10-(Hydroxymethyl)-9-((methylimino)methyl)anthracene | 191417-59-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 10-(Hydroxymethyl)-9-((methylimino)methyl)anthracene
• 英文别名: [10-(methyliminomethyl)anthracen-9-yl]methanol
• CAS: 191417-59-1
• 化学式: C₁₇H₁₅NO
• 分子量: 249.312
• InChiKey: LOWZVDWXPGIHCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  10-(Hydroxymethyl)-9-((methylimino)methyl)anthracene 在 sodium tetrahydroborate 、 potassium carbonate 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 乙腈 为溶剂， 生成 [2-[[methyl-[[10-[[(2-methylpropan-2-yl)oxycarbonyl-[N'-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]amino]methyl]anthracen-9-yl]methyl]amino]methyl]phenyl]boronic acid
  参考文献：
  名称：

  The first fluorescent sensor for d-glucarate based on the cooperative action of boronic acid and guanidinium groups

  摘要：

  一种新型荧光传感器（1）的识别单元由一个硼酸分子和一个胍单元组成，能在水溶液中选择性地结合 D-葡萄糖酸盐。

  DOI：

  10.1039/b300098b
• 作为产物：
  描述：

  10-(hydroxymethyl)-9-anthraldehyde 、 甲胺 以 四氢呋喃 、 甲醇 为溶剂， 生成 10-(Hydroxymethyl)-9-((methylimino)methyl)anthracene
  参考文献：
  名称：

  The first fluorescent sensor for d-glucarate based on the cooperative action of boronic acid and guanidinium groups

  摘要：

  一种新型荧光传感器（1）的识别单元由一个硼酸分子和一个胍单元组成，能在水溶液中选择性地结合 D-葡萄糖酸盐。

  DOI：

  10.1039/b300098b

文献信息

• Detection of biological molecules using chemical amplification and optical sensors
  申请人：Minimed Inc.

  公开号：US20020018843A1

  公开（公告）日：2002-02-14

  Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.

  本发明提供了一种测定生物水平下多羟基化合物浓度的方法，特别是葡萄糖。该方法利用一种放大系统，该放大系统是固定在聚合物基质中的分析物转换器，该系统可植入并与生物相容。通过光学系统的询问，放大系统产生一个能够在患者皮肤外部检测到的信号。通过测量发射信号来实现对感兴趣的分析物的定量。
• Detection of biological molecules using boronate-based chemical
  申请人：The Regents of the University of California

  公开号：US06002954A1

  公开（公告）日：1999-12-14

  Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.

  本发明提供了一种测定生物水平多羟基化合物浓度的方法，特别是葡萄糖。该方法利用了一种放大系统，即在聚合物基质中固定的分析物转换器，该系统可植入并与生物相容。在通过光学系统询问后，放大系统产生一个能够在患者皮肤外部检测到的信号。通过测量发射信号来实现对感兴趣分析物的定量。
• Detection of biological molecules using chemical amplification and
  申请人：Minimed Inc.

  公开号：US06011984A1

  公开（公告）日：2000-01-04

  Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.

  本发明提供了一种测定生物水平多羟基化合物浓度的方法，特别是葡萄糖。该方法利用一种放大系统，该系统是固定在聚合物基质中的分析物传感器，该系统可植入并生物相容。在光学系统的检测下，放大系统产生一个能够在患者皮肤外检测到的信号。通过测量发射信号来实现感兴趣分析物的定量。
• Detection of biological molecules using boronate-based chemical amplification and optical sensors
  申请人：MiniMed Inc.

  公开号：US06750311B1

  公开（公告）日：2004-06-15

  Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.

  提供了一种测定生物水平中多羟基化合物浓度的方法，特别是葡萄糖。该方法利用了一种放大系统，即被固定在聚合物基质中的分析物转换器，该系统可植入且生物相容性好。在光学系统的检测下，放大系统产生了一个能够在患者皮肤外部检测到的信号。通过测量发射信号来实现对感兴趣分析物的定量分析。
• Diboronic acids as fluorescent probes for cells expressing sialyl lewis X
  作者：Wenqian Yang、Shouhai Gao、Xingming Gao、Vishnu Vardhan Reddy Karnati、Weijuan Ni、Binghe Wang、W.Borden Hooks、John Carson、Brent Weston

  DOI：10.1016/s0960-894x(02)00339-6

  日期：2002.8

  A series of fluorescent diboronic acids was synthesized in nine steps as potential sensors for sialyl Lewis X (sLex). The fluorescent binding studies of these sensors with sLex were carried out in a mixed aqueous solution. Compound 7e was found to show the strongest fluorescence enhancement upon binding with sLex. Using cell cultures, 7e was shown to label sLex-expressing HEPG2 cells at 1 muM, while non-sLex-expressing cells were not labeled. (C) 2002 Elsevier Science Ltd. All rights reserved.