Ac-(RANTES 53 62)-NH2

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: Ac-(RANTES 53 62)-NH2
• 英文别名: (4S)-4-[[(2S)-1-acetylpyrrolidine-2-carbonyl]amino]-5-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-oxopentanoic acid
• 化学式: C₆₆H₁₀₁N₁₇O₁₆
• 分子量: 1388.63
• InChiKey: KCKTZZFAVPWVRB-RGMKYYKLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.1
• 重原子数：
  99
• 可旋转键数：
  44
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  552
• 氢给体数：
  18
• 氢受体数：
  19

反应信息

• 作为产物：
  描述：

  Fmoc-L-脯氨酸 、 Fmoc-O-叔丁基-L-谷氨酸 、 乙酸酐 、 N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-L-赖氨酸 、 Fmoc-L-色氨酸(Boc)-OH 、 alkaline earth salt of/the/ methylsulfuric acid 生成 Ac-(RANTES 53 62)-NH2
  参考文献：
  名称：

  Anti-HIV-1 peptides derived from partial amino acid sequences of CC-Chemokine RANTES

  摘要：

  Fifteen acetyl-peptide-amides with partial amino acid sequences of RANTES (regulated upon activation, normal T-cell expressed and secreted), all Cys residues of which were substituted by Ala, were synthesized, and screened for anti-HIV-1 activity. Peptides corresponding to 1-10. 37-46. and 57-68 showed marked activity against CC-chemokine receptor 5-using HIV-1(JR-CSF) (% inhibition at 100 nM 69, 82 76%, respectively). The results indicate that multiple regions, including the N-terminal part responsible for chemotactic activity. are involved in anti-HIV-1 activity of RANTES, yielding possible lead compounds for anti-HIV-1 agents. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00271-7

文献信息

• Anti-HIV-1 peptides derived from partial amino acid sequences of CC-Chemokine RANTES
  作者：Yasuhiro Nishiyama、Tsutomu Murakami、Suguru Shikama、Keisuke Kurita、Naoki Yamamoto

  DOI：10.1016/s0968-0896(02)00271-7

  日期：2002.12

  Fifteen acetyl-peptide-amides with partial amino acid sequences of RANTES (regulated upon activation, normal T-cell expressed and secreted), all Cys residues of which were substituted by Ala, were synthesized, and screened for anti-HIV-1 activity. Peptides corresponding to 1-10. 37-46. and 57-68 showed marked activity against CC-chemokine receptor 5-using HIV-1(JR-CSF) (% inhibition at 100 nM 69, 82 76%, respectively). The results indicate that multiple regions, including the N-terminal part responsible for chemotactic activity. are involved in anti-HIV-1 activity of RANTES, yielding possible lead compounds for anti-HIV-1 agents. (C) 2002 Elsevier Science Ltd. All rights reserved.