1-Phenyl-3-(3-methylpyridin-4-yl)-propan | 113003-48-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-Phenyl-3-(3-methylpyridin-4-yl)-propan
• 英文别名: 3-methyl-4-(3-phenylpropyl)pyridine；1-phenyl-3-(3-methyl-pyridin-4-yl)-propane；1-phenyl-3-(3-methyl-4-pyridyl)-propane
• CAS: 113003-48-8
• 化学式: C₁₅H₁₇N
• 分子量: 211.307
• InChiKey: NKRLVUXBPMSVBN-UHFFFAOYSA-N

物化性质

• 沸点：
  106 °C(Press: 0.02 Torr)
• 密度：
  1.011±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Phenyl-3-(3-methylpyridin-4-yl)-propan 在 sodium hydroxide 、 sodium tetrahydroborate 作用下， 以 乙醇 、 丙酮 为溶剂， 反应 26.5h， 生成 1,3-dimethyl-4-(3-phenylpropyl)-1,2,5,6-tetrahydropyridine
  参考文献：
  名称：

  Intramolekulare Aromatenalkylierungen, 18. Mitt. Synthese von 3,4-Dihydro-1′-methylspiro[naphthalin-1(2H), 4′-piperidinen]

  摘要：

  AbstractAus den Tetrahydropyridinen 10 entstehen in siedender Bromwasserstoffsäure stereoselektiv die Titelverbindungen 12, deren Struktur und Konfiguration durch NMR‐Spektroskopie und Röntgenstrukturanalyse bewiesen wird. Die Vorstufen 10 werden aus den Pyridincarbonitrilen 5 und den Grignardreagenzien 6 nach Standardverfahren gewonnen.

  DOI：

  10.1002/ardp.19873200502
• 作为产物：
  描述：

  3-甲基-4-氰基吡啶 在 氢氧化钾 、 一水合肼 、 magnesium 作用下， 以 various solvent(s) 为溶剂， 反应 7.0h， 生成 1-Phenyl-3-(3-methylpyridin-4-yl)-propan
  参考文献：
  名称：

  Intramolekulare Aromatenalkylierungen, 18. Mitt. Synthese von 3,4-Dihydro-1′-methylspiro[naphthalin-1(2H), 4′-piperidinen]

  摘要：

  AbstractAus den Tetrahydropyridinen 10 entstehen in siedender Bromwasserstoffsäure stereoselektiv die Titelverbindungen 12, deren Struktur und Konfiguration durch NMR‐Spektroskopie und Röntgenstrukturanalyse bewiesen wird. Die Vorstufen 10 werden aus den Pyridincarbonitrilen 5 und den Grignardreagenzien 6 nach Standardverfahren gewonnen.

  DOI：

  10.1002/ardp.19873200502

文献信息

• Pyridine derivatives and insecticide and miticide comprising said
  申请人：Idemitsu Kosan Co., Ltd.

  公开号：US05262420A1

  公开（公告）日：1993-11-16

  A pyridine compound of the formula ##STR1## wherein X is a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxyl group having 1 to 4 carbon atoms, a haloalkyl group having 1 to 4 carbon atoms or a haloalkoxyl group having 1 to 4 carbon atoms, n is 1 to 5, and when n is 2 or more, Xs may be identical to or different from each other, A is an alkyl residue or alkene residue in which a portion connecting the aryl group with the 4-position of the pyridyl group has 3 to 8 carbon atoms, or an alkapolyene residue in which said portion has 4 to 8 carbon atoms and 2 to 4 double bonds; the alkyl residue, alkene residue, and alkapolyene residue may have an alkyl side chain having 1 to 4 carbon atoms, an alkylidene side chain having 1 to 4 carbon atoms or 1 to 16 halogen atoms, and when there are 2 or more side chains, the side chains may be identical to or different from each other, and R.sup.1 and R.sup.2 are each a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or salts thereof. The pyridine compounds and salts thereof exhibit a strong insecticidal and miticidal activity and are low in residuality and accumulativity and are thus useful as insecticides and miticides for the control of pests in agriculture and horticulture.

