5-[2-(4-羧基苯基)偶氮]-2-羟基-苯甲酸 | 64896-26-0

• 物质功能分类: 有机原料 - 重氮、偶氮或氧化偶氮化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 中文名称: 5-[2-(4-羧基苯基)偶氮]-2-羟基-苯甲酸
• 英文名称: 5-[2-(4-carboxyphenyl)diazen-1-yl]-2-hydroxybenzoic acid
• 英文别名: 5-[[4-carboxyphenyl]azo]-2-hydroxybenzoic acid；5-(4-carboxyphenylazo)salicyilic acid；benzalazine；des-β-alanine balsalazide；Salicylazobenzoic acid；5-[(4-carboxyphenyl)diazenyl]-2-hydroxybenzoic acid
• CAS: 64896-26-0
• 化学式: C₁₄H₁₀N₂O₅
• mdl: MFCD00941122
• 分子量: 286.244
• InChiKey: JNVGBRQYZHTBTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  120
• 氢给体数：
  3
• 氢受体数：
  7

安全信息

• 海关编码：
  2927000090
• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  室温

反应信息

• 作为反应物：
  描述：

  乙醇 、 5-[2-(4-羧基苯基)偶氮]-2-羟基-苯甲酸 、 copper(II) acetate monohydrate 、 N,N-二甲基甲酰胺 反应 1.0h， 生成
  参考文献：
  名称：

  Ultrasonic-assisted synthesis of copper(II) azo coordination polymers, new precursors for direct preparation of metalic copper nano-particles

  摘要：

  Nanostructures of coordination polymers, (CuL1). 0.5DMF. 0.5EtOH. 1.5H(2)O (1), = [H2L1 = 5-(4-Carboxy phenyl azo) salicyilic acid], (Cu(L-2)(2)) (2), [HL2 = 5-(4-Carboxy phenyl azo) salicylaldehyde] have been synthesized by the reaction of H2L1 and HL2 with Cu(OAc)(2)center dot H2O by sonochemical process. CuO nanostructures were synthesized from calcination and thermal decomposition of compounds 1-2 nanostructures. Metalic copper nanoparticles were prepared by direct calcination of compounds 1-2 in surfactant at 180 degrees C. These nanostructures were characterized by X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). Thermal stability of compounds 1-2 was studied by thermal gravimetric (TG) and differential thermal analyses (DTA). (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2013.12.014
• 作为产物：
  描述：

  对氨基苯甲酸 、 水杨酸 在 盐酸 、 sodium nitrite 作用下， 以 水 为溶剂， 以100%的产率得到5-[2-(4-羧基苯基)偶氮]-2-羟基-苯甲酸
  参考文献：
  名称：

  Synthesis and Characterization of Metabolites and Potential Impurities of Balsalazide Disodium, an Anti-Inflammatory Drug

  摘要：

  Balsalazide disodium (Colazide (R)) is an oral prodrug of mesalamine (5-aminosalicylic acid) and possesses anti-inflammatory properties. During the process development for balsalazide disodium, we observed eight impurities, namely des--alanine balsalazide, balsalazide -alanine, balsalazide 3-isomer, decarboxy balsalazide, bis-azo salicylic acid, biphenyl-azo salicylic acid, bis-azo diacid, and bis-azo triacid. The present work describes the synthesis and characterization of these impurities.

  DOI：

  10.1080/00397910903221068