1-O'-tert-butyl 1-O,1-O',3-O-triethyl 5'-chloro-2'-oxospiro[cyclopent-3-ene-2,3'-indole]-1,1,1',3-tetracarboxylate | 1269701-43-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-O'-tert-butyl 1-O,1-O',3-O-triethyl 5'-chloro-2'-oxospiro[cyclopent-3-ene-2,3'-indole]-1,1,1',3-tetracarboxylate
• CAS: 1269701-43-0
• 化学式: C₂₆H₃₀ClNO₉
• 分子量: 535.979
• InChiKey: ONNHKUIQWHHJRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  37
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  126
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  在 4-二甲氨基吡啶 、 三丁基膦 作用下， 以 乙二醇乙醚 、 甲苯 为溶剂， 反应 3.0h， 生成 1-O'-tert-butyl 1-O,1-O',3-O-triethyl 5'-chloro-2'-oxospiro[cyclopent-3-ene-2,3'-indole]-1,1,1',3-tetracarboxylate
  参考文献：
  名称：

  Phosphine- and Nitrogen-Containing Lewis Base Catalyzed Highly Regioselective and Geometric Selective Cyclization of Isatin Derived Electron-Deficient Alkenes with Ethyl 2,3-Butadienoate

  摘要：

  An interesting phosphine-containing Lewis base catalyzed highly regioselective [3 + 2] cycloaddition and a novel nitrogen-containing Lewis base catalyzed highly geometric selective [4 + 2] cycloaddition of isatin derived alpha,beta-unsaturated diesters with alpha-allenic ester have been disclosed to give the corresponding cyclic products in good to excellent yields under mild conditions. A plausible reaction mechanism has also been proposed on the basis of previous literature and our own investigation.

  DOI：

  10.1021/ol1031798

文献信息

• Phosphine- and Nitrogen-Containing Lewis Base Catalyzed Highly Regioselective and Geometric Selective Cyclization of Isatin Derived Electron-Deficient Alkenes with Ethyl 2,3-Butadienoate
  作者：Xiu-Chun Zhang、Shu-Hua Cao、Yin Wei、Min Shi

  DOI：10.1021/ol1031798

  日期：2011.3.4

  An interesting phosphine-containing Lewis base catalyzed highly regioselective [3 + 2] cycloaddition and a novel nitrogen-containing Lewis base catalyzed highly geometric selective [4 + 2] cycloaddition of isatin derived alpha,beta-unsaturated diesters with alpha-allenic ester have been disclosed to give the corresponding cyclic products in good to excellent yields under mild conditions. A plausible reaction mechanism has also been proposed on the basis of previous literature and our own investigation.