2-Hydrazinyl-5-iodobenzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Hydrazinyl-5-iodobenzoic acid
• 化学式: C₇H₇IN₂O₂
• 分子量: 278.05
• InChiKey: UZGJBDDZOZMFSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  75.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] METHODS AND COMPOUNDS FOR DETECTION AND BINDING OF ALEDHYDES<br/>[FR] PROCÉDÉS ET COMPOSÉS DE DÉTECTION ET DE LIAISON D'ALDÉHYDES
  申请人：UNIV OTTAWA

  公开号：WO2018141069A1

  公开（公告）日：2018-08-09

  Methods of detecting an aldehyde-containing compound in a subject or in a sample from a subject are described herein, comprising administering an aldehyde-binding compound of Formula I to the subject, or combining such a compound with the sample; and detecting the product of the compound of Formula I and the aldehyde-containing compound. Detection of the product may involve imaging, such as MRI, CEST-MRI or positron emission tomography (PET) imaging; or may involve fluorescence or an electrochemical detection method. Biologically relevant aldehydes detected according to the described method can be used to monitor conditions such as brain injury, neurodegenerative disorders such as Alzheimer's disease, diabetes, heart disease, and cancer. Formula (I)

  本文描述了检测主体或来自主体样本中含有醛基化合物的方法，包括向主体中给予Formula I的醛结合化合物，或将这种化合物与样本结合；并检测Formula I化合物与含有醛基化合物的产物。产物的检测可以涉及成像，如MRI、CEST-MRI或正电子发射断层扫描（PET）成像；或涉及荧光或电化学检测方法。根据所述方法检测到的具有生物学意义的醛类化合物可用于监测脑损伤、神经退行性疾病（如阿尔茨海默病）、糖尿病、心脏病和癌症等疾病的情况。Formula (I)。
• METHODS AND COMPOUNDS FOR DETECTION AND BINDING OF ALDEHYDES
  申请人：UNIVERSITY OF OTTAWA

  公开号：US20200376144A1

  公开（公告）日：2020-12-03

  Methods of detecting an aldehyde-containing compound in a subject or in a sample from a subject are described herein, comprising administering an aldehyde-binding compound of Formula I to the subject, or combining such a compound with the sample; and detecting the product of the compound of Formula I and the aldehyde-containing compound. Detection of the product may involve imaging, such as MRI, CEST-MRI or positron emission tomography (PET) imaging; or may involve fluorescence or an electrochemical detection method. Biologically relevant aldehydes detected according to the described method can be used to monitor conditions such as brain injury, neurodegenerative disorders such as Alzheimer's disease, diabetes, heart disease, and cancer. Formula (I)