N-(Benzoyl)-2-methyl-N'-[(4-fluoro-indol-3-yl)-oxoacetyl]-piperazine | 313335-42-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(Benzoyl)-2-methyl-N'-[(4-fluoro-indol-3-yl)-oxoacetyl]-piperazine
• 英文别名: Piperazine, 1-benzoyl-4-[2-(4-fluoro-1H-indol-3-yl)-1,2-dioxoethyl]-2-methyl-；1-(4-benzoyl-3-methylpiperazin-1-yl)-2-(4-fluoro-1H-indol-3-yl)ethane-1,2-dione
• CAS: 313335-42-1
• 化学式: C₂₂H₂₀FN₃O₃
• 分子量: 393.418
• InChiKey: PNJPCIYMKXINDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  73.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• EP1105135A4
  申请人：——

  公开号：EP1105135A4

  公开（公告）日：2001-12-12
• ANTIVIRAL INDOLEOXOACETYL PIPERAZINE DERIVATIVES
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP1105135A1

  公开（公告）日：2001-06-13
• US6469006B1
  申请人：——

  公开号：US6469006B1

  公开（公告）日：2002-10-22
• [EN] ANTIVIRAL INDOLEOXOACETYL PIPERAZINE DERIVATIVES<br/>[FR] DERIVES D'INDOLEOXOACETYLPIPERAZINE, A PROPRIETES ANTIVIRALES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2000076521A1

  公开（公告）日：2000-12-21

  This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with indoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.