4-bromo-4’-methoxy-2-nitrobiphenyl | 56985-72-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-bromo-4’-methoxy-2-nitrobiphenyl
• 英文别名: 4-bromo-4'-methoxy-2-nitro-1,1'-biphenyl；4-Bromo-4'-methoxy-2-nitrobiphenyl；4-bromo-1-(4-methoxyphenyl)-2-nitrobenzene
• CAS: 56985-72-9
• 化学式: C₁₃H₁₀BrNO₃
• 分子量: 308.131
• InChiKey: CBPHEEDMWCDONB-UHFFFAOYSA-N

物化性质

• 沸点：
  396.6±32.0 °C(Predicted)
• 密度：
  1.490±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-bromo-4’-methoxy-2-nitrobiphenyl 在 sodium hydride 、 亚磷酸三乙酯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 11.5h， 生成 2-bromo-7-methoxy-9-methylcarbazole
  参考文献：
  名称：

  Anti-Pneumocystis carinii pneumonia activity of dicationic carbazoles

  摘要：

  A series of 2,7- and 3,6-bis cationic carbazoles was synthesized and evaluated for activity against a rat model of Pneumocystis carinii pneumonia (PCP). The compounds were also tested for inhibition of topoisomerase II and binding to DNA. Several of the compounds proved to be more potent and less toxic than a standard anti-PCP drug (pentamidine). While no quantitative correlation was seen between anti-PCP activity, topoisomerase inhibition and DNA binding, a minimal level of DNA binding was found to be necessary for antimicrobial activity.

  DOI：

  10.1016/s0223-5234(99)80064-6
• 作为产物：
  描述：

  4-碘苯甲醚 、 2,5-二溴硝基苯 以to give 4-bromo-4'-methoxy-2-nitrobiphenyl, m.p. 130°-131°C的产率得到4-bromo-4’-methoxy-2-nitrobiphenyl
  参考文献：
  名称：

  Preparation of arylalkanoic acids

  摘要：

  描述了一种制备芳基丙酸的新工艺。它包括将从芳基溴化物和镁得到的格氏试剂化合物与2-溴丙酸的锂盐、钠盐、镁盐或钙盐反应，然后酸化。

  公开号：

  US03959364A1

文献信息

• A general synthesis of arylindoles and (1-arylvinyl)carbazoles via a one-pot reaction from N-tosylhydrazones and 2-nitro-haloarenes and their potential application to colon cancer
  作者：Tourin Bzeih、Timothée Naret、Ali Hachem、Nada Jaber、Ali Khalaf、Jerome Bignon、Jean-Daniel Brion、Mouad Alami、Abdallah Hamze

  DOI：10.1039/c6cc07666a

  日期：——

  A synthesis of aryl-indoles, and carbazoles from a one-pot sequence involving the coupling of hydrazones with nitro-haloarenes has been developed.

  已开发了一种从酰肼与硝基卤代芳烃偶联的一锅法序列中合成芳基吲哚和咔唑。
• A convenient and efficient one pot synthesis of unsymmetrically substituted p-terphenyls via a phosphine-free double Suzuki cross-coupling protocol using 1,4-dibromo-2-nitrobenzene as the substrate
  作者：Shahid A. Kazi、Eva M. Campi、Milton T.W. Hearn

  DOI：10.1016/j.tet.2018.01.031

  日期：2018.4

  directly to the second coupling step, in situ, using preferred aryl-boronic acids to give by this one-pot batch procedure unsymmetrically substituted para-terphenyls in excellent overall isolated yields. This methodology should be particularly suited for the generation of targeted chemical libraries, as well as for the synthesis of precursors of biologically active compounds or natural products which are

  已经开发出合成方法以使得1，4-二溴-2-硝基苯与多种芳基硼酸的顺序区域选择性的Suzuki-Miyaura交叉偶联。第一Suzuki偶联步骤，使用在室温下为游离的膦-钯催化剂，给选择性耦合在该位置的邻位的硝基，打开一个方便的合成路线，以非对称的第-terphenyls。所述bromobiaryl产物然后直接进行第二偶合步骤，在原位，使用优选的芳基硼酸通过此一锅煮批处理过程不对称取代的，得到对位-三苯并以优异的整体分离产率。该方法应特别适合于生成目标化学文库，以及合成源自不对称对-三联苯核的生物活性化合物或天然产物的前体。
• TWI523841
  申请人：——

  公开号：——

  公开（公告）日：——
• Vanadium-Catalyzed Regioselective Oxidative Coupling of 2-Hydroxycarbazoles
  作者：Lei Liu、Patrick J. Carroll、Marisa C. Kozlowski

  DOI：10.1021/ol503521b

  日期：2015.2.6

  The first regioselective oxidative coupling of 2-hydroxycarbazoles is described. With a vanadium catalyst and oxygen as the terminal oxidant, dimers with an ortho-ortho' coupling pattern were obtained with high selectivity. Further oxidation led to ortho'-ortho' coupling to generate a tetramer, which provided insight that the atropisomerization barriers of the unsymmetrical biaryl bonds are much lower than expected.
• PHOTOELECTRIC CONVERSION ELEMENT, PRODUCTION METHOD THEREOF, PHOTOSENSOR, IMAGING DEVICE AND THEIR DRIVING METHOD
  申请人：Fukuzaki Eiji

  公开号：US20120080585A1

  公开（公告）日：2012-04-05

  To provide a photoelectric conversion element capable of functioning as a photoelectric conversion element when a compound having a specific structure is applied to the photoelectric conversion element, causing the element to exhibit a low dark current, and reducing the range of increase in the dark current even when the element is heat-treated, and an imaging device equipped with such a photoelectric conversion element. A photoelectric conversion element having a photoelectric conversion film which is sandwiched between a transparent electrically conductive film and an electrically conductive film and contains a photoelectric conversion layer and an electron blocking layer, wherein the electron blocking layer contains a compound having, as a substituent, a substituted amino group containing three or more ring structures.