NSC 17383

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: NSC 17383
• 英文别名: 2-[1-[(2-chlorophenyl)methyl]-2-methyl-5-methylsulfanylindol-3-yl]ethanamine；2-(1-(2-chlorobenzyl)-2-methyl-5-(methylthio)-1H-indol-3-yl)ethanamine
• 化学式: C₁₉H₂₁ClN₂S
• 分子量: 344.908
• InChiKey: XNGZKLFCPYJUAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  56.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• SHIP INHIBITION TO COMBAT OBESITY
  申请人：KERR William G.

  公开号：US20160129017A1

  公开（公告）日：2016-05-12

  The present invention relates to the use of SHIP1 inhibitors and pan-SHIP1/2 inhibitors in various methods, including, without limitation: (i) a method to treat obesity or reduce body fat of an obese subject; (ii) a method to limit bone development in a subject suffering from an osteopetrotic or sclerotic disease; (iii) a method to treat or prevent diabetes; (iv) a method to reduce glucose intolerance or insulin resistance; and (v) a method to lower cholesterol.

  本发明涉及使用SHIP1抑制剂和pan-SHIP1/2抑制剂在各种方法中的应用，包括但不限于：（i）治疗肥胖或减少肥胖患者的体脂肪的方法；（ii）限制骨发育在患有骨质疏松或硬化病的患者中的方法；（iii）治疗或预防糖尿病的方法；（iv）减少葡萄糖不耐受或胰岛素抵抗的方法；以及（v）降低胆固醇的方法。
• Ship inhibition to induce activation of natural killer cells
  申请人：THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

  公开号：US10702538B2

  公开（公告）日：2020-07-07

  The present invention relates to the use of SHIP1 inhibitors and pan-SHIP1/2 inhibitors in various methods, including, without limitation, a method of inhibiting SHIP to induce broad activation of natural killer (NK) cells to treat various diseases.

  本发明涉及 SHIP1 抑制剂和泛 SHIP1/2 抑制剂在各种方法中的使用，包括但不限于抑制 SHIP 以诱导自然杀伤（NK）细胞广泛活化从而治疗各种疾病的方法。
• ONCOGENIC RAS-SPECIFIC CYTOTOXIC COMPOUND AND METHODS OF USE THEREOF
  申请人：The Board of Regents of The University of Texas System

  公开号：EP1956910B1

  公开（公告）日：2014-09-17
• SHIP INHIBITION TO INDUCE EXPRESSION OF GRANULOCYTE COLONY STIMULATING FACTOR IN A SUBJECT
  申请人：THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

  公开号：US20170128461A1

  公开（公告）日：2017-05-11

  The present invention relates to the use SHIP inhibitors to induce expression of granulocyte colony stimulating factor (G-CSF) in a subject, thereby promoting expansion of hematopoietic and mesenchymal stem cells.
• SHIP INHIBITION TO INDUCE ACTIVATION OF NATURAL KILLER CELLS
  申请人：THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

  公开号：US20170151262A1

  公开（公告）日：2017-06-01

  The present invention relates to the use or SHIP1 inhibitors and pan-SHIP1/2 inhibitors in various methods, including, without limitation, a method of inhibiting SHIP to induce broad activation of natural killer (NK) cells to treat various diseases.