4-hydroxybenzoic acid N'-(3-hydroxybenzoyl)-hydrazide | 1226810-18-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-hydroxybenzoic acid N'-(3-hydroxybenzoyl)-hydrazide
• 英文别名: 3-hydroxy-N'-(4-hydroxybenzoyl)benzohydrazide
• CAS: 1226810-18-9
• 化学式: C₁₄H₁₂N₂O₄
• 分子量: 272.26
• InChiKey: LIZQIUMRQVTZIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  98.7
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-hydroxybenzoic acid N'-(3-hydroxybenzoyl)-hydrazide 在 吡啶 、 氯化亚砜 作用下， 反应 5.0h， 以550 mg的产率得到3-(5-(4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)phenol
  参考文献：
  名称：

  Stilbene analogs as inducers of apolipoprotein-I transcription

  摘要：

  Based on the naturally occurring stilbene, Resveratrol, a series of novel stilbene derivatives were synthesized, which have the ability to induce the expression of the ApoA-I gene. Several compounds equally or more potent than Resveratrol were identified. trans-4,4'-Dihydroxy-2-methoxystilbene was the most potent (4.6x more potent than Resveratrol). These compounds provide an early lead into new drugs to treat atherosclerosis. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.12.076
• 作为产物：
  描述：

  4-羟基苯甲酰肼 、 间羟基苯甲酸 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 4-hydroxybenzoic acid N'-(3-hydroxybenzoyl)-hydrazide
  参考文献：
  名称：

  Stilbene analogs as inducers of apolipoprotein-I transcription

  摘要：

  Based on the naturally occurring stilbene, Resveratrol, a series of novel stilbene derivatives were synthesized, which have the ability to induce the expression of the ApoA-I gene. Several compounds equally or more potent than Resveratrol were identified. trans-4,4'-Dihydroxy-2-methoxystilbene was the most potent (4.6x more potent than Resveratrol). These compounds provide an early lead into new drugs to treat atherosclerosis. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.12.076

文献信息

• Stilbene analogs as inducers of apolipoprotein-I transcription
  作者：Henrik C. Hansen、Fabrizio S. Chiacchia、Reena Patel、Norman C.W. Wong、Vladimir Khlebnikov、Renata Jankowska、Kalpesh Patel、M. Madhava Reddy

  DOI：10.1016/j.ejmech.2009.12.076

  日期：2010.5

  Based on the naturally occurring stilbene, Resveratrol, a series of novel stilbene derivatives were synthesized, which have the ability to induce the expression of the ApoA-I gene. Several compounds equally or more potent than Resveratrol were identified. trans-4,4'-Dihydroxy-2-methoxystilbene was the most potent (4.6x more potent than Resveratrol). These compounds provide an early lead into new drugs to treat atherosclerosis. (C) 2010 Elsevier Masson SAS. All rights reserved.