3-(3,4-dimethoxyphenyl)propanehydrazide | 88368-71-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(3,4-dimethoxyphenyl)propanehydrazide
• CAS: 88368-71-2
• 化学式: C₁₁H₁₆N₂O₃
• mdl: MFCD16313199
• 分子量: 224.26
• InChiKey: KVWUYHRCGXMGJT-UHFFFAOYSA-N

物化性质

• 熔点：
  132-133 °C
• 沸点：
  430.7±35.0 °C(Predicted)
• 密度：
  1.141±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  73.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(3,4-dimethoxyphenyl)propanehydrazide 在 盐酸 、 sodium nitrite 作用下， 生成 β-(3.4-Dimethoxyphenyl)propionsaeure-azid
  参考文献：
  名称：

  273.合成异喹啉衍生物的实验。第三部分 钴醛的合成

  摘要：

  DOI：

  10.1039/jr9340001263
• 作为产物：
  描述：

  ethyl (E)-3,4-dimethoxycinnamate 在 乙醇 、 镍 、 一水合肼 作用下， 生成 3-(3,4-dimethoxyphenyl)propanehydrazide
  参考文献：
  名称：

  Partieller霍夫曼“谢尔Abbau德Emetins sowie围网Dehydrierung祖Emetamin

  摘要：

  DOI：

  10.1002/hlca.19440270145

文献信息

• [EN] BIOISPIRED PROTEASOME ACTIVATORS WITH ANTIAGEING ACTIVITY<br/>[FR] ACTIVATEURS BIO-INSPIRÉS DES PROTÉASOMES AYANT UNE ACTIVITÉ ANTI-ÂGE
  申请人：NATIONAL HELLENIC RES FOUNDATION

  公开号：WO2019171088A1

  公开（公告）日：2019-09-12

  The present invention relates to novel bio-inspired hybrid compounds of formula I which act as proteasome activators and exhibit anti-ageing activity, as well as methods for their synthesis. These hybrid compounds combine the structural features of hydroxytyrosol and the natural antioxidant vitamin E or its bioisosteres in one molecular scaffold. The compounds of formula I, which include structural proteasome activators (activation by stereochemical interaction), can be used in the production of anti-ageing products, such as cosmetic preparations. Additionally, they can be used in conditions and diseases where the proteasome is down-regulated, as well as proteasome-activation control compounds.

  本发明涉及新型生物启发的混合化合物，其化学式为I，作为蛋白酶体激活剂并具有抗衰老活性，以及其合成方法。这些混合化合物将羟基酪醇和天然抗氧化维生素E或其生物同系物的结构特征结合在一个分子支架中。化合物I的结构包括结构蛋白酶体激活剂（通过立体化学相互作用激活），可用于生产抗衰老产品，如化妆品制剂。此外，它们可以在蛋白酶体被下调的情况和疾病中使用，以及用作蛋白酶体激活控制化合物。
• Exploration of diphenylalkyloxadiazoles as novel cardiac myosin activator
  作者：Manoj Manickam、Pulla Reddy Boggu、Thanigaimalai Pillaiyar、Niti Sharma、Hitesh B. Jalani、Eeda Venkateswararao、Sang-Hun Jung

  DOI：10.1016/j.bmcl.2018.06.031

  日期：2018.8

  To explore novel cardiac myosin activator, a series of diphenylalkyl substituted 1,3,4-oxadiazoles and 1,2,4-oxadiazoles have been prepared and tested for cardiac myosin ATPase activation in vitro. In all cases, three carbon spacer between the oxadiazole core and one of the phenyl ring was considered crucial. In case of 1,3,4-oxadiazole, zero to two carbon spacer between oxadiazole core and other phenyl

  为了探索新型的心肌肌球蛋白活化剂，已经制备了一系列的二苯烷基取代的1,3,4-恶二唑和1,2,4-恶二唑，并在体外测试了心脏肌球蛋白ATP酶的活化。在所有情况下，在恶二唑核和苯环之一之间的三个碳间隔基被认为是至关重要的。在1,3,4-恶二唑的情况下，恶二唑核与其他苯环之间的零至两个碳间隔是有利的。苯环可以被环己基部分取代。在1,2,4-恶二唑的情况下，恶二唑与其他苯环之间的零或一个碳间隔基是有利的。在2氢键供体（NH）基团的引入第二1,3,4-恶二唑的位置增强了活性。两种恶二唑均不能耐受任何一个苯环上的取代或苯环上的取代成其他杂环。所制备的恶二唑在平滑肌和骨骼肌上显示出对心肌的选择性激活。
• Intramolecular addition of acyldiazenecarboxylates onto double bonds in the synthesis of heterocycles
  作者：José V. Prata、Dina-Telma S. Clemente、Sundaresan Prabhakar、Ana M. Lobo、Isabel Mourato (in part)、Paula S. Branco (in part)

