rac-1,4,4-trimethylpyrrolidin-3-amine | 1316341-76-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: rac-1,4,4-trimethylpyrrolidin-3-amine
• 英文别名: 1,4,4-Trimethylpyrrolidin-3-amine
• CAS: 1316341-76-0
• 化学式: C₇H₁₆N₂
• 分子量: 128.217
• InChiKey: NRLXIAXXAJJILW-UHFFFAOYSA-N

物化性质

• 沸点：
  132.3±8.0 °C(Predicted)
• 密度：
  0.879±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  rac-1,4,4-trimethylpyrrolidin-3-amine 在 盐酸 作用下， 以 甲醇 为溶剂， 以1.33 g的产率得到rac-1,4,4-trimethylpyrrolidin-3-amine dihydrochloride
  参考文献：
  名称：

  Diastereoselective preparation of (S)-(1,4,4-trimethylpyrrolidin-3-yl)amine, a new chiral 1,2-diamine for thiourea-type organocatalysts

  摘要：

  The enantioselective synthesis of the title compound, its conversion into a thiourea-type organocatalyst and the behavior of this organocatalyst in several enantioselective Michael reactions are described. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2011.04.002
• 作为产物：
  描述：

  (+/-)-3-hydroxy-1,4,4-trimethyl-2-pyrrolidinone 在 盐酸 、 硼烷四氢呋喃络合物 、 sodium dichromate dihydrate 、 硫酸 、 5% Pd(II)/C(eggshell) 、 氢气 、 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 四氢呋喃 、 甲醇 、 水 、 甲苯 为溶剂， 30.0 ℃ 、101.33 kPa 条件下， 反应 54.75h， 生成 rac-1,4,4-trimethylpyrrolidin-3-amine
  参考文献：
  名称：

  Diastereoselective preparation of (S)-(1,4,4-trimethylpyrrolidin-3-yl)amine, a new chiral 1,2-diamine for thiourea-type organocatalysts

  摘要：

  The enantioselective synthesis of the title compound, its conversion into a thiourea-type organocatalyst and the behavior of this organocatalyst in several enantioselective Michael reactions are described. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2011.04.002

文献信息

• PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT-2
  申请人：Wells Kenneth M.

  公开号：US20140206859A1

  公开（公告）日：2014-07-24

  The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.

  本发明涉及一种新型的制备具有抑制肠道或肾脏中存在的钠依赖性葡萄糖转运体（SGLT）活性的化合物的方法。
• Carboxamides as ubiquitin-specific protease inhibitors
  申请人：Valo Early Discovery, Inc.

  公开号：US11524966B1

  公开（公告）日：2022-12-13

  The present disclosure relates to modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors. The modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25 can be useful in the treatment of cancers, among other ailments.

  本公开涉及选自USP28和USP25的至少一种通路的调节剂（如抑制剂）、包含这些抑制剂的药物组合物以及使用这些抑制剂的方法。选自USP28和USP25的至少一种通路的调节剂（如抑制剂）可用于治疗癌症等疾病。
• CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS
  申请人：Valo Early Discovery, Inc.

  公开号：US20210323975A1

  公开（公告）日：2021-10-21

  The present disclosure relates to modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors. The modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25 can be useful in the treatment of cancers, among other ailments.
• US7582627B2
  申请人：——

  公开号：US7582627B2

  公开（公告）日：2009-09-01
• Diastereoselective preparation of (S)-(1,4,4-trimethylpyrrolidin-3-yl)amine, a new chiral 1,2-diamine for thiourea-type organocatalysts
  作者：Pelayo Camps、Carles Galdeano、Diego Muñoz-Torrero、Jordi Rull、Teresa Calvet、Mercè Font-Bardia

  DOI：10.1016/j.tetasy.2011.04.002

  日期：2011.4

  The enantioselective synthesis of the title compound, its conversion into a thiourea-type organocatalyst and the behavior of this organocatalyst in several enantioselective Michael reactions are described. (C) 2011 Elsevier Ltd. All rights reserved.