1H-Benzo[a]carbazole-1,4(11H)-dione, 8-methoxy-11-methyl-

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1H-Benzo[a]carbazole-1,4(11H)-dione, 8-methoxy-11-methyl-
• 英文别名: 8-methoxy-11-methylbenzo[a]carbazole-1,4-dione
• 化学式: C₁₈H₁₃NO₃
• 分子量: 291.3
• InChiKey: NJELFFLROCNKMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  48.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Inhibitors of SARM1 NADase activity and uses thereof
  申请人：Washington University

  公开号：US11253503B2

  公开（公告）日：2022-02-22

  The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.

  本公开提供了可用作 SARM1 NAD 酶活性抑制剂的化合物、其组合物及其使用方法。本公开提供了用于治疗神经退行性或神经疾病或紊乱的化合物、其组合物以及使用方法。
• INHIBITORS OF SARM1 NADASE ACTIVITY AND USES THEREOF
  申请人：WASHINGTON UNIVERSITY

  公开号：US20200129493A1

  公开（公告）日：2020-04-30

  The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.