2-amino-9-[[1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1H-purin-6-one

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: 2-amino-9-[[1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1H-purin-6-one
• 化学式: C₁₁H₁₅N₅O₃
• 分子量: 265.27
• InChiKey: JLYSZBQNRJVPEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• [EN] METHOD FOR PREPARING CYCLOPROPANE DERIVATIVES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE CYCLOPROPANE
  申请人：OKAPI SCIENCES NV

  公开号：WO2013068042A1

  公开（公告）日：2013-05-16

  The present invention relates to the preparation of cyclopropane derivatives, in particular 2- amino-9-[[(1S,2R)-1,2- bis(hydroxymethyl) cyclopropyl] methyl]-4,8-dihydro-1H-purin-6-one, especially via the [(1S,7R)-4-phenyl-3,5-dioxabicyclo[5.1.0]octan-1-yl]methanol intermediate.

  本发明涉及环丙烷衍生物的制备，特别是2-氨基-9-[[（1S,2R）-1,2-双（羟甲基）环丙基]甲基]-4,8-二氢-1H-嘌呤-6-酮，特别是通过[(1S,7R)-4-苯基-3,5-二氧杂环[5.1.0]辛-1-基]甲醇中间体。
• METHOD FOR PREPARING CYCLOPROPANE DERIVATIVES
  申请人：Kiss Eleonora

  公开号：US20150051394A1

  公开（公告）日：2015-02-19

  The present invention relates to the preparation of cyclopropane derivatives, in particular 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-4,8-dihydro-1H-purin-6-one, especially via the [(1S,7R)-4-phenyl-3,5-dioxabicyclo[5.1.0]octan-1-yl]methanol intermediate.

  本发明涉及环丙烷衍生物的制备，特别是2-氨基-9-[[（1S,2R）-1,2-双（羟甲基）环丙基]甲基]-4,8-二氢-1H-嘌呤-6-酮，尤其是通过[(1S,7R)-4-苯基-3,5-二氧杂环[5.1.0]辛-1-基]甲醇中间体。
• METHOD OF TREATING VIRAL INFECTIONS
  申请人：EPIPHANY BIOSCIENCES

  公开号：US20150050241A1

  公开（公告）日：2015-02-19

  The present invention is directed to methods and compositions employing 9-(4-hydroxy-2-(hydroxymethyl)butyl)guanine (“H2G”) or derivatives or analogs thereof for the treatment of viral diseases, as well as for the treatment of other conditions, including, but not limited to, cancer, chronic fatigue syndrome, Alzheimer's disease, multiple sclerosis and Graves' disease. The H2G or derivative or analog thereof can be administered in a pharmaceutical composition and can be administered with an additional antiviral therapeutic agent or another agent for the treatment of other conditions.

  本发明涉及使用9-（4-羟基-2-（羟甲基）丁基）鸟嘌呤（“H2G”）或其衍生物或类似物的方法和组合物，用于治疗病毒性疾病，以及用于治疗其他疾病，包括但不限于癌症、慢性疲劳综合征、阿尔茨海默病、多发性硬化症和格雷夫斯病。 H2G或其衍生物或类似物可以在药物组合物中给予，并且可以与其他抗病毒治疗药物或其他治疗其他疾病的药物一起给予。
• Synthesis of acyclic nucleoside derivatives
  申请人：Leanna Robert M.

  公开号：US20050250795A1

  公开（公告）日：2005-11-10

  Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of R 1 and R 2 is an amino acid acyl group and the other of R 1 and R 2 is a —C(O)C 3 -C 21 saturated or monounsaturated, optionally substituted alkyl and R 3 is OH or H; or a pharmaceutically acceptable salt thereof.

  制备无环核苷衍生物的方法和新型中间体，其化学式为：其中R1和R2中的一个是氨基酸酰基，另一个是饱和或单不饱和的（可选地取代的）C（O）C3-C21烷基，R3为OH或H；或其药学上可接受的盐。
• Microorganisms and cells for diagnosis and therapy of tumors
  申请人：Genelux Corporation

  公开号：EP1914316A2

  公开（公告）日：2008-04-23

  Described are diagnostic and pharmaceutical compositions comprising a microorganism or cell containing a DNA sequence encoding a detectable protein or a protein capable of inducing a detectable signal, e.g. a luminescent or fluorescent protein, and, in a particular embodiment, furthermore (a) DNA sequence(s) encoding (a) protein(s) suitable for tumor therapy and/or elimination of metastatic tumors, e.g. a cytotoxic or cytostatic protein.

  所述的诊断和药物组合物包含一种微生物或细胞，该微生物或细胞含有编码可检测蛋白质或能够诱导可检测信号的蛋白质（如发光或荧光蛋白质）的 DNA 序列，在一个特定的实施方案中，还包含编码适用于肿瘤治疗和/或消除转移性肿瘤的蛋白质（如细胞毒性或细胞抑制性蛋白质）的 DNA 序列。