Juliflorine

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 英文名称: Juliflorine
• 英文别名: (2S,3S,6R)-6-[10-[6-[10-[(2R,5S,6S)-5-hydroxy-6-methylpiperidin-2-yl]decyl]-1,2,3,5,8,8a-hexahydroindolizin-8-yl]decyl]-2-methylpiperidin-3-ol
• 化学式: C₄₀H₇₅N₃O₂
• 分子量: 630.0
• InChiKey: JOTBJXJGDRSICD-TWELVPRFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.4
• 重原子数：
  45
• 可旋转键数：
  22
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  67.8
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• [EN] PYRIDINIUM SALTS AND USES THEREOF<br/>[FR] SELS DE PYRIDINIUM ET LEURS UTILISATIONS
  申请人：UNIV LONDON

  公开号：WO2018189199A1

  公开（公告）日：2018-10-18

  A 1,3,5-trisubstituted pyridinium salt of general formula I (I) wherein Xn- is a counterion in which n is an integer from 1 to 4; wherein R2 and R3 are each independently a substituent group comprising Ar, wherein Ar is an aryl or heteroaryl group, which is substituted or unsubstituted; wherein R1 is a substituent group linked to the quarternary nitrogen of the pyridinium ring by an aliphatic carbon; and wherein, when R1 is benzyl, R2 and R3 are not both phenyl, 3-MeO phenyl, 4-Br phenyl, 3-CF3 phenyl, 2-Me phenyl or 4-(4-tert BuPh) phenyl; when R1 is 3-MeO phenethyl, R2 and R3 are not both 3-MeO phenyl; and when R1 is dimethoxyphenethyl, R2 and R3 are not both phenyl.

  通式I（I）的1,3,5-三取代吡啶盐，其中Xn-是一个计数离子，其中n是从1到4的整数；其中R2和R3分别是包含Ar的取代基团，其中Ar是取代或未取代的芳基或杂环基团；其中R1是通过脂肪碳与吡啶环的季铵氮连接的取代基团；当R1是苄基时，R2和R3不都是苯基、3-甲氧基苯基、4-溴苯基、3-三氟甲基苯基、2-甲基苯基或4-(4-叔丁基苄基)苯基；当R1是3-甲氧基苄基时，R2和R3不都是3-甲氧基苯基；当R1是二甲氧基苄基时，R2和R3不都是苯基。
• Natural immunostimulant compositions, methods for obtaining the same and phamaceutical formulations thereof
  申请人：Mitra Kumar Shankar

  公开号：US20050238736A1

  公开（公告）日：2005-10-27

  A natural immunostimulant composition for the treatment of immunodeficiency, the composition comprising extract of plant Symplocos racemosa and/or plant Prosopis glandulosa and a pharmaceutically acceptable carrier is disclosed. Also disclosed are methods for obtaining the plant extract, methods for preparing the composition and methods of treating diseases related to immunodeficiency.

  一种用于治疗免疫缺陷症的天然免疫刺激剂组合物，该组合物由以下植物的提取物组成 葡萄 和/或植物 植物 和一种药学上可接受的载体。还公开了获得植物提取物的方法、制备组合物的方法以及治疗与免疫缺陷有关的疾病的方法。
• NATURAL IMMUNOSTIMULANT COMPOSITIONS, METHODS FOR OBTAINING THE SAME AND PHARMACEUTICAL FORMULATIONS THEREOF
  申请人：MITRA Shankar Kumar

  公开号：US20090136602A1

  公开（公告）日：2009-05-28

  A natural immunostimulant composition for the treatment of immunodeficiency, the composition comprising extract of plant Symplocos racemosa and/or plant Prosopis glandulosa and a pharmaceutically acceptable carrier is disclosed. Also disclosed are methods for obtaining the plant extract, methods for preparing the composition and methods of treating diseases related to immunodeficiency.
• US7507424B2
  申请人：——

  公开号：US7507424B2

  公开（公告）日：2009-03-24
• US7943181B2
  申请人：——

  公开号：US7943181B2

  公开（公告）日：2011-05-17