[[(2S,5R)-5-(4-amino-5-fluoro-2-oxo-pyrimidin-1-yl)-1,3-oxathiolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: [[(2S,5R)-5-(4-amino-5-fluoro-2-oxo-pyrimidin-1-yl)-1,3-oxathiolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate
• 英文别名: [[(2S,5R)-5-(4-amino-5-fluoro-2-oxopyrimidin-1-yl)-1,3-oxathiolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• 化学式: C₈H₁₃FN₃O₁₂P₃S
• 分子量: 487.19
• InChiKey: WIEOLFZNMKSGEX-RITPCOANSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  253
• 氢给体数：
  5
• 氢受体数：
  14

文献信息

• [EN] PYRIMIDINE NUCLEOTIDES AND THEIR MONOPHOSPHATE PRODRUGS FOR TREATMENT OF VIRAL INFECTIONS AND CANCER<br/>[FR] NUCLÉOTIDES PYRIMIDINES ET LEURS PROMÉDICAMENTS MONOPHOSPHATES POUR LE TRAITEMENT D'INFECTIONS VIRALES ET DU CANCER
  申请人：RFS PHARMA LLC

  公开号：WO2014070771A1

  公开（公告）日：2014-05-08

  The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, cytomegalovirus (CMV), herpes viruses (HSV-1, HSV-2), Dengue virus, Yellow fever, or HBV in human patients or other animal hosts. The compounds are certain A^-hydroxycytidine nucleosides derivatives, modified monophosphate and phosphonates prodrugs analogs, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1, HIV-2, HCV, Norovirus, Saporovirus, cytomegalovirus (CMV), herpes viruses (HSV-1, HSV-2), Dengue virus, Yellow fever, and HBV.

  本发明涉及化合物、组合物和用于治疗或预防癌症和病毒感染的方法，特别是针对人类患者或其他动物宿主中的HIV、HCV、诺罗病毒、萨波罗病毒、巨细胞病毒（CMV）、疱疹病毒（HSV-1、HSV-2）、登革病毒、黄热病或HBV。这些化合物是某些A^-羟基胞苷核苷衍生物、改性的单磷酸盐和膦酸酯前药类似物，以及其药学上可接受的盐、前药和其他衍生物。特别地，这些化合物显示出对HIV-1、HIV-2、HCV、诺罗病毒、萨波罗病毒、巨细胞病毒（CMV）、疱疹病毒（HSV-1、HSV-2）、登革病毒、黄热病和HBV的强效抗病毒活性。
• MONOPHOSPHATE PRODRUGS OF DAPD AND ANALOGS THEREOF
  申请人：Schinazi Raymond F.

  公开号：US20120142627A1

  公开（公告）日：2012-06-07

  The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV and HBV, in human patients or other animal hosts. The compounds are certain 6-substituted-2-amino-purine dioxolane monophosphates or phosphonates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof.

  本发明涉及用于治疗或预防癌症和病毒感染，特别是HIV和HBV，在人类患者或其他动物宿主中的化合物、组合物和方法。这些化合物是某些6-取代-2-氨基嘧啶二氧杂环己糖单磷酸盐或膦酸盐，以及其药用可接受的盐、前药和其他衍生物。
• [EN] 2' -DISUBSTITUTED NUCLEOSIDE ANALOGS FOR TREATMENT OF THE FLAVIVIRIDAE FAMILY OF VIRUSES AND CANCER<br/>[FR] ANALOGUES DE NUCLÉOSIDES DISUBSTITUÉS EN 2' POUR LE TRAITEMENT DES VIRUS DE LA FAMILLE DES FLAVIVIRIDAE ET DU CANCER
  申请人：COCRYSTAL PHARMA INC

  公开号：WO2015164812A1

  公开（公告）日：2015-10-29

  The present invention is directed to compounds, compositions and methods for treating or preventing Flaviviridae family of viruses (including HCV, Yellow fever, Dengue, Chikungunya and West Nile virus), RSV and influenza infection and cancer in human subjects or other animal hosts. The compounds are as also pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof as pharmaceutical compositions and methods for treatment or prevention of HCV infection.

  本发明涉及化合物、组合物和方法，用于治疗或预防人类或其他动物宿主中的黄病毒科病毒（包括丙型肝炎病毒、黄热病、登革热、基孔肯雅热和西尼罗河病毒）、RSV和流感感染以及癌症。这些化合物也可以作为药物组成物的药理学上可接受的盐、前药和其他衍生物，用于治疗或预防丙型肝炎病毒感染的方法。
• AZIDO PURINE NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS
  申请人：Schinazi Raymond F.

  公开号：US20100279969A1

  公开（公告）日：2010-11-04

  The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HIV, HBV, and HCV, in human patients or other animal hosts. The compounds are 3′-azido-2′,3′-dideoxy purine nucleosides or phosphonates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1 resistance mutants including HIV-1 K65R , HTV-1 K70E , HIV-1 L74V , HIV-1 M184V , HIV-1 Q151M and inhibitory activity against HIV-1 RT harboring TAMS or insertion mutations including HIV-1 AZT3 , HIV-1 AZT7 , HIV-1 AZT9 , HIV-1 Q151M , or HIV-1 69insertion . In one embodiment, the compounds are 3′-azido-ddA, 3′-azido-ddG, or combinations thereof, administered with one or more additional antiviral agents that select for TAM mutations and/or the M 184V mutation, along with a pharmaceutically acceptable carrier.

  本发明涉及化合物、组合物和方法，用于治疗或预防病毒感染，特别是HIV、HBV和HCV，在人类患者或其他动物宿主中。这些化合物是3'-氮杂-2'，3'-二脱氧嘌呤核苷或膦酸盐，以及其它药物可接受的盐、前药和衍生物。特别地，这些化合物对HIV-1耐药突变体，包括HIV-1K65R、HTV-1K70E、HIV-1L74V、HIV-1M184V、HIV-1Q151M显示出强效的抗病毒活性，并且具有抑制HIV-1 RT携带TAMS或插入突变的活性，包括HIV-1AZT3、HIV-1AZT7、HIV-1AZT9、HIV-1Q151M或HIV-169插入。在一种实施方式中，这些化合物是3'-氮杂-ddA、3'-氮杂-ddG或其组合物，与一个或多个选择TAM突变和/或M 184V突变的其它抗病毒药物一起，以及药物可接受的载体一起给予。
• PURINE NUCLEOSIDE MONOPHOSPHATE PRODRUGS FOR TREATMENT OF CANCER AND VIRAL INFECTIONS
  申请人：Cho Jong Hyun

  公开号：US20120040924A1

  公开（公告）日：2012-02-16

  The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, HSV-1, HSV-2, Dengue virus, Yellow fever, and HBV in human patients or other animal hosts. The compounds are certain 6-substituted purine monophosphates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1, HIV-2, HCV, Norovirus, Saporovirus, HSV-1, HSV-2, Dengue virus, Yellow fever, and HBV.

  本发明涉及化合物、组合物和方法，用于治疗或预防癌症和病毒感染，特别是在人类患者或其他动物宿主中的HIV、HCV、Norovirus、Saporovirus、HSV-1、HSV-2、登革热病毒、黄热病和HBV。这些化合物是某些6-取代嘌呤单磷酸盐，以及其药学上可接受的盐、前药和其他衍生物。特别是这些化合物显示出对HIV-1、HIV-2、HCV、Norovirus、Saporovirus、HSV-1、HSV-2、登革热病毒、黄热病和HBV的强效抗病毒活性。