(9S,10S)-5-Methoxy-9-methyl-10-phenylamino-9,10-dihydro-phenanthren-9-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: (9S,10S)-5-Methoxy-9-methyl-10-phenylamino-9,10-dihydro-phenanthren-9-ol
• 英文别名: (9S,10S)-10-anilino-5-methoxy-9-methyl-10H-phenanthren-9-ol
• 化学式: C₂₂H₂₁NO₂
• 分子量: 331.414
• InChiKey: ZIXNGCFHBHNXIY-VXKWHMMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 以 乙醚 为溶剂， 反应 1.0h， 以98%的产率得到(9S,10S)-5-Methoxy-9-methyl-10-phenylamino-9,10-dihydro-phenanthren-9-ol
  参考文献：
  名称：

  Enantiomerically Pure Cyclic trans-1,2-Diols, Diamines, and Amino Alcohols by Intramolecular Pinacol Coupling of Planar Chiral Mono-Cr(CO)3 Complexes of Biaryls

  摘要：

  Without any formation of stereoisomers, the intramolecular pinacol cyclization of 1-planar chiral mono-Cr(CO)3 complexes of 1,1'-biphenyls with carbonyl functionalities at the 2- and 2'-positions-with samarium diiodide gives cyclic trans-1,2-diols 2. Upon exposure to sunlight, the chromium-complexed diols 2 produce optically pure chromium-free trans-diols 3. Similarly, the corresponding enantiomerically pure trans-1,2-diamines and amino alcohols are obtained from the planar chiral chromium complexes of biphenyls with diimino or keto-imino functionalities. R1 =H, OMe; R2 =H, Me; R3 =H, Me.

  DOI：

  10.1002/(sici)1521-3773(19990503)38:9<1232::aid-anie1232>3.0.co;2-e