(2-methyl-1H-perimidin-7-yl)(phenyl)methanone | 1146622-22-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-methyl-1H-perimidin-7-yl)(phenyl)methanone
• 英文别名: 6(7)-benzoyl-2-methylperimidine
• CAS: 1146622-22-1
• 化学式: C₁₉H₁₄N₂O
• 分子量: 286.333
• InChiKey: LUKFNEJJECXDDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.55
• 重原子数：
  22.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  41.46
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (2-methyl-1H-perimidin-7-yl)(phenyl)methanone 在 1,2,3,4,5,6,7,8-八硫杂环辛烷 、 potassium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 反应 0.5h， 以76%的产率得到6-methyl-2-phenyl-1-thia-5,7-diazacyclopenta[c,d]phenalene
  参考文献：
  名称：

  的一种简便和有效的合成ñ -取代呋喃并[3,4- b ]茚并[2,1- ë ]吡啶azapodophyllotoxin类似物通过微波辅助的多组分反应

  摘要：

  的有效和简便合成ñ -取代呋喃并[3,4- b ]茚并[2,1- ë ]吡啶azapodophyllotoxin类似物达到通过微波辅助的多组分反应的醛，在没有催化剂的情况下在乙二醇中的2 H-茚-1,3-二酮和4-（芳基氨基）呋喃-2（5 H）-1 。与传统的加热方法相比，该方法具有明显的优势，即反应时间短，产率高，操作简便以及对环境友好。J.杂环化​​学，（2009）。

  DOI：

  10.1002/jhet.187

文献信息

• Synthesis of N-Phenyl-1,5,7-Triazacyclopenta[cd]- Phenalenes by the Reaction of 1H-Perimidine Carbonyl Derivatives with Nitrobenzene
  作者：S. V. Shcherbakov、D. A. Lobach、M. Rubin、A. V. Aksenov

  DOI：10.1007/s10593-014-1531-2

  日期：2014.8
• 6(7)-Acylperimidines nitration and methods of peri-annelation on this base
  作者：A. V. Aksenov、N. A. Aksenov、A. S. Lyakhovnenko、A. N. Smirnov、I. I. Levina、I. V. Aksenova

  DOI：10.1007/s10593-013-1335-9

  日期：2013.10

  A method has been developed for the nitration of 6(7)-acylperimidines using sodium nitrite in formic acid. The reaction gives a mixture of 4(9)-, 9(4)-, and 7(6)-nitro-6(7)-acylperimidines from which the latter can be separated by extraction with chloroform. Reduction of the 6(7)-acyl-7(6)-nitro- perimidines yields 1H-1,5,7-triazacyclopenta[cd]phenalenes. Subsequent Schmidt reaction and reduction give 1,3,6,8-tetraazapyrenes.
• Synthesis of 1-Thia-5,7-Diazacyclopenta[cd]- Phenalenes from 6(7)-Derivatives of Perimidine
  作者：A. V. Aksenov、S. V. Shcherbakov、D. A. Lobach、N. N. Letichevskaya、E. A. Vasil’eva

  DOI：10.1007/s10593-014-1520-5

  日期：2014.8

  Electrochemical oxidation of 6(7)-benzoylperimidines was shown to involve two stages of single electron transfer. Based on cyclic voltammetry and microelectrolysis data, a synthetic method was developed for the peri annelation of thiophene ring to benzoyl derivatives of perimidine. A new method was proposed for the preparation of 1-thia-5,7-diazacyclopenta[cd]phenalenes by fusing 6(7)-carbonyl derivatives of perimidine with elemental sulfur.
• Reaction of 6(7)-acyl-and 6(7)-formylperimidines with 1,3,5-triazines in poly-phosphoric acid
  作者：A. V. Aksenov、I. V. Borovlev、S. V. Pisarenko、I. V. Aksenova

  DOI：10.1007/s10593-008-0121-6

  日期：2008.7

  A method has been developed for the synthesis of 1,3,7-triazapyrenes using the reaction of 6(7)-formyl- and 6(7)-benzoylperimidines with 1,3,5-triazines in PPA. Under these conditions, 6(7)-formylperimidine reacts with 2,4,6-trimethyl-1,3,5-triazine to give 6-hydroxy-1,3-diazapyrene.
• New one pot synthesis of 1H-1,5,7-triazacyclopenta[c,d]phenalenes
  作者：A. S. Lyakhovnenko、N. A. Aksenov、A. S. Kolesnikova、I. V. Aksenova、A. V. Aksenov

  DOI：10.1007/s11172-013-0117-y

  日期：2013.3