bis(4-methylbenzoyloxy)methane | 111008-64-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis(4-methylbenzoyloxy)methane
• 英文别名: (4-Methylbenzoyl)oxymethyl 4-methylbenzoate
• CAS: 111008-64-1
• 化学式: C₁₇H₁₆O₄
• 分子量: 284.312
• InChiKey: CUDNQXJBJLCQQC-UHFFFAOYSA-N

物化性质

• 熔点：
  98-100 °C
• 沸点：
  441.5±33.0 °C(Predicted)
• 密度：
  1.174±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二溴甲烷 生成 bis(4-methylbenzoyloxy)methane
  参考文献：
  名称：

  SALUNKHE D. G.; JAGDALE M. H.; SALUNKHE M. M.; WADGAONKAR P. P., BULL. SOC. CHIM. BELG., 96,(1987) N 3, 247-248

  摘要：

  DOI：

文献信息

• Synthesis of esters from aldehydes or carboxylic acids with dichloromethane, dichloroethane or dichloropropane under mild conditions
  作者：Feng Lin、Qiang Feng、Xiuling Cui、Qiuling Song

  DOI：10.1039/c3ra43615b

  日期：——

  Dichloromethane (DCM) as a C1 source has been discovered: methylene diesters from DCM and carboxylic acids or aldehydes with TBHP in water were efficiently synthesized. The reactions proceed under mild conditions and afford both aliphatic and aromatic methylene diesters in good to excellent yields (up to >99%). 2-Chloroethyl benzoates and 3-chloropropyl benzoates are easily obtained in the same way from 1,2-dichloroethane and 1,3-dichloropropane, respectively, in good to excellent yields.

  二氯甲烷（DCM）作为C1来源的新发现：DCM与羧酸或醛在TBHP水溶液中高效合成了亚甲基双酯。这些反应在温和条件下进行，能够以优异至极佳的产率（高达>99%）得到脂肪族和芳香族亚甲基双酯。同样的方法，可以从1,2-二氯乙烷和1,3-二氯丙烷分别容易地获得良好的至极佳产率的2-氯乙基苯甲酸酯和3-氯丙基苯甲酸酯。
• Solvent-free synthesis of symmetric methylene diesters <i>via</i> direct reaction of aromatic carboxylates with 1,<i>n</i>-dihaloalkanes
  作者：Lin Bai、Shenglong Ding、Xiaofang Ma

  DOI：10.1039/d1ra04814g

  日期：——

  An efficient methodology for the synthesis of symmetrical methylene diesters was developed through direct reaction of various aromatic carboxylates with 1,n-dihaloalkanes under solvent-free conditions. This strategy offers a high product yield, facile work-up and purification, and an environmentally friendly approach to obtain long-chain methylene carboxylate scaffolds with increased diversity.

  通过各种芳族羧酸盐与 1, n-二卤代烷烃在无溶剂条件下的直接反应，开发了一种合成对称亚甲基二酯的有效方法。该策略提供了高产率、简便的后处理和纯化，以及一种环境友好的方法来获得具有增加多样性的长链羧酸亚甲酯支架。
• DBU-CH₃I, a Potential Substitute for CH₂N₂ in the Preparation of Methyl Esters and Methyl Aryl Ethers: Studies with Assorted Acids
  作者：Dipakranjan Mal、Amit Jana、Sutapa Ray、Sourav Bhattacharya、Asit Patra、Saroj R. De

  DOI：10.1080/00397910802238809

  日期：2008.10.28

  Abstract DBU-CH3I has been poised to be a substitute for diazomethane in the preparation of methyl esters from carboxylic acids. The reactions can be carried out in commercial untreated acetone and acetonitrile, which have been exemplified with several methyl esters, otherwise it is difficult to prepare. Bis-esterification using diiodomethane can also be achieved in a similar fashion. Sufficiently

  摘要 DBU-CH3I 已准备好在由羧酸制备甲酯中替代重氮甲烷。反应可以在商业未处理的丙酮和乙腈中进行，已经以几种甲酯为例，否则很难制备。使用二碘甲烷的双酯化也可以类似方式实现。足够酸性的酚也可以方便地通过该方法O-甲基化。
• Palladium(II)-Catalyzed<i>ortho</i>Alkylation of Benzoic Acids with Alkyl Halides
  作者：Yang-Hui Zhang、Bing-Feng Shi、Jin-Quan Yu

  DOI：10.1002/anie.200902262

  日期：2009.8.3

  Outsmarting the competition: In the PdII‐catalyzed reaction of benzoates with alkyl halides, an aryl CH bond is activated before the competitive alkylation of the carboxylate anion can takes place. The alkylation reaction was followed by an intramolecular lactonization to give broadly useful γ‐ and δ‐benzolactones (see scheme).

  战胜竞争：在 Pd II催化的苯甲酸盐与卤代烷的反应中，芳基 C  H 键在羧酸根阴离子的竞争性烷基化发生之前被激活。烷基化反应后进行分子内内酯化，得到广泛有用的 γ- 和 δ-苯内酯（参见方案）。
• Novel Monensin Derivatives for the Treatment and Prevention of Protozoal Infections
  申请人：Delaveau Jean

  公开号：US20120128722A1

  公开（公告）日：2012-05-24

  This invention relates to novel polyether ionophores, formulations comprising same, and to methods of making and using these compounds and formulations for the treatment and/or prevention of parasitic infection in animals and humans. These compounds exhibit improved safety profiles and/or efficacies as compared to parent compounds.

  本发明涉及新型聚醚离子载体，包括该载体的制剂，以及使用这些化合物和制剂治疗和/或预防动物和人类的寄生虫感染的方法。这些化合物与母体化合物相比，展现出改进的安全性和/或疗效。