3-Phenyl-2-(undec-10-enamido)propanoic acid | 420805-16-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-Phenyl-2-(undec-10-enamido)propanoic acid
• 英文别名: 3-phenyl-2-(undec-10-enoylamino)propanoic acid
• CAS: 420805-16-9
• 化学式: C₂₀H₂₉NO₃
• 分子量: 331.4
• InChiKey: RTBWWWVNZWFNBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  24
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• COMBINATIONS OF ALKYLAMIDOTHIAZOLES AND PRESERVATIVES
  申请人：BEIERSDORF AG

  公开号：US20160015615A1

  公开（公告）日：2016-01-21

  Disclosed are active ingredient combinations of alkylamidothiazoles and one or more cosmetically or dermatologically acceptable preservatives.

  揭示了烷基氨基噻唑和一种或多种在化妆品或皮肤科学上可接受的防腐剂的活性成分组合。
• COMPOSITIONS OF ALKYLAMIDOTHIAZOLES AND FRAGRANCES
  申请人：BEIERSDORF AG

  公开号：US20160015613A1

  公开（公告）日：2016-01-21

  Disclosed are active ingredient combinations of alkylamidothiazoles and one or more cosmetically or dermatologically relevant fragrances.

  揭示了烷基酰胺噻唑酮和一种或多种在化妆品或皮肤科学方面相关的香料的活性成分组合。
• COMPOSITIONS OF ALKYLAMIDOTHIAZOLES AND UV-FILTER SUBSTANCES
  申请人：BEIERSDORF AG

  公开号：US20160015614A1

  公开（公告）日：2016-01-21

  Disclosed are active ingredient combinations of alkylamidothiazoles and one or more cosmetically or dermatologically acceptable UV-filter substances.

  揭示了烷基氨基噻唑和一种或多种化妆或皮肤学上可接受的紫外线过滤物质的活性成分组合。
• COMPOUNDS FOR PREVENTING, REDUCING AND/OR ALLEVIATING ITCHY SKIN CONDITION(S)
  申请人：SCHMAUS Gerhard

  公开号：US20160008297A1

  公开（公告）日：2016-01-14

  The present invention primarily relates to the use of one or more specific compounds and/or one or more respective salt(s) thereof for preventing, reducing or alleviating itchy skin condition(s), and/or as PAR-2 antagonist. Furthermore, the present invention relates to compositions (products or, respectively, formulations), in particular for topical administration, preferably cosmetic or pharmaceutical compositions, in particular for preventing, reducing or alleviating one or more itchy skin conditions and/or for providing a PAR-2 antagonistic effect, comprising or consisting of an effect amount of such compound(s) and/or salt(s) and one or more cosmetically and/or pharmaceutically acceptable carriers.

  本发明主要涉及使用一种或多种特定化合物和/或其一个或多个相应盐来预防、减少或缓解瘙痒皮肤状况，和/或作为PAR-2拮抗剂。此外，本发明涉及组合物（产品或相应的配方），特别是用于局部给药，优选为化妆品或药用组合物，特别是用于预防、减少或缓解一种或多种瘙痒皮肤状况和/或产生PAR-2拮抗作用的组合物，包括或由效果量的这种化合物和/或盐以及一个或多个化妆品和/或药用可接受载体组成。
• NOVEL DERIVATIVES OF SINAPINIC ACID AND THE COSMETIC OR PHARMACEUTICAL USES THEREOF
  申请人：BASF Beauty Care Solutions France SAS

  公开号：US20150342847A1

  公开（公告）日：2015-12-03

  The present invention relates to a compound of general formula (I) below: in which: R 1 , R 2 and R 3 independently of one another represent a hydrogen atom; a C1-12 alkyl group; a C2-12 alkenyl group; a C2-12 alkynyl group; a C3-12 cycloalkyl group; a C1-12 acyl group; a sulfonyl group or a phosphonate group; represents a CH 2 —CH 2 group or a CH═CH group; n is an integer between 1 and 3; or a salt thereof. The invention further relates to a process for synthesizing this compound or salt, to a composition comprising it, to its cosmetic use, more particularly as a depigmenting agent and/or as a radical scavenger, to a cosmetic care process, and to its use as a drug, advantageously intended for preventing and/or treating pathological hyperpigmentation and/or inflammation.

  本发明涉及以下一般式（I）的化合物： 其中： R1、R2和R3分别独立地表示氢原子；C1-12烷基基团；C2-12烯基基团；C2-12炔基基团；C3-12环烷基基团；C1-12酰基团；磺酰基或膦酸酯基团；表示CH2—CH2基团或CH═CH基团；n是1到3之间的整数；或其盐。该发明还涉及合成该化合物或盐的过程，包括它的组合物，其化妆品用途，尤其作为脱色剂和/或自由基清除剂，化妆保养过程，以及其作为药物的用途，有利于预防和/或治疗病理性色素沉着和/或炎症。