7-chloro-1-methyl-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 7-chloro-1-methyl-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepin-2-one
• 化学式: C₁₄H₁₂ClN₃O
• 分子量: 273.72
• InChiKey: AWJJERBMJMDPDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  48.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Compositions and methods for the treatment of aberrant angiogenesis
  申请人：The Schepens Eye Research Institute, Inc.

  公开号：US11229662B2

  公开（公告）日：2022-01-25

  The present subject matter provides compositions, formulations, and methods for inhibiting, treating, or preventing aberrant angiogenesis in a subject.

  本主题提供了用于抑制、治疗或预防受试者异常血管生成的组合物、制剂和方法。
• METHODS FOR TREATING LEUKEMIA AND DISORDERS MEDIATED BY CBF AND RUNX1 PROTEINS
  申请人：The U.S.A. as represented by the Secretary, Department of Health and Human Services

  公开号：EP2685985A1

  公开（公告）日：2014-01-22
• COMPOSITIONS AND METHODS FOR THE TREATMENT OF ABERRANT ANGIOGENESIS
  申请人：The Schepens Eye Research Institute, Inc.

  公开号：US20190350961A1

  公开（公告）日：2019-11-21

  The present subject matter provides compositions, formulations, and methods for inhibiting, treating, or preventing aberrant angiogenesis in a subject.
• NANO-EMULSION OF CBFß-RUNX1 INHIBITOR FOR OCULAR DRUG DELIVERY
  申请人：The Schepens Eye Research Institute, Inc.

  公开号：US20200375899A1

  公开（公告）日：2020-12-03

  The invention provides ocular formulations and features a nano-emulsion composition, e.g., a nano-emulsion comprising a CBFβ-RUNX1 inhibitor. The composition comprises a particle with a length of less than 200 nanometers in at least one dimension.
• RUNX1 INHIBITION FOR TREATMENT OF PROLIFERATIVE VITREORETINOPATHY AND CONDITIONS ASSOCIATED WITH EPITHELIAL TO MESENCHYMAL TRANSITION
  申请人：The Schepens Eye Research Institute, Inc.

  公开号：US20200377888A1

  公开（公告）日：2020-12-03

  The present subject matter provides compositions, formulations and methods for preventing or reducing proliferation or migration of retinal cells or epithelial to mesenchymal transition in ocular cells or cells from other tissues.