1-chloro-4-(cyclohexyloxy)benzene | 31582-87-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-chloro-4-(cyclohexyloxy)benzene
• 英文别名: Cyclohexyl 4-chlorophenyl ether；1-chloro-4-cyclohexyloxybenzene
• CAS: 31582-87-3
• 化学式: C₁₂H₁₅ClO
• 分子量: 210.704
• InChiKey: OWWZCOCQGNCQOM-UHFFFAOYSA-N

物化性质

• 沸点：
  295.0±13.0 °C(Predicted)
• 密度：
  1.121±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  环己基苯醚 在 kaolin 、 sodium chlorite 、 manganese(III) acetylacetonate 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以96%的产率得到1-chloro-4-(cyclohexyloxy)benzene
  参考文献：
  名称：

  高岭土辅助芳香氯化和溴化

  摘要：

  潮湿的高岭土用 NaClO2 和 Mn(acac) 催化 C6H5OR（R=C1-C8 烷基，丁基，烯丙基，环己基，苄基）到 4-XC6H4OR（分别为 X=Cl 和 Br）的区域选择性和高产氯化和溴化在温和和中性条件下，分别在不存在和存在 NaBr 的情况下在 CH2Cl2 中生成 3。

  DOI：

  10.1039/a804043e

文献信息

• Selective aromatic chlorination of activated arenes with sodium chlorite, (salen)manganese(III) complex, and alumina in dichloromethane
  作者：Masao Hirano、Shigetaka Yakabe、Hiroyuki Monobe、Takashi Morimoto

  DOI：10.1139/v97-625

  日期：1997.12.1

  The reaction of alkyl phenyl ethers with sodium chlorite in dichloromethane in the presence of a (salen)manganese(III) complex and alumina preloaded with a small amount of water afforded monochlorination products with unusually high para selectivities under mild conditions. The NaClO₂-based biphasic system can also be successfully used for the regioselective monochlorination of substituted anisoles and polymethoxybenzenes. Keywords: aromatic chlorination, alkyl aryl ethers, sodium chlorite, (salen)manganese(III) complex, alumina.

  烷基苯醚与氯化钠在二氯甲烷中，在（salen）锰（III）配合物和预加载少量水的氧化铝存在下，在温和条件下生成了具有异常高对位选择性的单氯化产物。基于NaClO₂的两相体系也可以成功用于对取代苯酚和多甲氧基苯的区域选择性单氯化。关键词：芳香族氯化、烷基芳基醚、氯化钠、（salen）锰（III）配合物、氧化铝。
• Copper Catalyzed sp³ C–H Etherification with Acyl Protected Phenols
  作者：Tolani K. Salvador、Charles H. Arnett、Subrata Kundu、Nicholas G. Sapiezynski、Jeffery A. Bertke、Mahdi Raghibi Boroujeni、Timothy H. Warren

  DOI：10.1021/jacs.6b09057

  日期：2016.12.28

  A variety of acyl protected phenols AcOAr participate in sp3 C-H etherification of substrates R-H to give alkyl aryl ethers R-OAr employing tBuOOtBu as oxidant with copper(I) β-diketiminato catalysts [CuI]. Although 1°, 2°, and 3° C-H bonds may be functionalized, selectivity studies reveal a preference for the construction of hindered, 3° C-OAr bonds. Mechanistic studies indicate that β-diketiminato

  多种酰基保护的酚 AcOAr 参与底物 RH 的 sp3 CH 醚化，以 tBuOOtBu 作为氧化剂与铜 (I) β-二酮亚胺催化剂 [CuI] 一起得到烷基芳基醚 R-OAr。尽管 1°、2° 和 3° CH 键可以被官能化，但选择性研究表明优先构建受阻的 3° C-OAr 键。机理研究表明，β-二酮亚氨基铜 (II) 酚盐 [CuII]-OAr 在此 CO 键形成反应中起关键作用，通过 AcOAr 与 [CuI]-OtBu 中间体的酯交换反应形成 [CuI] 与 tBuOOtBu 反应。
• The acid-catalysed addition of phenols and acetic acid to alkenes
  作者：D. T. Dalgleish、D. C. Nonhebel、P. L. Pauson

  DOI：10.1039/j39710001174

  日期：——

  High yields of ethers are obtained from the title reaction using fluoroboric acid as catalyst. Competitive reactions between cyclohexene and oct-1-ene show remarkably small but solvent dependent selectivity. Addition of acetic acid to the same pair of alkenes is similarly unselective.

  使用氟硼酸作为催化剂，由标题反应可得到高产率的醚。环己烯和辛-1-烯之间的竞争反应显示出很小的选择性，但取决于溶剂。类似地，将乙酸添加到相同的一对烯烃中是非选择性的。
• Resinous composition capable of releasing a bioactive substance at a controlled rate
  申请人：Nippon Paint Co., Ltd.

  公开号：EP0220965A2

  公开（公告）日：1987-05-06

  A bioactive substance control-releasing resinous composition comprising a resin having main chain and side chains, at least one side chain bearing at the end portion thereof an organic acid moiety having a biological activity through a metal ester bonding. The resin is hydrolyzed in an ionic atmosphere at a controlled rate to generate a bioactive substance as well as metal ions and is useful in various field and especially as resinous vehicle of coating composition.

  一种生物活性物质控制释放树脂组合物，由具有主链和侧链的树脂组成，其中至少一条侧链的末端部分通过金属酯键连接具有生物活性的有机酸分子。该树脂在离子气氛中以可控速率水解，生成生物活性物质和金属离子，可用于各种领域，特别是用作涂料组合物的树脂载体。
• Disintegration type resin particles, its preparation and coating composition containing the same
  申请人：Nippon Paint Co., Ltd.

  公开号：EP0286243A1

  公开（公告）日：1988-10-12

  Disintegration type resin particles having an average grain diameter of 0.01 to 250u. and being composed of a crosslinked resin having at least one crosslinking structure carried metal ester bond of the formula: R1 is a monovalent, bioactive organic acid residue; M stands for a polyvalent metal having a valence of 3 or more; m is an integer of 2 or more; n is an integer of 1 or more, providing that the sum of m and n is equal to the valence of said metal @, and a coating composition containing said resin particles are provided. The coating obtained is characterized in that it is gradually hydrolyzed in an ionic atmosphere as in sea water and dissolved out, liberating a bioactive organic acid as well as metal ions.

  崩解型树脂颗粒，其平均粒径为 0.01 至 250u： R1 是一价的生物活性有机酸残基；M 代表价数为 3 或更多的多价金属；m 是 2 或更多的整数；n 是 1 或更多的整数，条件是 m 和 n 的总和等于所述金属 @ 的价数；本发明还提供了一种含有所述树脂颗粒的涂料组合物。所获得的涂层的特征在于，它在海水等离子环境中逐渐水解并溶解，释放出生物活性有机酸和金属离子。