2-acetamido-1-aminopropane | 36506-51-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-acetamido-1-aminopropane
• 英文别名: 2-acetamidopropylamine；acetylpropylenediamine；2-Acetylaminopropylamine；N-(1-aminopropan-2-yl)acetamide
• CAS: 36506-51-1
• 化学式: C₅H₁₂N₂O
• 分子量: 116.163
• InChiKey: IGIJDAVPCAUGCU-UHFFFAOYSA-N

物化性质

• 沸点：
  278.1±23.0 °C(Predicted)
• 密度：
  0.959±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  异喹啉-5-磺酰氯 、 2-acetamido-1-aminopropane 在 三乙胺 作用下， 以 氯仿 为溶剂， 以83%的产率得到N-(2-acetylaminopropyl)-5-isoquinolinesulfonamide
  参考文献：
  名称：

  Isoquinolinesulfonyl derivatives and process for the preparation thereof

  摘要：

  一种Formula (I)的5-异喹啉磺酰衍生物：其中l为零或一；m和n均为1至9的整数；m+n至少为一个整数；R.sub.1为氢原子，C.sub.1-10烷基，C.sub.5-6环烷基或芳基；或R.sub.2和R.sub.3各自为氢原子，C.sub.1-10烷基，C.sub.5-6环烷基，芳基或芳基烷基；R.sub.2和R.sub.3为C.sub.1-6烷基基团，并直接或通过氧原子连接形成与相邻氮原子共轭的5-至7-成员杂环环；或##STR2##基团为##STR3##基团，其中R.sub.4和R.sub.5各自为氢原子，C.sub.1-10烷基，芳基或芳基烷基，R.sub.6为氢原子，C.sub.1-10烷基，芳基，芳基烷基，苯甲酰基，肉桂基，肉桂酰基，呋喃基或##STR4##基团，其中R.sub.7为C.sub.1-8烷基；以及其药学上可接受的盐；以及其制备方法。该发明的化合物对血管平滑肌具有松弛作用，并可用作血管扩张剂和降压剂。

  公开号：

  US04456757A1
• 作为产物：
  描述：

  异丙醇胺 、 乙腈 在 硫酸 、 溶剂黄146 作用下， 反应 5.0h， 以30%的产率得到2-acetamido-1-aminopropane
  参考文献：
  名称：

  Synthesis of 3-hydroxypyrid-2-ones from furfural for treatment against iron overload and iron deficiency

  摘要：

  Derivatives of 3-hydroxypyrid-2-ones, which posses very high affinity for iron and have anomalous applications in iron overload and iron deficiency, were prepared from furfural in simple reaction conditions. (C) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.11.013

文献信息

• Metal-Free <i>O</i> -Selective Direct Acylation of Amino Alcohols Through Pseudo-Intramolecular Process
  作者：Soichi Yokoyama、Hiroshi Shibauchi、Haruyasu Asahara、Nagatoshi Nishiwaki

  DOI：10.1002/ejoc.201801589

  日期：2019.2.7

  Acylation of diamines using α‐aryl‐β‐keto esters occurs regioselectively at the less hindered amino group. The transacylation using N‐alkylamino alcohol resulted in chemoselective O‐acylation in the absence of metal catalyst. Protection of the amino group is not necessary. These reactions proceed efficiently because of the pseudo‐intramolecular process.

  使用α-芳基-β-酮酸酯对二胺进行酰化反应会在较低受阻氨基上区域选择性地发生。在没有金属催化剂的情况下，使用N-烷基氨基醇进行的酰基转移反应会导致化学选择性的O-酰基化反应。不需要保护氨基。由于拟分子内过程，这些反应有效地进行。
• Guanidine accelerators for peroxide hair bleaching compositions
  申请人：Henkel Kommanditgesellschaft auf Aktien (Henkel KGaA)

  公开号：US04186186A1

  公开（公告）日：1980-01-29

  A composition for bleaching hair comprising a peroxide oxidation agent, an ammonia-free alkalinization agent and a guanidine derivative of the formula ##STR1## as bleaching accelerator, wherein R is hydrogen, ##STR2## Y is hydrogen, NH.sub.2, or alkyl having 1 to 4 carbon atoms, and n is 2 or 3, or an acid addition salt thereof.

  一种漂白头发的组合物，包括过氧化物氧化剂、无氨碱化剂和一种式为##STR1##的胍嘧啶衍生物作为漂白催化剂，其中R为氢，##STR2## Y为氢、NH.sub.2或具有1至4个碳原子的烷基，n为2或3，或其酸加盐。
• Isoquinolinesulfonamide derivatives
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：US04634770A1

  公开（公告）日：1987-01-06

  This invention relates to novel isoquinolinesulfonamide derivatives of Formula (I): ##STR1## wherein A is a C.sub.0-10 alkylene group or a C.sub.0-10 alkylene group having a C.sub.1-10 alkyl group, a phenyl group, a substituted phenyl group or a phenylalkyl group; R.sub.1 and R.sub.2 each is a hydrogen atom; or R.sub.1 and R.sub.2 are linked directly to form an ethylene group unsubstituted or substituted with a C.sub.1-4 alkyl group; R.sub.3 and R.sub.4 each is a hydrogen atom, a C.sub.1-6 alkyl group or linked directly to form a C.sub.2-6 alkylene group; and the pharmaceutically acceptable acid addition salt thereof, and to a process for preparing them. The isoquinoline derivatives possess a relaxatory action for vascular smooth muscle and action for increasing blood flow and are useful as a vasodilator and a hypotensor.

