1-(4-Benzoyl-piperazin-1-yl)-2-[7-(5-chloromethyl-1H-[1,2,4]triazol-3-yl)-4-fluoro-1H-indol-3-yl]-ethane-1,2-dione | 389630-73-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(4-Benzoyl-piperazin-1-yl)-2-[7-(5-chloromethyl-1H-[1,2,4]triazol-3-yl)-4-fluoro-1H-indol-3-yl]-ethane-1,2-dione
• 英文别名: 1-(4-benzoylpiperazin-1-yl)-2-[7-[3-(chloromethyl)-1H-1,2,4-triazol-5-yl]-4-fluoro-1H-indol-3-yl]ethane-1,2-dione；1-(4-benzoylpiperazin-1-yl)-2-[7-[5-(chloromethyl)-1H-1,2,4-triazol-3-yl]-4-fluoro-1H-indol-3-yl]ethane-1,2-dione
• CAS: 389630-73-3
• 化学式: C₂₄H₂₀ClFN₆O₃
• 分子量: 494.913
• InChiKey: RTSHUVNBIXOQSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives
  申请人：——

  公开号：US20030069245A1

  公开（公告）日：2003-04-10

  This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with indoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

  这项发明提供了具有药物和生物影响性质的化合物，它们的药物组合物和使用方法。具体而言，该发明涉及吲哚酮乙酰哌嗪衍生物。这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药物、抗感染药物、免疫调节剂或HIV进入抑制剂结合使用。更具体地，本发明涉及HIV和艾滋病的治疗。
• COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED INDOLEOXOACETIC PIPERAZINE DERIVATIVES
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP1299382A1

  公开（公告）日：2003-04-09
• EP1299382A4
  申请人：——

  公开号：EP1299382A4

  公开（公告）日：2004-02-11
• US6573262B2
  申请人：——

  公开号：US6573262B2

  公开（公告）日：2003-06-03
• [EN] COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED INDOLEOXOACETIC PIPERAZINE DERIVATIVES<br/>[FR] COMPOSITION ET ACTIVITE ANTIVIRALE DE DERIVES DE PIPERAZINE INDOLEOXOACETIQUE SUBSTITUES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2002004440A1

  公开（公告）日：2002-01-17

  This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and mthod of use. In particular, the invention is converned with indoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. Mor particularly, the present invention relates to the treatment of HIV and AIDS.