3-(Phenoxymethyl)-2-oxaspiro[4.5]decan-1-one | 62668-46-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(Phenoxymethyl)-2-oxaspiro[4.5]decan-1-one
• CAS: 62668-46-6
• 化学式: C₁₆H₂₀O₃
• 分子量: 260.333
• InChiKey: VRKSFTLYWLVTEQ-UHFFFAOYSA-N

物化性质

• 熔点：
  82 °C
• 沸点：
  155 °C(Press: 3 Torr)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-methoxy-1-trimethylsilyloxymethylenecyclohexane 、 苯基缩水甘油醚 在 四丁基氟化铵 作用下， 以 neat (no solvent) 为溶剂， 反应 2.0h， 以88%的产率得到3-(Phenoxymethyl)-2-oxaspiro[4.5]decan-1-one
  参考文献：
  名称：

  A Catalytic Approach to the Metal-Free Reaction of Epoxides with Ketene Silyl Acetals for Accessing γ-Lactones

  摘要：

  The first catalytic approach to the nucleophilic addition of silyl ketene acetals 2 to epoxides 1 is reported. The defined protocol is metal-free using tetrabutylammonioum fluoride as the catalyst. It works in a very efficient manner under solvent-free conditions (SolFC) allowing ?-lactones 3 to be directly obtained with high regioselectivities and yields.

  DOI：

  10.1021/ol502855q

文献信息

• A Catalytic Approach to the Metal-Free Reaction of Epoxides with Ketene Silyl Acetals for Accessing γ-Lactones
  作者：Simona Bonollo、Amanollah Zarei Ahmady、Chiara Petrucci、Assunta Marrocchi、Ferdinando Pizzo、Luigi Vaccaro

  DOI：10.1021/ol502855q

  日期：2014.11.7

  The first catalytic approach to the nucleophilic addition of silyl ketene acetals 2 to epoxides 1 is reported. The defined protocol is metal-free using tetrabutylammonioum fluoride as the catalyst. It works in a very efficient manner under solvent-free conditions (SolFC) allowing ?-lactones 3 to be directly obtained with high regioselectivities and yields.