  一种杂环化合物，其分子式为##STR1##，其中X为氢原子、卤素原子、1至4个碳原子的烷基、1至4个碳原子的烷氧基、1至4个碳原子的卤代烷基或1至4个碳原子的卤代烷氧基；n为1至5，当n为2个或更多时，X可以相同也可以不同；A为连接芳基和吡啶基4位的部分含有3至8个碳原子的烷基残基或烯基残基，或含有4至8个碳原子和2至4个双键的烯丙基残基；烷基残基、烯基残基和烯丙基残基可以含有1至4个碳原子的烷基侧链、1至4个碳原子或1至16个卤素原子的亚烷基侧链，当存在2个或更多侧链时，侧链可以相同也可以不同；R1和R2各自为氢原子或含有1至6个碳原子的烷基，或其盐。这些杂环化合物及其盐类具有强烈的杀虫和杀螨活性，且残留性和积累性低，因此作为杀虫剂和杀螨剂用于农业和园艺中控制害虫非常有用。
• Nickel-catalysed para-CH activation of pyridine with switchable regioselective hydroheteroarylation of allylarenes
  作者：Wei-Chih Lee、Chien-Hung Chen、Cheng-Yuan Liu、Ming-Shiuan Yu、Yung-Huei Lin、Tiow-Gan Ong

  DOI：10.1039/c5cc07455j

  日期：——

  para-CH activation of pyridine with allylbenzene is described by Ni/Al cooperative catalysis to achieve branch and linear selectivity.

  使用Ni/Al协同催化描述了烯丙基苯与吡啶的para-CH活化，以实现支链和线性选择性。
• PYRIDINE DERIVATIVES AND INSECTICIDAL AND MITICIDAL AGENT CONTAINING SAME AS ACTIVE INGREDIENT
  申请人：IDEMITSU KOSAN COMPANY LIMITED

  公开号：EP0383950A1

  公开（公告）日：1990-08-29

  Novel pyridine derivatives represented by general formula (I) and salts thereof are disclosed. In the said formula, X represents a hydrogen atom, a halogen atom, an alkyl group containing 1 to 4 carbon atoms, an alkoxy group or a haloalkoxy group, n represents an integer of 1 to 5, A represents an alkylene or alkenylene residue containing 3 to 8 carbon atoms or an alkapolyenylene residue containing 4 to 8 carbon atoms, which may optionally have an alkyl or alkylidene side chain containing 1 to 4 carbon atoms, or 1 to 16 halogen atoms, and R' and R2 each represents a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms. Also disclosed is an insecticidal and miticidal agent containing same as active ingredient which shows strong insecticidal and miticidal activities with reduced per- sistance and accumulation of its effect. and which can be effectively utilized for controlling harmful insects in agriculture and horticulture.

  本发明公开了通式(I)代表的新型吡啶衍生物及其盐类。在上述通式中，X 代表氢原子、卤素原子、含 1 至 4 个碳原子的烷基、烷氧基或卤代烷氧基，n 代表 1 至 5 的整数，A 代表含 3 至 8 个碳原子的亚烷基或烯基残基或含 4 至 8 个碳原子的亚烷基残基，可任选具有含 1 至 4 个碳原子的烷基或亚烷基侧链，或 1 至 16 个卤素原子，R'和 R2 各代表氢原子或含 1 至 6 个碳原子的烷基。本发明还公开了一种杀虫杀螨剂，其活性成分含有相同的杀虫杀螨剂，具有很强的杀虫杀螨活性，降低了抗药性和累积效应，可有效地用于农业和园艺业中控制有害昆虫。
• Synthesis and antifungal activity of novel aza-d--homosteroids, hydroisoquinolines, pyridines and dihydropyridines
  作者：GL Patrick、OS Kinsman

  DOI：10.1016/0223-5234(96)89557-2

  日期：1996.1

  A series of novel aza-D-homosteroids and their hydroisoquinoline precursors were synthesized and tested for antifungal activity against a variety of Candida strains and also Aspergillus species. A number of 4-substituted pyridines and tetrahydropyridines were also tested. Several compounds showed a broad spectrum of modest antifungal activity and three structures were investigated further for fungicidal and in vivo activity.
• REIMANN E.; SPECKBACHER J.; LOTTER H., ARCH. PHARM., 320,(1987) N 5, 385-393
  作者：REIMANN E.、 SPECKBACHER J.、 LOTTER H.

  DOI：——

  日期：——