N-(2-Nitro-benzoyl)-DL-alanin | 10167-25-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-Nitro-benzoyl)-DL-alanin
• 英文别名: N-(2-nitro-benzoyl)-alanine；N-(2-Nitro-benzoyl)-alanin；2-[(2-Nitrobenzoyl)amino]propanoic acid
• CAS: 10167-25-6
• 化学式: C₁₀H₁₀N₂O₅
• mdl: MFCD09733448
• 分子量: 238.2
• InChiKey: URZWEYDWSCEMJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  DL-丙氨酸 、 2-硝基苯甲酰氯 在 氢氧化钾 、 苯 作用下， 生成 N-(2-Nitro-benzoyl)-DL-alanin
  参考文献：
  名称：

  High-resolution quantitative imaging of plagioclase composition using accumulated backscattered electron images: new constraints on oscillatory zoning

  摘要：

  Oscillatory zoning in plagioclase is investigated at small scale (less than or equal to10 mum) using accumulated backscattered electron (BSE) images as high-resolution imaging method. Combined with electron microprobe quantitative analysis. gray-value profiles across these images can be calibrated for An-content with a resolution of 0.5 mol% An. Applied to oscillatory-zoned crystals. this new application of BSE imaging allows better characterization of zoning patterns along a profile and quantification of wavelength. amplitude, and shape of the oscillations. We also obtain high-resolution information on the morphology of growth zones boundaries. This approach allows us to better classify the different types of "oscillations" and concentric zoning. Dissolution is more frequent than usually recognized. Major resorption surfaces crosscut several growth zones. Irregular 5-10-mum saw-tooth zones are delimited by faint wavy dissolution surfaces and must be distinguished from small-scale oscillations (less than or equal to1-3 pm) with straight boundaries. This suggests at least two mechanisms for the formation of these zoning patterns: faint oscillations are probably caused by local kinetic control whereas wavy dissolution surfaces involve magma chamber dynamics.

  DOI：

  10.1007/s004100100298

文献信息

• METHODS AND COMPOSITIONS FOR THE TREATMENT OF ALCOHOLISM AND ALCOHOL DEPENDENCE
  申请人：Cardiff and Vale National Health Service Trust

  公开号：EP1294377A2

  公开（公告）日：2003-03-26
• Novel medical use of kynurenic acid, its precursors and derivatives
  申请人：Marciniak Andrzej

  公开号：US20120029015A1

  公开（公告）日：2012-02-02

  The invention relates to the use of kynurenic acid derivatives of general formula (I), wherein R 1 is hydroxy, NHR 2 , NR 2 R 2 or C 1-10 straight or branched alkoxy or glyceryl group; R 2 is hydrogen atom or C 1-10 straight or branched alkyl group; R 3 -R 6 are independently of each other hydrogen atom, halogen atom, C 1-10 alkyl, C 2-10 alkenyl or alkynyl group optionally substituted with a halogen atom, and a pharmaceutically acceptable salt, ester or amide thereof in manufacturing of a drug used in prevention and therapy of pancreas disorders characterized by edema and/or vacuolization and/or destruction of pancreatic tissue and/or pancreas necrosis leading to release of pancreatic α-amylase. Preferably, in the compound represented by formula (I) R 1 is a hydroxy, NH 2 , NH—(C 1-5 straight or branched alkyl) or C 1-5 straight or branched-alkoxy or glyceryl group; R 2 is a hydrogen atom; R 3 -R 6 are independently of each other a hydrogen atom, halogen atom or CF 3 group. In the most preferred embodiment, the invention concerns the use of kynurenic acid or its pharmaceutically acceptable salt in manufacturing of a drug used in prevention and therapy of pancreas disorders characterized by edema and/or vacuolization and/or destruction of pancreatic tissue and/or pancreas necrosis leading to release of pancreatic α-amylase.
• [EN] METHODS AND COMPOSITIONS FOR THE TREATMENT OF ALCOHOLISM AND ALCOHOL DEPENDENCE<br/>[FR] METHODES ET COMPOSITIONS DE TRAITEMENT DE L'ALCOOLISME ET DE LA DEPENDANCE A L'ALCOOL
  申请人：CARDIFF AND VALE NHS TRUST

  公开号：WO2002002091A2

  公开（公告）日：2002-01-10

  Use is disclosed of (a) an AlDH-inhibitory amount of a Trp metabolite, or an analogue or derivative thereof or (b) a bioprecursor thereof, or (c) a potentiator of (a) and/or (b), in the preparation of a medicament for treating alcoholism and/or alcohol dependence.
• [EN] A NOVEL MEDICAL USE OF KYNURENIC ACID, ITS PRECURSORS AND DERIVATIVES<br/>[FR] NOUVELLE UTILISATION MÉDICALE DE L'ACIDE CYNURÉNIQUE, DE SES PRÉCURSEURS ET DÉRIVÉS
  申请人：MARCINIAK ANDRZEJ

  公开号：WO2010110689A1

  公开（公告）日：2010-09-30

  The invention relates to the use of kynurenic acid derivatives of general formula (I), wherein R1 is hydroxy, NHR2, NR2R2 or C1-10 straight or branched alkoxy or glyceryl group; R2 is hydrogen atom or C1-10 straight or branched alkyl group; R3-R6 are independently of each other hydrogen atom, halogen atom, C1-10 alkyl, C2-10 alkenyl or alkynyl group optionally substituted with a halogen atom, and a pharmaceutically acceptable salt, ester or amide thereof in manufacturing of a drug used in prevention and therapy of pancreas disorders characterized by edema and/or vacuolization and/or destruction of pancreatic tissue and/or pancreas necrosis leading to release of pancreatic α-amylase. Prefereably, in the compound represented by formula (I) R1 is a hydroxy, NH2, NH-(C1-5 straight or branched alkyl) or C1-5 straight or branched- alkoxy or glyceryl group; R2 is a hydrogen atom; R3-R6 are independently of each other a hydrogen atom, halogen atom or CF3 group. In the most preferred embodiment, the invention concerns the use of kynurenic acid or its pharmaceutically acceptable salt in manufacturing of a drug used in prevention and therapy of pancreas disorders characterized by edema and/or vacuolization and/or destruction of pancreatic tissue and/or pancreas necrosis leading to release of pancreatic α-amylase.
• High-resolution quantitative imaging of plagioclase composition using accumulated backscattered electron images: new constraints on oscillatory zoning
  作者：Catherine Ginibre、Andreas Kronz、Gerhard Wörner

  DOI：10.1007/s004100100298

  日期：2002.1

  Oscillatory zoning in plagioclase is investigated at small scale (less than or equal to10 mum) using accumulated backscattered electron (BSE) images as high-resolution imaging method. Combined with electron microprobe quantitative analysis. gray-value profiles across these images can be calibrated for An-content with a resolution of 0.5 mol% An. Applied to oscillatory-zoned crystals. this new application of BSE imaging allows better characterization of zoning patterns along a profile and quantification of wavelength. amplitude, and shape of the oscillations. We also obtain high-resolution information on the morphology of growth zones boundaries. This approach allows us to better classify the different types of "oscillations" and concentric zoning. Dissolution is more frequent than usually recognized. Major resorption surfaces crosscut several growth zones. Irregular 5-10-mum saw-tooth zones are delimited by faint wavy dissolution surfaces and must be distinguished from small-scale oscillations (less than or equal to1-3 pm) with straight boundaries. This suggests at least two mechanisms for the formation of these zoning patterns: faint oscillations are probably caused by local kinetic control whereas wavy dissolution surfaces involve magma chamber dynamics.