1-(1-(4-bromophenyl)-4-(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)ethanone | 1432986-12-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-(1-(4-bromophenyl)-4-(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)ethanone
• 英文别名: 1-[1-(4-Bromophenyl)-4-(4-chlorophenyl)-2-methyl-1h-pyrrol-3-yl]ethan-1-one；1-[1-(4-bromophenyl)-4-(4-chlorophenyl)-2-methylpyrrol-3-yl]ethanone
• CAS: 1432986-12-3
• 化学式: C₁₉H₁₅BrClNO
• 分子量: 388.691
• InChiKey: ZJVAPZYEQDPNLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  22
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-(4-氯苯基)-2-硝基乙烯 、 乙酰丙酮 、 4-溴苯胺 在 3-methyl-2-(1-sulfobutyl)-1H-imidazolium hydrogen sulfate 作用下， 以 乙醇 为溶剂， 反应 10.0h， 以83%的产率得到1-(1-(4-bromophenyl)-4-(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)ethanone
  参考文献：
  名称：

  酸性离子液体[BSO3HMIm]HSO4：一种新型高效催化剂，用于一锅三组分合成取代吡咯

  摘要：

  摘要 酸性离子液体 3-甲基-2-(1-磺丁基)-1H-咪唑鎓硫酸氢盐 [BSO3HMIm]HSO4 被用作一种有效的催化剂，通过一锅、三胺、硝基烯烃和 1,3-二羰基化合物的组分缩合。在乙醇中回流下获得了 72-96% 的良好收率。催化剂可以很容易地回收和循环使用多达六次，从而在不延长反应时间的情况下获得良好的收率。这种方法在大规模制备中也是有效的。该程序可以很容易地扩展为一锅四组分反应。这种离子液体催化的反应为吡咯衍生物的合成提供了一种环境友好的替代方法。

  DOI：

  10.1515/znb-2014-0108

文献信息

• Fe3O4@SiO2—CPTMS—Guanidine—SO3H-catalyzed One-Pot Multicomponent Synthesis of Polysubstituted Pyrrole Derivatives under Solvent-Free Conditions
  作者：H. Rostami、L. Shiri

  DOI：10.1134/s1070428019080207

  日期：2019.8

  A highly efficient procedure for the one-pot synthesis of polysubstituted pyrrole derivatives by the reaction between of aniline derivatives, beta-diketones or beta-ketoesters, and beta-nitrostyrene derivatives in the presence of Fe3O4@SiO2-CPTMS-guanidine-SO3H as a reusable magnetic nanocatalyst is reported. The magnetic nanocatalyst was prepared and fully characterized by FTIR spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction analysis, thermogravimetric analysis, and vibrating sample magnetometry.
• Three-component direct synthesis of substituted pyrroles from easily accessible chemical moieties using hypervalent iodine reagent
  作者：Nikhil C. Jadhav、Prashant B. Jagadhane、Hemlata V. Patile、Vikas N. Telvekar

  DOI：10.1016/j.tetlet.2013.04.014

  日期：2013.6

  A novel and simple three-component system has been developed to synthesize substituted pyrroles from corresponding amines and nitrostyrenes using (diacetoxyiodo)benzene at reflux temperature in ethanol. The good to excellent yields were obtained with different types of functional groups. (C) 2013 Elsevier Ltd. All rights reserved.
• 10.1016/j.jphotochem.2024.115863
  作者：Ahmadi, Faezeh、Shariatipour, Monire、Jadidi Nejad, Masoumeh、Heydari, Akbar

  DOI：10.1016/j.jphotochem.2024.115863

  日期：——
• The acidic ionic liquid [BSO₃HMIm]HSO₄: a novel and efficient catalyst for one-pot, three-component syntheses of substituted pyrroles
  作者：Yuan Luo、Bao-Qiang Zhang、Yan-Hong He、Zhi Guan

  DOI：10.1515/znb-2014-0108

  日期：2015.1.1

  was used as an efficient catalyst for the synthesis of a variety of pyrrole derivatives via a one-pot, three-component condensation of amines, nitroolefins, and 1,3-dicarbonyl compounds. Good to excellent yields of 72–96% were obtained under reflux in ethanol. The catalyst could easily be recovered and recycled up to six times, resulting in good yields without prolonging the reaction time. This method

  摘要 酸性离子液体 3-甲基-2-(1-磺丁基)-1H-咪唑鎓硫酸氢盐 [BSO3HMIm]HSO4 被用作一种有效的催化剂，通过一锅、三胺、硝基烯烃和 1,3-二羰基化合物的组分缩合。在乙醇中回流下获得了 72-96% 的良好收率。催化剂可以很容易地回收和循环使用多达六次，从而在不延长反应时间的情况下获得良好的收率。这种方法在大规模制备中也是有效的。该程序可以很容易地扩展为一锅四组分反应。这种离子液体催化的反应为吡咯衍生物的合成提供了一种环境友好的替代方法。