2-oxo-N-[(1R)-1-phenylethyl]-4-(3-pyridylmethylsulfanyl)azetidine-1-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 2-oxo-N-[(1R)-1-phenylethyl]-4-(3-pyridylmethylsulfanyl)azetidine-1-carboxamide
• 英文别名: 2-oxo-N-[(1R)-1-phenylethyl]-4-(pyridin-3-ylmethylsulfanyl)azetidine-1-carboxamide
• 化学式: C₁₈H₁₉N₃O₂S
• 分子量: 341.434
• InChiKey: PDQOUDXGMUCGEB-FWJOYPJLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  87.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-吡啶甲醇 在 4-二甲氨基吡啶 、 sodium hydroxide 、 三乙胺 、 三苯基膦 、 palladium dichloride 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 生成 2-oxo-N-[(1R)-1-phenylethyl]-4-(3-pyridylmethylsulfanyl)azetidine-1-carboxamide
  参考文献：
  名称：

  Inhibition of human cytomegalovirus protease N o with monocyclic β-lactams

  摘要：

  Monocyclic beta-lactams have been identified as potent and selective inhibitors of the human cytomegalovirus protease (HCMV) N-o. Two series of these inhibitors are described, a peptidyl series of compounds and non-peptidic molecules featuring lower molecular weights. The SAR work that lead to the discovery of these inhibitors, together with their synthesis is also disclosed. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00240-6

文献信息

• Inhibition of human cytomegalovirus protease N o with monocyclic β-lactams
  作者：R. Déziel、E. Malenfant

  DOI：10.1016/s0960-894x(98)00240-6

  日期：1998.6

  Monocyclic beta-lactams have been identified as potent and selective inhibitors of the human cytomegalovirus protease (HCMV) N-o. Two series of these inhibitors are described, a peptidyl series of compounds and non-peptidic molecules featuring lower molecular weights. The SAR work that lead to the discovery of these inhibitors, together with their synthesis is also disclosed. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.