(19-Ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl) 2-(methylamino)acetate

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 喜树碱
• 英文名称: (19-Ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl) 2-(methylamino)acetate
• 化学式: C₂₃H₂₁N₃O₅
• 分子量: 419.4
• InChiKey: VKZTYDFCSYWAFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  97.8
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Nanoparticles For Crossing The Blood Brain Barrier And Methods Of Treatment Using The Same
  申请人：California Institute of Technology

  公开号：US20210220483A1

  公开（公告）日：2021-07-22

  The present application discloses nanoparticles carrying therapeutic agents, including chemotherapeutic agents, and targeting ligands suitable for delivering these therapeutic agents through the blood brain barrier and methods of using these patients on those patients in need of such treatment.