epoxy-5,6 hexanoate de methyle | 87321-81-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: epoxy-5,6 hexanoate de methyle
• 英文别名: 4,5-epoxypentane carboxylic acid methyl ester；(-)-methyl 5,6-epoxyhexanoate；Methyl 4-(oxiran-2-YL)butanoate
• CAS: 87321-81-1
• 化学式: C₇H₁₂O₃
• 分子量: 144.17
• InChiKey: IFAJEWATDTUSCV-UHFFFAOYSA-N

物化性质

• 沸点：
  103 °C(Press: 30 Torr)
• 密度：
  1.069±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-已酸甲酯 生成 epoxy-5,6 hexanoate de methyle
  参考文献：
  名称：

  Deplacements homolytiques intramoleculaires : V - epoxy-2,3 propanation des acides et derives par thermolyse du peroxyde d'allyle et de t-butyle

  摘要：

  DOI：

  10.1016/s0040-4020(01)96373-2

文献信息

• Optically active 2,2-dimethyl-1,3-dioxin-4-ones and method for preparing
  申请人：Chisso Corporation

  公开号：US05292891A1

  公开（公告）日：1994-03-08

  There are provided novel and optically active 2,2-dimethyl-1,3-dioxin-4-ones which are useful as starting materials for physiologically active compounds, functional materials or the like. Provided are optically active 5,6-epoxyhexanoic acid esters and novel optically active 6-substituted tetrahydropyran-2-one derivatives. That is, optically active 6-chloromethyltetrahydropyran-2-one can be synthesized by lactonizing optically active 2,2-dimethyl-6-(3-chloro-2-hydroxypropyl)-1,3-dioxin-4-one to form optically active 6-chloromethyltetrahydropyran-2,4-dione; reacting the thus formed compound with hydrogen in the presence of a catalyst to obtain optically active 6-chloromethyl-4-hydroxytetrahydropyran-2-one; subjecting this compound to a dehydration reaction, thereby obtaining optically active 6-chloromethyldihydropyran-2-one; reacting this compound with hydrogen in the presence of a catalyst to form optically active 6-chloromethyltetrahydropyran-2-one; and then treating this compound under basic conditions to prepare an optically active 5,6-epoxyhexanoic acid ester represented by the formula (6) ##STR1## (wherein the symbol * represents an asymmetric carbon atom, and R is a methyl group or an ethyl group).

  提供了新颖且光学活性的2,2-二甲基-1,3-二氧杂环丁酮，可用作生理活性化合物、功能材料或类似物的起始材料。提供了光学活性的5,6-环氧己酸酯和新颖的光学活性6-取代四氢吡喃-2-酮衍生物。也就是说，可以通过将光学活性的2,2-二甲基-6-(3-氯-2-羟基丙基)-1,3-二氧杂环丁酮酯化生成光学活性的6-氯甲基四氢吡喃-2,4-二酮；在催化剂存在下用氢气与所形成的化合物反应，得到光学活性的6-氯甲基-4-羟基四氢吡喃-2-酮；将该化合物进行脱水反应，从而得到光学活性的6-氯甲基二氢吡喃-2-酮；在催化剂存在下用氢气与该化合物反应，形成光学活性的6-氯甲基四氢吡喃-2-酮；然后在碱性条件下处理该化合物，制备由式(6)所代表的光学活性的5,6-环氧己酸酯（其中符号*代表一个不对称碳原子，R为甲基或乙基基团）。
• Intramolecular homolytic displacements 7 — Free radical additions to unsaturated peroxy compounds : Synthesis of oxygenated heterocycles
  作者：Bernard Maillard、Abdelmajid Kharrat、Felicien Rakotomanana、Evelyne Montaudon、Christian Gardrat

  DOI：10.1016/s0040-4020(01)97183-2

  日期：1985.1

  Free radical additions of hydrogen donor solvents to tert-butyl perpent-4-enoate have given 4-substituted γ-butyrolactones, with yields of 50 % or greater. Such reactions applied to allyl-tert-butyl peroxide have produced 2,3-epoxypropanation of these solvents. Similar addition-elimination processes occurred with tert-butyl 4-methyl-perpent-4-enoate, tert-butyl 2,2-dimethyl-perpent-4-enoate and tert-butyl-methallyl

  将氢供体溶剂自由基加到过戊-4-烯酸叔丁酯中，得到4-取代的γ-丁内酯，产率为50％或更高。应用于烯丙基叔丁基过氧化物的这种反应已经产生了这些溶剂的2，3-环氧丙烷化。4-甲基-过戊-4-烯酸酯叔丁基，2,2-二甲基-过戊-4-烯酸酯叔丁基和过氧化甲基叔丁基甲基烯丙基也发生了类似的加成消除过程，但对于叔丁基5则失败了。 -甲基-己基-4-烯酸酯和叔丁基-3-甲基-丁-2-烯基过氧化物。
• Process for preparing unsaturated six-membered lactones
  申请人：Dynamit Nobel AG

  公开号：US04562270A1

  公开（公告）日：1985-12-31

  There are disclosed and claimed substituted cyclic lactones and process for preparation thereof. In particular, there are disclosed substituted cyclic lactones having alkyl substituents on the ring, especially such lactones having substituents on the ring of which two on the same carbon atom. Additionally, the invention herein disclosed and claimed relates to a process for the preparation of lactones by heating a six-membered hydroxy substituted lactone in the presence of a catalyst.

  本发明公开和声明了替代的环状内酯及其制备方法。具体地，本发明公开了在环上具有烷基取代基的替代环状内酯，特别是在同一碳原子上有两个取代基的环状内酯。此外，本发明公开和声明的发明涉及一种通过在催化剂存在下加热六元羟基取代内酯来制备内酯的方法。
• Montaudon, E.; Rakotomanana, F.; Maillard, B., Bulletin de la Societe Chimique de France, 1985, # 2, p. 198 - 202
  作者：Montaudon, E.、Rakotomanana, F.、Maillard, B.

  DOI：——

  日期：——
• MONTAUDON, E.;RAKOTOMANANA, F.;MAILLARD, B., TETRAHEDRON, 1985, 41, N 13, 2727-2735
  作者：MONTAUDON, E.、RAKOTOMANANA, F.、MAILLARD, B.

  DOI：——

  日期：——