的水凝胶-间隔物共轭物，还涉及一种制备载体连结的前药的方法，以及通过该方法可获得的载体连结的前药，特别是提供了能够从载体中控制或持续释放药物的载体连结的前药。此外，本发明涉及使用水凝胶制备载体连结的前药。
• PREVENTION AND TREATMENT OF OCULAR CONDITIONS
  申请人：Ascendis Pharma Growth Disorders Division A/S

  公开号：US20170112939A1

  公开（公告）日：2017-04-27

  The present invention relates to pharmaceutical compositions comprising hydrogel-linked prodrug for use in the treatment, prevention and/or diagnosis a condition of the eye and ophthalmic devices comprising said pharmaceutical compositions.

  本发明涉及含有水凝胶连接的前药的药物组合物，用于治疗、预防和/或诊断眼部疾病，并且包括该药物组合物的眼科设备。
• NOVEL OPTICAL LABELING MOLECULES FOR PROTEOMICS AND OTHER BIOLOGICAL ANALYSIS
  申请人：Montana State University

  公开号：US20140186875A1

  公开（公告）日：2014-07-03

  The invention relates to compositions and methods useful in the labeling and identification of changes in protein levels, changes in enzyme activity, and changes in protein modification. The invention provides for highly soluble optical labeling molecules which are optionally cleavable after separation of mixtures of labeled proteins into components. These optical labeling molecules find utility in a variety of applications, including use in the field of proteomics.

  本发明涉及用于标记和识别蛋白质水平变化、酶活性变化和蛋白质修饰变化的组合物和方法。本发明提供了高度溶解的光学标记分子，这些分子在将标记的蛋白质混合物分离成组分后可以选择性地被切割。这些光学标记分子在各种应用中具有实用性，包括在蛋白质组学领域中的应用。
• Protein Carrier-Linked Prodrugs
  申请人：Hersel Ulrich

  公开号：US20140323402A1

  公开（公告）日：2014-10-30

  The present invention relates to water-soluble protein carrier-linked prodrugs wherein the protein carrier comprises an amino acid sequence consisting of at least 100 amino acid residues forming random coil conformation and comprising alanine, serine and proline residues. It further relates to pharmaceutical compositions comprising said water-soluble protein carrier-linked prodrugs, their use as a medicament as well as methods of treatment and administration.

  本发明涉及水溶性蛋白质载体连接的前药，其中蛋白质载体包括由至少100个氨基酸残基组成的氨基酸序列，形成随机卷曲构象，并包括丙氨酸，丝氨酸和丙氨酸残基。它还涉及包含所述水溶性蛋白质载体连接的前药的制药组合物，它们作为药物的使用以及治疗和管理的方法。
• VEGF Neutralizing Prodrugs for the Treatment of Ocular Conditions
  申请人：Ascendis Pharma Ophthalmology Division A/S

  公开号：US20150297740A1

  公开（公告）日：2015-10-22

  The present invention relates to a pharmaceutical composition comprising one or more pharmaceutically acceptable excipient(s) and a VEGF neutralizing prodrug, which comprises a VEGF neutralizing biologically active moiety, for use in a method for the treatment of one or more ocular conditions.

  本发明涉及一种药物组合物，包括一种或多种药学上可接受的辅料和一种VEGF中和前药，该中和前药包括一种VEGF中和生物活性基团，用于治疗一种或多种眼部疾病的方法。