3-(5,11-dimethyl-6H-pyrido[4,3-b]carbazol-6-yl)-1-propanamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(5,11-dimethyl-6H-pyrido[4,3-b]carbazol-6-yl)-1-propanamine
• 英文别名: 3-(5,11-dimethylpyrido[4,3-b]carbazol-6-yl)propan-1-amine
• 化学式: C₂₀H₂₁N₃
• 分子量: 303.4
• InChiKey: NYSZCISINQPRPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Remote detection of substance delivery to cells
  申请人：Drummond C. Daryl

  公开号：US20050112065A1

  公开（公告）日：2005-05-26

  The present invention provides for the development of endocytosis-sensitive probes, and a remote method for measuring cellular endocytosis. These probes are based on the reduced water permeability of a nanoparticle or liposomal delivery system, and inherent degradability or disruption of barrier integrity upon endocytosis. The invention also provides for liposomes having combined therapeutic and diagnostic utilities by co-encapsulating ionically coupled diagnostic and therapeutic agents, in one embodiment, by a method using anionic chelators to prepare electrochemical gradients for loading of amphipathic therapeutic bases into liposomes already encapsulating an imaging agent. The invention provides for imaging of therapeutic liposomes by inserting a lipopolymer anchored, remotely sensing reporter molecules into liposomal lipid layer. The invention allows for an integrated delivery system capable of imaging molecular fingerprints in diseased tissues, treatment, and treatment monitoring.

  本发明提供了一种用于开发内吞敏感探针的方法，以及一种测量细胞内吞的远程方法。这些探针基于纳米颗粒或脂质体递送系统的降低水透性，以及内吞时固有的可降解性或屏障完整性破坏。该发明还提供了一种具有联合治疗和诊断功能的脂质体，通过共包埋离子耦合的诊断和治疗剂，其中一种实施方式是使用阴离子螯合剂的方法，为脂质体内已包埋成像剂的脂质体加载两性治疗碱。该发明通过将脂质体脂质层插入脂质聚合物锚定的远程感测报告分子来成像治疗脂质体。该发明允许集成递送系统成像疾病组织中的分子指纹，治疗和治疗监测。
• Liposomes useful for drug delivery
  申请人：Hong Keelung

  公开号：US20070116753A1

  公开（公告）日：2007-05-24

  The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.

  本发明提供了含有取代铵和/或多阴离子的脂质体组合物，可选地含有所需的治疗或成像实体。本发明还提供了制备本发明所提供的脂质体组合物的方法。
• Macromolecular Gsh-Activiated Glyoxylase I Inhibitors
  申请人：Creighton Donald

  公开号：US20070287672A1

  公开（公告）日：2007-12-13

  This invention relates to macromolecular prodrugs having antitumor activity when activated by GSH, and methods for synthesizing and administering these to patients. More particularly, this invention relates to, inter alia, the synthesis and use of polyacrylamide carriers to target anticancer prodrugs to tumors, and to release active antitumor agents selectively in tumor cells. These active antitumor agents target the active site of the methylglyoxal-detoxifying enzyme glyoxalase I to thereby cause tumor regression.

  本发明涉及通过GSH激活具有抗肿瘤活性的高分子前药，以及合成和给患者施用这些前药的方法。更具体地说，本发明涉及使用聚丙烯酰胺载体以将抗癌前药定向到肿瘤，并在肿瘤细胞中选择性地释放活性抗肿瘤剂的合成和使用。这些活性抗肿瘤剂靶向甲基乙二醛解毒酶甘氧醛酸酶I的活性位点，从而导致肿瘤退化。
• Liposomes Useful for Drug Delivery
  申请人：Hong Keelung

  公开号：US20120171283A1

  公开（公告）日：2012-07-05

  The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provides methods of making the liposome compositions provided by the present invention.

  本发明提供了含有取代铵和/或多阴离子的脂质体组合物，可选择性地含有所需的治疗或成像实体。本发明还提供了制备本发明所提供的脂质体组合物的方法。
• LIPOSOMES USEFUL FOR DRUG DELIVERY
  申请人：Merrimack Pharmaceuticals, Inc.

  公开号：US20140154298A1

  公开（公告）日：2014-06-05

  The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provides methods of making the liposome compositions provided by the present invention.

  本发明提供了含有取代铵和/或多阴离子的脂质体组合物，并且可以选择性地含有所需的治疗或成像实体。本发明还提供了制备本发明提供的脂质体组合物的方法。