(α-N-propynoyl)-Lys-Gly-Phe-Gly-Lys | 894793-08-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (α-N-propynoyl)-Lys-Gly-Phe-Gly-Lys
• 英文别名: propioloyl-Lys-Gly-Phe-Gly-Lys-OH；(2S)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2S)-6-amino-2-(prop-2-ynoylamino)hexanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]hexanoic acid
• CAS: 894793-08-9
• 化学式: C₂₈H₄₁N₇O₇
• 分子量: 587.676
• InChiKey: KQNUMBDBEAXZEH-FKBYEOEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  42
• 可旋转键数：
  20
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  235
• 氢给体数：
  8
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2-[18F]fluoroethylazide 、 (α-N-propynoyl)-Lys-Gly-Phe-Gly-Lys 在 铜 作用下， 以 水 、 乙腈 为溶剂， 反应 0.08h， 以86%的产率得到(2S)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2S)-6-amino-2-[[1-(2-(18F)fluoranylethyl)triazole-4-carbonyl]amino]hexanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]hexanoic acid
  参考文献：
  名称：

  WO2006/67376

  摘要：

  公开号：

文献信息

• Radiolabelling Methods
  申请人：Arstad Erik

  公开号：US20090311177A1

  公开（公告）日：2009-12-17

  The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods and reagents labelling a vector such as a peptide comprising reaction of a compound of formula (I) with a compound of formula (II): R*-L2-N 3 (II) or, a compound of formula (III) with a compound of formula (IV) in the presence of a Cu (I) catalyst. The resultant labelled conjugates are useful as diagnostic agents, for example, as radiopharmaceuticals more specifically for use in Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) or for radiotherapy.
• CHEMICAL METHODS AND APPARATUS
  申请人：Arstad Erik

  公开号：US20100069609A1

  公开（公告）日：2010-03-18

  The invention relates to methods and apparatus for labelling a biologically active vector such as a peptide with reporter moiety such as a radionuclide. The methods comprise reaction of a compound of formula (I) with a compound of formula (II): R*-L2-N3 (II) or, a compound of formula (III) with a compound of formula (IV) wherein: L1, L2, L3, and L4 are each Linker groups; R* is a reporter moiety; in a narrow bore copper vessel. Microfluidic devices for performing the methods of the invention are also claimed.
• RADIOLABELLING METHODS
  申请人：ARSTAD ERIK

  公开号：US20110236311A1

  公开（公告）日：2011-09-29

  The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods and reagents labelling a vector such as a peptide comprising reaction of a compound of formula (I) with a compound of formula (II): or, a compound of formula (III) with a compound of formula (IV) in the presence of a Cu (I) catalyst. The resultant labelled conjugates are useful as diagnostic agents, for example, as radiopharmaceuticals more specifically for use in Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) or for radiotherapy.
• US7972588B2
  申请人：——

  公开号：US7972588B2

  公开（公告）日：2011-07-05
• US8679455B2
  申请人：——

  公开号：US8679455B2

  公开（公告）日：2014-03-25