Essigsaeure-isopropyloxymethylester | 67780-83-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Essigsaeure-isopropyloxymethylester
• 英文别名: acetic acid isopropoxymethyl ester；Essigsaeure-isopropoxymethylester；Methylenglykol-isopropylaether-acetat；Isopropyloxymethyl-acetat；isopropoxymethyl acetate；Propan-2-yloxymethyl acetate
• CAS: 67780-83-0
• 化学式: C₆H₁₂O₃
• 分子量: 132.159
• InChiKey: XEEJTPOVAUVVLF-UHFFFAOYSA-N

物化性质

• 沸点：
  134-135 °C
• 密度：
  0.9304 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  氯甲基异丙基醚 、 sodium acetate 生成 Essigsaeure-isopropyloxymethylester
  参考文献：
  名称：

  Farren et al., Journal of the American Chemical Society, 1925, vol. 47, p. 2422

  摘要：

  DOI：

文献信息

• COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN
  申请人：Global Blood Therapeutics, Inc.

  公开号：US20150141465A1

  公开（公告）日：2015-05-21

  Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

  本文提供了适用作为血红蛋白调节剂的化合物和药物组合物，它们的制备方法和中间体，以及在治疗由血红蛋白介导的疾病和需要组织和/或细胞氧合的疾病中使用它们的方法。
• RESIST POLYMER, RESIST COMPOSITION, PROCESS FOR PATTERN FORMATION, AND STARTING COMPOUNDS FOR PRODUCTION OF THE RESIST POLYMER
  申请人：Momose Hikaru

  公开号：US20090198065A1

  公开（公告）日：2009-08-06

  To provide a resist polymer comprising, as a structural unit, an acid-decomposable unit having a structure represented by formula (1) or (2) which exhibits a small line edge roughness and produces little defects in DUV excimer laser lithography or the like. In formulas (1) and (2), n represents an integer of 2 to 24; J represents a single bond or a divalent hydrocarbon group which may have a substituent/heteroatom when n=2, or represents an n-valent hydrocarbon group which may have a substituent/heteroatom when n≧3; E represents a residue of a polymerization terminator, a chain transfer agent or a polymerization initiator; K 1 and K 2 each represent at least one selected from alkylene, cycloalkylene, oxyalkylene, arylene, a divalent thiazoline ring, a divalent oxazoline ring and a divalent imidazoline ring; L 1 and L 2 each represent at least one selected from —C(O)O—, —C(O)— and —OC(O)—; M 1 , M 2 and M 3 each represent at least one selected from alkylene, cycloalkylene, oxyalkylene and arylene; Y, Y 1 and Y 2 each represent an acid-decomposable linkage; k1, k2, l1, l2, m1, m2, and m3 each represent 0 or 1; and R 1 represents H or a methyl group.

  提供一种抗蚀聚合物，其由一个具有结构式（1）或（2）所表示的酸分解单元作为结构单元，能够在DUV准分子激光微影或类似工艺中表现出小的线边粗糙度并产生少量缺陷。在式（1）和（2）中，n表示2至24的整数；J表示单键或二价碳氢基团，当n=2时可以具有取代基/杂原子，或者当n≥3时可以表示n价碳氢基团，可以具有取代基/杂原子；E表示聚合终止剂、链转移剂或聚合引发剂的残基；K1和K2分别表示至少选择自烷基、环烷基、氧烷基、芳烃、二价噻唑环、二价噁唑环和二价咪唑环中的至少一种；L1和L2分别表示至少选择自—C（O）O—、—C（O）—和—OC（O）—中的至少一种；M1、M2和M3分别表示至少选择自烷基、环烷基、氧烷基和芳烃中的至少一种；Y、Y1和Y2分别表示酸分解键；k1、k2、l1、L2、m1、m2和m3分别表示0或1；R1表示H或甲基基团。
• Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds
  申请人：Arimilli N. Murty

  公开号：US20070010489A1

  公开（公告）日：2007-01-11

  Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit 5 HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.

  本发明揭示了具有HIV蛋白酶抑制剂性质的膦酸酯取代化合物，其具有作为治疗剂和其他工业用途的用途。该组合物抑制5型HIV蛋白酶活性和/或在治疗艾滋病和其他抗病毒感染方面具有治疗作用，以及在检测HIV蛋白酶方面的检测中有用。
• Liquid coating composition curable at ambient temperature
  申请人：AKZO N.V.

  公开号：EP0161697A1

  公开（公告）日：1985-11-21

  The invention provides a liquid coating composition curable at ambient temperature based on an α,β-ethylenically unsaturated carbonyl compound and a particular compound with an activated CH group such as a malonic oligomer or polymer.

  本发明提供了一种可在环境温度下固化的液体涂料组合物，它基于一种 α、β-乙烯基不饱和羰基化合物和一种带有活化 CH 基团（如丙二酸低聚物或聚合物）的特定化合物。
• New chain-terminated N-vinyl lactam polymers and graft-copolymers and methods for making same
  申请人：CONSIGLIO NAZIONALE DELLE RICERCHE

  公开号：EP0587357A2

  公开（公告）日：1994-03-16

  A water-soluble polyvinyl 5-membered lactam having a molecular weight ranging from about 1000 to about 20,000 and chain-terminated with a compound selected from the group consisting of compounds of the following formulas and wherein R and R1 are C1 to C4 alkyl or substituted alkyl ; n is 0 to 20 ; R" is ethylene ; Rill is C1 to C24 alkylene or substituted alkylene ; and RIV is C1 to C4 alkyl or substituted alkyl ; can be prepared by polymerizing an N-vinyl 5-membered lactam in a liquid solvent-chain terminator compound of the formula (I) or (II) in the presence of a free radical initiator. The lactam polymer so-obtained may be activated and grafted to (conjugated with) a drug or an enzyme to alter the properties thereof.

  一种水溶性聚乙烯醇 5 元内酰胺，其分子量在约 1000 至约 20000 之间，并以一种选自由下列式子的化合物组成的组中的化合物进行链端化 和 其中 R 和 R1 为 C1 至 C4 烷基或取代烷基；n 为 0 至 20；R "为乙烯；Rill 为 C1 至 C24 亚烷基或取代亚烷基；RIV 为 C1 至 C4 烷基或取代烷基；可通过在自由基引发剂存在下，在式 (I) 或 (II) 的液态溶剂-链终止剂化合物中聚合 N-乙烯基五元内酰胺来制备。这样得到的内酰胺聚合物可以活化并接枝到（与）药物或酶上，以改变其性质。