  本发明涉及一种新型异喹啉磺酰胺衍生物，其化学式为（I）：##STR1## 其中A是C.sub.0-10烷基或C.sub.0-10烷基，具有C.sub.1-10烷基，苯基，取代苯基或苯基烷基；R.sub.1和R.sub.2各为氢原子；或R.sub.1和R.sub.2直接连接形成未取代或取代有C.sub.1-4烷基的乙烯基；R.sub.3和R.sub.4各为氢原子，C.sub.1-6烷基或直接连接形成C.sub.2-6烷基；以及其药学上可接受的酸加盐，以及制备它们的方法。异喹啉衍生物具有舒张血管平滑肌和增加血流的作用，可用作扩血管剂和降压剂。
• Isoquinolinesulfonyl derivatives
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：US04525589A1

  公开（公告）日：1985-06-25

  A 5-isoquinolinesulfonyl derivative of Formula (I): ##STR1## wherein l is zero or one; m and n each is an integer of one to nine; m+n is an integer of at least one R.sub.1 is a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.5-6 cycloalkyl group or an aryl group; or R.sub.2 and R.sub.3 each is a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.5-6 cycloalkyl group, an aryl group or an aralkyl group; R.sub.2 and R.sub.3 are C.sub.1-6 alkylene groups and linked directly or through an oxygen atom to form a 5- to 7-membered heterocyclic ring with the adjacent nitrogen atom; or the ##STR2## group is a ##STR3## group wherein R.sub.4 and R.sub.5 each is a hydrogen atom, a C.sub.1-10 alkyl group, an aryl group or an aralkyl group and R.sub.6 is a hydrogen atom, a C.sub.1-10 alkyl group, an aryl group, an aralkyl group, a benzoyl group, a cinnamyl group, a cinnamoyl group, a furoyl group or a ##STR4## group wherein R.sub.7 is a C.sub.1-8 alkyl group; and the pharmaceutically acceptable salt thereof; and a process for the preparation thereof. The compounds of this invention have a relaxatory action for vascular smooth muscle and are useful as a vasodilator and a hypotensor.

  公式（I）的5-异喹啉磺酰衍生物：##STR1## 其中l为零或一；m和n均为1至9的整数；m+n至少为1的整数；R.sub.1为氢原子，C.sub.1-10烷基，C.sub.5-6环烷基或芳基；或R.sub.2和R.sub.3均为氢原子，C.sub.1-10烷基，C.sub.5-6环烷基，芳基或芳基烷基；R.sub.2和R.sub.3是C.sub.1-6烷基，直接或通过氧原子与相邻的氮原子形成5-至7-成员杂环环；或##STR2##基团是##STR3##基团，其中R.sub.4和R.sub.5均为氢原子，C.sub.1-10烷基，芳基或芳基烷基，R.sub.6为氢原子，C.sub.1-10烷基，芳基，芳基烷基，苯甲酰基，肉桂基，肉桂酰基，呋喃基或##STR4##基团，其中R.sub.7为C.sub.1-8烷基；以及其药学上可接受的盐；以及其制备过程。该发明化合物对血管平滑肌具有松弛作用，可用作扩血管剂和降压剂。
• Isoquinolinesulfonyl derivatives which possess a relaxatory action
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：US04560755A1

  公开（公告）日：1985-12-24

  A 5-isoquinolinesulfonyl derivative of Formula (I): ##STR1## wherein l is zero or one; m and n each is an integer of one to nine; m+n is an integer of at least one; R.sub.1 is a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.5-6 cycloalkyl group or an aryl group; or R.sub.2 and R.sub.3 each is a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.5-6 cycloalkyl group, an aryl group or an aralkyl group; R.sub.2 and R.sub.3 are C.sub.1-6 alkylene groups and linked directly or through an oxygen atom to form a 5- to 7-membered heterocyclic ring with the adjacent nitrogen atom; or the ##STR2## wherein R.sub.4 and R.sub.5 each is a hydrogen atom, a C.sub.1-10 alkyl group, an aryl group or an aralkyl group and R.sub.6 is a hydrogen atom, a C.sub.1-10 alkyl group, an aryl group, an aralkyl group, a benzoyl group, a cinnamyl group, a cinnamoyl group, a furoyl group or a ##STR3## wherein R.sub.7 is a C.sub.1-8 alkyl group; and the pharmaceutically acceptable salt thereof; and a process for the preparation thereof. The compounds of this invention have a relaxatory action for vascular smooth muscle and are useful as a vasodilator and a hypotensor.

  公式（I）的5-异喹啉磺酰衍生物：##STR1## 其中l为零或一；m和n各为1到9的整数；m+n至少为1的整数；R1为氢原子，C1-10烷基，C5-6环烷基或芳基；或R2和R3各为氢原子，C1-10烷基，C5-6环烷基，芳基或芳基烷基；R2和R3为C1-6烷基，直接或通过氧原子与相邻的氮原子连接，形成5-至7-成员的杂环环与；或##STR2## 其中R4和R5各为氢原子，C1-10烷基，芳基或芳基烷基，R6为氢原子，C1-10烷基，芳基，芳基烷基，苯甲酰基，肉桂基，肉桂酰基，呋喃基或##STR3## 其中R7为C1-8烷基；以及其药学上可接受的盐；以及其制备过程。本发明的化合物具有血管平滑肌松弛作用，可用作血管扩张剂和降压剂。