2-methyleneindoline | 91785-53-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-methyleneindoline
• 英文别名: methylene-indoline；2-Methylidene-2,3-dihydro-1H-indole；2-methylidene-1,3-dihydroindole
• CAS: 91785-53-4
• 化学式: C₉H₉N
• 分子量: 131.177
• InChiKey: FDVITFMRUUGIBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5-硝基水杨醛 生成 2-methyleneindoline
  参考文献：
  名称：

  US3950356

  摘要：

  公开号：

文献信息

• COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS
  申请人：NantBioScience, Inc.

  公开号：US20180086752A1

  公开（公告）日：2018-03-29

  Compounds and compositions are presented that inhibit K-ras, and especially mutant K-ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.

  提供了抑制K-ras，尤其是突变K-ras的化合物和组合物。某些化合物优先或甚至选择性地抑制特定形式的突变K-Ras，特别是G12D突变形式。
• Multitarget Compounds Active at a PPAR and Cannabinoid Receptor
  申请人：Desreumaux Pierre

  公开号：US20110039808A1

  公开（公告）日：2011-02-17

  There is a need for pharmaceutical compounds which have activity at, at least one of a PPAR and a cannabinoid receptor. Thus there are provided such compounds, wherein the compound comprises: a PPAR pharmacophore and a cannabinoid pharmacophore linked together by a moiety comprising a fused bicyclic ring comprising a five membered ring fused with a six membered ring or a six membered ring fused with a six membered ring; wherein the cannabinoid pharmacophore comprises the fused bicyclic ring; and the PPAR pharmacophore comprises a salicylic acid, alkoxybenzylacetic acid or a alkoxyphenylacetic acid functionality; and wherein the PPAR pharmacophore is linked to the bicyclic ring of the cannabinoid pharmacophore through a linker comprising an amine or an amide functional group.

  需要具有至少一种PPAR和大麻受体活性的药物化合物。因此提供了这样的化合物，其中该化合物包括：由包含一个五元环与一个六元环或一个六元环与一个六元环融合的融合双环环的基团连接在一起的PPAR药效团和大麻药效团；其中大麻药效团包括融合双环环；而PPAR药效团包括水杨酸、烷氧基苯乙酸或烷氧基苯乙酸官能团；PPAR药效团通过包含胺基或酰胺官能团的连接物连接到大麻药效团的双环环上。
• [EN] SPIRO-OXAZINES, INDOLINONES AND PREPARATION THEREOF<br/>[FR] SPIRO-OXAZINES, INDOLINONES ET LEUR PRÉPARATION
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2014184808A1

  公开（公告）日：2014-11-20

  The present invention relates to novel spiro-oxazine analogues of Formula-I and Indolinone compounds of Formula-II or positional isomers, or stereoisomers, or derivatives, or pharmaceutically acceptable salt thereof. Formula-I Formula-II Further the invention provides transition- metal free multicomponent reaction (MCR) process for the preparation of said compounds of Formula-I and II using aryne precursor, N-substituted isatin and N-heteroaromatic compound as the nucleophile,under mild condition leading to formation of desired complex of spiro-oxazine analogues (I) and indolinone analogues (II) in high yield and selectivity.

  本发明涉及式I的新型螺环氧化吲哚类似物和式II的吲哚酮化合物或其位置异构体、对映异构体、衍生物或药用可接受盐。进一步地，本发明提供了一种无需过渡金属的多组分反应（MCR）过程，用于在温和条件下使用芳炔前体、N-取代异色满和N-杂芳族化合物作为亲核试剂来制备式I和II的化合物，从而高收率和选择性地形成所需的螺环氧化吲哚类似物（I）和吲哚酮类似物（II）的复杂结构。
• VHR PROTEIN TYROSINE PHOSPHATASE INHIBITORS, COMPOSITIONS AND METHODS OF USE
  申请人：Mustelin Tomas

  公开号：US20090105254A1

  公开（公告）日：2009-04-23

  Disclosed herein are Vaccinia H1-related (VHR) protein tyrosine phosphatase (PTP) inhibitors that provide a method for treating cancer.

  本文披露了一种可用于治疗癌症的天花H1相关（VHR）蛋白酪氨酸磷酸酶（PTP）抑制剂。
• METHOD FOR PRODUCING A PIGMENT
  申请人：Nakahama Kazumichi

  公开号：US20080182984A1

  公开（公告）日：2008-07-31

  Provided is a method for producing a pigment, in particular, a metal phthalocyanine, in high yield and in a green process. The method has (1) a step of obtaining a solution mixture by mixing at least one type of compound serving as a raw material for a pigment with a solvent, and (2) a step of obtaining the pigment by reacting the compound while holding the solution mixture at not less than a temperature where a subcritical state or a supercritical state of the solvent occurs.

  提供了一种高产且绿色的生产颜料的方法，特别是金属菲托氰颜料的方法。该方法包括(1)通过将至少一种化合物与溶剂混合得到溶液混合物的步骤，以及(2)在保持溶液混合物处于亚临界态或超临界态的温度不低于时反应该化合物以得到颜料的步骤。