  DOI：10.1039/b110414d

  日期：2002.2.6

  Appropriate aryl-substituted unsymmetrical azodicarbonyl compounds, generated from bishydrazides by oxidation, undergo intramolecular cyclisations to furnish a variety of useful heterocycles such as N-substituted oxindoles, carbostyrils, benzazepinones, benzazocinones, benzimidazolones, benzoxazinones and pyrazolones in varying degrees of efficiency. Methods are described to remove the N-acyl groups from the heteroaromatic compounds. Under mildly acidic conditions where equal opportunities are available for an ipso or a normal cyclisation it is the former process that occurs preferentially. Evidence is presented in favour of a C-to-C migration in the ipso product for the formation of a methoxy-substituted carbostyril derivative. One of the spiro substances is shown to participate in dienone–phenol rearrangement to provide the corresponding quinolone–phenol in high yield.

  适当的芳基取代的不对称二羧肼化合物通过氧化从双肼酰胺生成，发生分子内环化，生成各种有用的杂环化合物，如N-取代的氧杂吲哚、羧基醇、苯并氮杂哌啶、苯并氮杂呋喃、苯并咪唑酮、苯并氧杂噁唑和吡唑酮，效率各不相同。文中描述了去除杂芳香化合物中N-酰基基团的方法。在弱酸性条件下，当存在相等机会进行ipso或正常环化时，前者过程优先发生。证据支持在ipso产物中发生C到C的迁移，用于形成甲氧基取代的羧基醇衍生物。显示出某个螺旋物质参与二烯酮–酚重排，以高产率生成相应的喹啉–酚。
• Syntheses and anti-inflammatory and analgesic activities of hydroxamic acids and acid hydrazides.
  作者：KUNIYOSHI TANAKA、KEIZO MATSUO、AI NAKANISHI、TOSHIKO HATANO、HISAKO IZEKI、YOKO ISHIDA、WASUKE MORI

  DOI：10.1248/cpb.31.2810

  日期：——

  On the basis of the generally accepted view that copper ions take part in the occurrence of inflammation, hydroxamic acids and acid hydrazides derived from various substituted cinnamic acids and hydrocinnamic acids, which were expected to chelate with copper ions, were synthesized and evaluated for anti-inflammatory activity by the carrageenin-induced rat paw edema assay and for analgesic activity by the phenylquinone writhing method in mice. Some of the synthesized compounds exhibited both activities, and 3-(3, 4-dimethoxyphenyl)propiohydroxamic acid and its Zn complex were more active than aspirin. The Cu (II) complexes of hydroxamic acid derivatives were synthesized and were assumed to have polymeric structures from the results of elemental analysis, molecular weight measurement and determination of magnetic susceptibility.

  根据普遍接受的观点，铜离子参与了炎症的发生，因此合成了来自各种取代肉桂酸和氢肉桂酸的羟肟酸和酸肼，期望它们能与铜离子形成配位化合物，并通过卡拉胶诱导的大鼠爪肿胀实验评估其抗炎活性，通过苯醌扭动法评估其镇痛活性。部分合成的化合物表现出这两种活性，3-(3, 4-二甲氧基苯基)丙氢羟肟酸及其锌配合物的活性超过阿司匹林。羟肟酸衍生物的铜(II)配合物被合成，并根据元素分析、分子量测定和磁性测试结果推测其具有聚合结构。
• New process for the synthesis of the levodopa
  申请人：MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA

  公开号：EP0357565A2

  公开（公告）日：1990-03-07

  New process for the synthesis of the levodopa, L-(-)-2-amino-­3-(3,4-dihydroxyphenyl)propionic acid, drug used in the treatment of the Parkinson's disease. The process consists in resolving with d-camphorsulfonic acid, or with a salt thereof,the d,l-2-amino-3-(3,4-dimethoxyphenyl)propionitrile, obtained from the 3,4-dimethoxyphenylacetaldehyde, and in the subsequent hydrolysis and methylation, by means of concentrated solutions of haloid acids, of the d-2-amino-3-­(3,4-dimethoxyphenyl)propionitrile and of salts thereof.

  合成左旋多巴（L-(-)-2-氨基-3-(3,4-二羟基苯基)丙酸）的新工艺，用于治疗帕金森病。该工艺包括用 d-樟脑磺酸或其盐溶解从 3,4-二甲氧基苯乙醛中得到的 d,l-2-氨基-3-(3,4-二甲氧基苯基)丙腈，然后用卤酸的浓溶液对 d-2-氨基-3-(3,4-二甲氧基苯基)丙腈及其盐进行水解和甲基化。