1-[4-(4-Propoxyphenyl)sulfanylbut-2-ynyl]piperidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-[4-(4-Propoxyphenyl)sulfanylbut-2-ynyl]piperidine
• 化学式: C₁₈H₂₅NOS
• 分子量: 303.469
• InChiKey: WKCDFHWSROEIIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  37.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  p-Propoxythiophenol 在 氢氧化钾 、 copper(l) chloride 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 4.0h， 生成 1-[4-(4-Propoxyphenyl)sulfanylbut-2-ynyl]piperidine
  参考文献：
  名称：

  Synthesis and antifungal activity of some alkynylthio compounds

  摘要：

  Some 4-(p-alkoxyphenylthio)but-2-yn-yl-amine hydrochlorides and 4-(p-alkoxyphenylthio)prop-1-yn-yl-iodides were prepared and tested for their antifungal activity. All the tested compounds were active in inhibiting the growth of 4 fungal types. The iodine compounds were the more effective.

  DOI：

  10.1016/0223-5234(92)90118-k

文献信息

• Synthesis and antifungal activity of some alkynylthio compounds
  作者：SS Papakonstantinou-Garoufalia、AE Papadaki-Valiraki、A Chytiroglou-Lada

  DOI：10.1016/0223-5234(92)90118-k

  日期：1992.11

  Some 4-(p-alkoxyphenylthio)but-2-yn-yl-amine hydrochlorides and 4-(p-alkoxyphenylthio)prop-1-yn-yl-iodides were prepared and tested for their antifungal activity. All the tested compounds were active in inhibiting the growth of 4 fungal types. The iodine compounds were the more effective.