dimethyl 2-piperidylmaleic acid | 4606-55-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: dimethyl 2-piperidylmaleic acid
• 英文别名: piperidin-1-yl-maleic acid dimethyl ester；N-<1,2-Bis-methoxycarbonyl-vinyl>-piperidin；Dimethyl 2-piperidin-1-ylbut-2-enedioate
• CAS: 4606-55-7
• 化学式: C₁₁H₁₇NO₄
• 分子量: 227.26
• InChiKey: VEMUSDGTYJAZKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  哌啶 、 丁炔二酸二甲酯 以 四氢呋喃 为溶剂， 反应 2.0h， 以70%的产率得到dimethyl 2-piperidylmaleic acid
  参考文献：
  名称：

  ELECTROLYTIC SOLUTION, METHOD FOR PREPARING ESTER COMPOUND CONTAINED THEREIN AND LITHIUM SECONDARY CELL

  摘要：

  提供的是一种锂二次电池，具有高容量，在高温环境中使用时抑制容量退化并改善循环特性，具有长寿命。提供的锂二次电池包括一个包含正极活性材料的正极活性材料层，一个包含负极活性材料的负极活性材料层，以及用于浸泡正极和负极活性材料层的电解质溶液，其中电解质溶液至少含有一种特定酯化合物。

  公开号：

  US20180342769A1

文献信息

• Production of Quaternary α-Aminonitriles by Means of Indium-Catalyzed Three-Component Reaction of Alkynes, Amines, and Trimethylsilyl Cyanide
  作者：Yuta Hamachi、Moe Katano、Yohei Ogiwara、Norio Sakai

  DOI：10.1021/acs.orglett.6b00508

  日期：2016.4.1

  A novel synthesis of α-aminonitriles is described via an indium-catalyzed three-component coupling reaction of alkynes, amines, and trimethylsilyl cyanide (Me3SiCN). Hydroamination of alkynes with a subsequent nucleophilic addition of Me3SiCN resulted in a novel approach to quaternary α-aminonitrile derivatives.

  通过炔烃，胺和三甲基甲硅烷基氰化物（Me 3 SiCN）的铟催化三组分偶联反应描述了α-氨基腈的新型合成。炔烃的加氢胺化反应以及随后的Me 3 SiCN亲核加成反应产生了一种新颖的季铵α-氨基腈衍生物的方法。
• Dimethylbut-2-ynedioate mediated esterification of acids via sp3 C–N bond cleavage of benzylic tertiary amines
  作者：Hao Shen、Xing Lu、Ke-Zhi Jiang、Ke-Fang Yang、Yixin Lu、Zhan-Jiang Zheng、Guo-Qiao Lai、Li-Wen Xu

  DOI：10.1016/j.tet.2012.08.024

  日期：2012.10

  A straightforward synthetic transformation of tertiary amines to the esterification of equimolar amounts of acids was demonstrated in this manuscript. The present protocol can be regarded as a straightforward synthetic transformation of tertiary amines to the esterification of equimolar amounts of acid. Moreover, the reaction is fundamentally new chemistry for the sp(3) C-N bond cleavage coupled with esterification. The esterification reaction conditions are very mild and functional group-tolerated, such as hydrosilanes, alcohols, phenol, and amino acids. A mechanism is proposed in which the tertiary amine reacts with dimethyl but-2-ynedioate to form zwitterionic salt, and then the zwitterionic intermediate subsequently accept hydrogen to assist the nucleophilic attack of oxygen atom of carboxyl group at the benzyl group of tertiary amine, while a separate reaction pathway leads to esterification. (C) 2012 Elsevier Ltd. All rights reserved.
• ELECTROLYTIC SOLUTION, METHOD FOR PREPARING ESTER COMPOUND CONTAINED THEREIN AND LITHIUM SECONDARY CELL
  申请人：NEC Corporation

  公开号：US20180342769A1

  公开（公告）日：2018-11-29

  Provided is a lithium secondary cell which has high capacity, suppresses deterioration in capacity and improves cycle characteristics particularly when used in high-temperature environments and has long lifespan. Provided is a lithium secondary cell including a positive electrode active material layer containing a positive electrode active material, a negative electrode active material layer containing a negative electrode active material and an electrolytic solution for immersing the positive and negative electrode active material layers, wherein the electrolytic solution contains at least one certain ester compound.

  提供的是一种锂二次电池，具有高容量，在高温环境中使用时抑制容量退化并改善循环特性，具有长寿命。提供的锂二次电池包括一个包含正极活性材料的正极活性材料层，一个包含负极活性材料的负极活性材料层，以及用于浸泡正极和负极活性材料层的电解质溶液，其中电解质溶液至少含有一种特定酯化合物。