methyl (2S)-2-[[4-[[(1S)-1-benzyl-2-methoxy-2-oxo-ethyl]carbamoyl]-1H-imidazole-5-carbonyl]amino]-3-phenyl-propanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2S)-2-[[4-[[(1S)-1-benzyl-2-methoxy-2-oxo-ethyl]carbamoyl]-1H-imidazole-5-carbonyl]amino]-3-phenyl-propanoate
• 英文别名: methyl (2S)-2-[[4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]carbamoyl]-1H-imidazole-5-carbonyl]amino]-3-phenylpropanoate
• 化学式: C₂₅H₂₆N₄O₆
• 分子量: 478.505
• InChiKey: FYIDASHAZBANMO-OALUTQOASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  35
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  140
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4H,9H-diimidazo<1,5-a; 1',5'-d>pyrazine-5,10-dione-1,6-dicarboxylic dichloride 、 L-苯丙氨酸甲酯盐酸盐 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以94%的产率得到methyl (2S)-2-[[4-[[(1S)-1-benzyl-2-methoxy-2-oxo-ethyl]carbamoyl]-1H-imidazole-5-carbonyl]amino]-3-phenyl-propanoate
  参考文献：
  名称：

  Synthesis of Symmetric Bis(imidazole-4,5-dicarboxamides) Substituted with Amino Acids

  摘要：

  A series of symmetric bis(imidazole-4,5-dicarboxamides) (bis-I45DCs) were prepared with amino acid esters and a variety of linker groups. The critical pyrazine intermediates, substituted with amino acid esters, were synthesized by stoichiometric control of the amino acid ester, even though primary alkanamines, in comparison, generally offer less selectivity for this reaction. Diamines are added to subsequently react with and open the remaining acyl imidazole bonds in the pyrazine intermediates and thereby yield the bis-I45DCs.

  DOI：

  10.1021/jo049045z

文献信息

• Synthesis of Symmetric Bis(imidazole-4,5-dicarboxamides) Substituted with Amino Acids
  作者：Alexander V. Wiznycia、Jeremy R. Rush、Paul W. Baures

  DOI：10.1021/jo049045z

  日期：2004.11.1

  A series of symmetric bis(imidazole-4,5-dicarboxamides) (bis-I45DCs) were prepared with amino acid esters and a variety of linker groups. The critical pyrazine intermediates, substituted with amino acid esters, were synthesized by stoichiometric control of the amino acid ester, even though primary alkanamines, in comparison, generally offer less selectivity for this reaction. Diamines are added to subsequently react with and open the remaining acyl imidazole bonds in the pyrazine intermediates and thereby yield the bis-I45DCs.