3-(4,6-Dimethylpyridin-2-yl)-2-(2-fluoro-6-methoxyphenyl)-1,3-thiazolidin-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(4,6-Dimethylpyridin-2-yl)-2-(2-fluoro-6-methoxyphenyl)-1,3-thiazolidin-4-one
• 化学式: C₁₇H₁₇FN₂O₂S
• 分子量: 332.399
• InChiKey: WARRVPIVVUTEQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  67.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氨基-4,6-二甲基吡啶 、 巯基乙酸 、 2-氟-6-甲氧基苯甲醛 以 甲苯 为溶剂， 反应 48.0h， 以33%的产率得到3-(4,6-Dimethylpyridin-2-yl)-2-(2-fluoro-6-methoxyphenyl)-1,3-thiazolidin-4-one
  参考文献：
  名称：

  Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents

  摘要：

  Several 2,3-diaryl-1,3-thiazolidin-4-ones were synthesized and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30-50 nM concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs).

  DOI：

  10.1016/j.farmac.2003.09.001

文献信息

• Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents
  作者：Angela Rao、Jan Balzarini、Anna Carbone、Alba Chimirri、Erik De Clercq、Anna Maria Monforte、Pietro Monforte、Christophe Pannecouque、Maria Zappalà

  DOI：10.1016/j.farmac.2003.09.001

  日期：2004.1

  Several 2,3-diaryl-1,3-thiazolidin-4-ones were synthesized and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30-50 nM concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs).