3,4-dipentylpyridine | 1190206-26-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3,4-dipentylpyridine
• CAS: 1190206-26-8
• 化学式: C₁₅H₂₅N
• 分子量: 219.37
• InChiKey: NOBPOOFSUBRCGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3,4-二甲基吡啶 、 正溴丁烷 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 21.0h， 以31%的产率得到3-methyl-4-pentylpyridine
  参考文献：
  名称：

  Synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes

  摘要：

  A series of bis(alkylpyridinium)alkanes with a twelve carbon spacer between the positive charges was synthesised and their antifungal activity has been investigated. Compounds with 2-pentyl, 4-pentyl, 4-hexyl, 4-octyl, 4-propylbenzene, 3,4-dipentyl, 4-(5'-nonyl) and 3-methyl, 4-pentyl head groups were the most potent antifungal agents with MICs in the range of 1.4-2.7 mu M against reference strains of both Cryptococcus neoformans and Candida albicans. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.07.037

文献信息

• [EN] VETERINARY METHOD AND COMPOSITION<br/>[FR] MÉTHODE ET COMPOSITION VÉTÉRINAIRES
  申请人：PFIZER LTD

  公开号：WO2007129169A2

  公开（公告）日：2007-11-15

  [EN] Inhibitors of COX-II are useful for improving reproductive success in female animals.
  [FR] L'invention concerne des inhibiteurs de COX-II utiles pour améliorer la réussite de reproduction chez des animaux femelles.
• Synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes
  作者：Daniel Obando、Namfon Pantarat、Rosemary Handke、Yasuko Koda、Fred Widmer、Julianne T. Djordjevic、David H. Ellis、Tania C. Sorrell、Katrina A. Jolliffe

  DOI：10.1016/j.bmc.2009.07.037

  日期：2009.9.1

  A series of bis(alkylpyridinium)alkanes with a twelve carbon spacer between the positive charges was synthesised and their antifungal activity has been investigated. Compounds with 2-pentyl, 4-pentyl, 4-hexyl, 4-octyl, 4-propylbenzene, 3,4-dipentyl, 4-(5'-nonyl) and 3-methyl, 4-pentyl head groups were the most potent antifungal agents with MICs in the range of 1.4-2.7 mu M against reference strains of both Cryptococcus neoformans and Candida albicans. (C) 2009 Elsevier Ltd. All rights reserved.