(-)-(2S,4S)-1-[2-(Hydroxymethyl)-1,3-dioxolan-4-yl]-5-methylcytosine

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: (-)-(2S,4S)-1-[2-(Hydroxymethyl)-1,3-dioxolan-4-yl]-5-methylcytosine
• 英文别名: 4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-methylpyrimidin-2-one
• 化学式: C₉H₁₃N₃O₄
• 分子量: 227.22
• InChiKey: MJGOECXTQVPSJN-BQBZGAKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  97.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Method for the treatment or prevention of Flaviviridea viral infection using nucleoside analogues
  申请人：BioChem Pharma Inc.

  公开号：US20030225037A1

  公开（公告）日：2003-12-04

  In accordance with the present invention there is provided a method for treating or preventing a Flaviviridea viral infection in a host comprising administering a therapeutically effective amount of at least one compound of formula (I) or (II) 1 or or a pharmaceutically acceptable salts thereof, wherein Ra, R, Z and Y are defined in the application.

  根据本发明，提供了一种用于治疗或预防宿主中的Flavivirideaviral感染的方法，包括给予至少一种式(I)或(II)1或它们的药学上可接受的盐的治疗有效量，其中Ra、R、Z和Y在申请中有定义。
• METHOD FOR THE TREATMENT OR PREVENTION OF i FLAVIVIRIDAE /i VIRAL INFECTION USING NUCLEOSIDE ANALOGUES
  申请人：BIOCHEM PHARMA INC

  公开号：EP1225899A2

  公开（公告）日：2002-07-31
• US6566365B1
  申请人：——

  公开号：US6566365B1

  公开（公告）日：2003-05-20
• [EN] METHOD FOR THE TREATMENT OR PREVENTION OF FLAVIVIRIDAE VIRAL INFECTION USING NUCLEOSIDE ANALOGUES<br/>[FR] PROCEDE DE TRAITEMENT OU DE PREVENTION DE L'INFECTION VIRALE PAR FLAVIVIRIDAE FAISANT APPEL A DES ANALOGUES DES NUCLEOSIDES
  申请人：IAF BIOCHEM INT

  公开号：WO2001032153A2

  公开（公告）日：2001-05-10

  In accordance with the present invention there is provided a method for treating or preventing a Flaviviridae viral infection in a host comprising administering a therapeutically effective amount of at least one compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof, wherein Ra, R, Z and Y are defined in the application.